215034-79-0Relevant articles and documents
5-Imidazolyl-quinolinones, -quinazolinones and -benzo-azepinones as farnesyltransferase inhibitors
Angibaud, Patrick,Bourdrez, Xavier,Devine, Ann,End, David W.,Freyne, Eddy,Ligny, Yannick,Muller, Philippe,Mannens, Geert,Pilatte, Isabelle,Poncelet, Virginie,Skrzat, Stacy,Smets, Gerda,Van Dun, Jacky,Van Remoortere, Pieter,Venet, Marc,Wouters, Walter
, p. 1543 - 1547 (2007/10/03)
The evaluation of structure-activity relationships associated with the modification of the R115777 quinolinone ring moiety displaying potent in vitro inhibiting activity is described.
Farnesyltransferase inhibiting quinazolinones
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, (2008/06/13)
This invention concerns compounds of formula the pharmaceutically acceptable acid addition salts and the stereochemically isomeric forms thereof, wherein the dotted line represents an optional bond; X is oxygen or sulfur; R1and R2eac