212555-23-2

Basic information

• Product Name: (2,4,6-trimethoxyphenyl)methanethiol
• Synonyms: (2,4,6-trimethoxyphenyl)methanethiol;2,4,6-Trimethoxybenzylmercaptan
• CAS NO: 212555-23-2
• Molecular Formula: C₁₀H₁₄O₃S
• Molecular Weight: 214.284
• Mol File: 212555-23-2.mol

Chemical Properties

• Boiling Point: 326℃
• Flash Point: 151℃
• Appearance: /
• Density: 1.117
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.528
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 9.07±0.10(Predicted)
• CAS DataBase Reference: (2,4,6-trimethoxyphenyl)methanethiol(CAS DataBase Reference)
• NIST Chemistry Reference: (2,4,6-trimethoxyphenyl)methanethiol(212555-23-2)
• EPA Substance Registry System: (2,4,6-trimethoxyphenyl)methanethiol(212555-23-2)

Safety Data

• Hazardous Substances Data: 212555-23-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
(2,4,6-Trimethoxyphenyl)methanethiol is used as a reactant for the synthesis of thiolactone polymers that mimic natural nucleosides. These synthetic nucleosides have potential applications in the development of new drugs, particularly in the treatment of viral infections and cancer, due to their ability to interfere with the replication and transcription processes of pathogens.
Used in Polymer Synthesis:
In the field of polymer chemistry, (2,4,6-Trimethoxyphenyl)methanethiol serves as a key reactant in the creation of thiolactone polymers. These polymers exhibit unique properties, such as enhanced stability and reactivity, which can be exploited in various industrial applications, including the development of advanced materials with tailored properties for use in electronics, coatings, and adhesives.
Used in Chemical Research:
(2,4,6-Trimethoxyphenyl)methanethiol is also utilized as a research compound in academic and industrial laboratories. Its unique structure and reactivity make it an interesting subject for studying various chemical reactions and mechanisms, contributing to the advancement of knowledge in organic chemistry and related fields.

InChI:InChI=1/C10H14O3S/c1-11-7-4-9(12-2)8(6-14)10(5-7)13-3/h4-5,14H,6H2,1-3H3

Upstream product

• 61040-78-6 2,4,6-trimethoxybenzyl alcohol 
• 830-79-5 2,4,6-trimethoxybenzaldehyde 
• 1197342-89-4 Boc-L-Ala-STmob 

Downstream Products

• 881913-37-7 3-tert-butoxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)-thiobutyric acid 2,4,6-trimethoxy-benzyl ester 
• 946524-10-3 Alloc-D,L-Ncy(Tmob)-OH 
• 366808-14-2 (Z)-2-hydroxystyryl-2,4,6-trimethoxybenzylsulfide 
• 366808-12-0 (Z)-2-hydroxystyryl-2,4,6-trimethoxybenzylsulfone 
• 1158245-54-5 Boc-L-Phe-STmob 
• 1158245-51-2 Fmoc-L-Ala-STmob 
• 1154041-20-9 S,S'-bis(2,4,6-trimethoxybenzyl) N-benzyloxycarbonyl-L-dithioaspartate 
• 1174889-96-3 S-2,4,6-trimethoxybenzyl N-Fluoren-9-ylmethoxycarbonyl-L-thiophenylalaninate 
• 1227069-44-4 S-2,4,6-trimethoxybenzyl 3,5-bis(prop-2-ynyloxy)benzothioate 
• 1227069-45-5 S-2,4,6-trimethoxybenzyl 3,5-bis(2-(3,5-bis(prop-2-ynyloxy)benzamido)ethoxy)benzothioate 
• 1207193-10-9 S-2,4,6-trimethoxybenzyl 3-(prop-2-ynyloxy)benzothioate 
• 1234549-10-0 S,S'-bis(2,4,6-trimethoxybenzyl) N-tert-butoxycarbonyl-L-dithioaspartate 
• 1197342-90-7 NH₂-L-Ala-STmob 
• 1292784-04-3 S-2,4,6-trimethoxybenzyl 3,5-bis((4,8,24-trioxo-6,13,16,19-tetraoxa-3,9,23-triazaoctacos-27-yn-1-yl)oxy)benzothioate 

Relevant articles and documents

Dynamic and Responsive DNA-like Polymers

The synthesis of thiolactone monomers that mimic natural nucleosides and engage in robust ring opening polymerizations (ROP) is herein described. As each repeat unit contains a thioester functional group, dynamic rearrangement of the polymer is feasible v

NOVEL COMPOUND, AGENT AND NK3 RECEPTOR ANTAGONIST

PROBLEM TO BE SOLVED: To provide a NK3 receptor antagonist that inhibits the propagation of animals without adverse effect on an ecological system. SOLUTION: The present invention provides a compound represented by formula (I') (R1 is H, a hydroxy group or the like; R2 is a hydroxy group, a mercapto group or the like; R3 is a phenyl group or naphthyl group). SELECTED DRAWING: None COPYRIGHT: (C)2017,JPOandINPIT

Aziridine-mediated ligation and site-specific modification of unprotected peptides

A synthesis of aziridine-containing peptides via the Cu(II)-promoted coupling of unprotected peptide thioacids and N-H aziridine-2-carbonyl peptides is reported. The unique reactivity of the resulting N-acylated aziridine-2-carbonyl peptides facilitates t

Development of a novel benzyl mercaptan as a recyclable odorless substitute of hydrogen sulfide

2,4,6-Trimethoxybenzyl mercaptan (4) was developed as an odorless substitute of hydrogen sulfide to afford β-mercapto carbonyl compounds in a Michael addition and to convert alkyl bromides into alkanethiols. Detrimethoxybenzylation of the Michael adducts prepared from 4 and α,β-unsaturated esters or ketones was facilely carried out by treatment with a solvent mixture of trifluoroacetic acid and toluene to give β-mercapto carbonyl compounds. Successive alkaline hydrolysis of 2,4,6-trimethoxybenzyl isothiouronium salt, which was obtained as a side product, regenerated 4 accompanying disulfide 8 in good yield. The disulfide 8 was also converted into 4 by reduction with LiAlH4. A similar protocol was applicable to the synthesis of alkanethiols using the S N2 reaction of alkyl bromides. Our method could be complementary to the classical method of using malodorous benzyl mercaptan as a nucleophile and Birch reduction for debenzylation. Georg Thieme Verlag Stuttgart.

Direct synthesis of di- and trimethoxybenzyl thiols from the corresponding alcohol

An efficient and reliable procedure for the one-pot synthesis of di- and trimethoxybenzyl thiols from the corresponding benzyl alcohol is described.