7497-60-1

Basic information

• Product Name: 4-CHLORO-4'-NITROBENZOPHENONE
• Synonyms: 4-CHLORO-4'-NITROBENZOPHENONE;NSC406624
• CAS NO: 7497-60-1
• Molecular Formula: C₁₃H₈ClNO₃
• Molecular Weight: 261.66
• Mol File: 7497-60-1.mol
• Article Data: 39

Chemical Properties

• Boiling Point: 425.9 °C at 760 mmHg
• Flash Point: 211.4 °C
• Appearance: /
• Density: 1.367 g/cm³
• Vapor Pressure: 1.85E-07mmHg at 25°C
• Refractive Index: 1.623
• CAS DataBase Reference: 4-CHLORO-4'-NITROBENZOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLORO-4'-NITROBENZOPHENONE(7497-60-1)
• EPA Substance Registry System: 4-CHLORO-4'-NITROBENZOPHENONE(7497-60-1)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 7497-60-1(Hazardous Substances Data)

Usage

General Description

4-CHLORO-4'-NITROBENZOPHENONE is a chemical compound with the molecular formula C13H8ClNO3. It is a yellow crystalline powder that is commonly used as a reagent in organic synthesis and pharmaceutical research. 4-CHLORO-4'-NITROBENZOPHENONE is known for its strong electron-withdrawing and electron-donating capabilities, and it is often used as a building block in the synthesis of various pharmaceuticals and agrochemicals. Additionally, it has been studied for its potential biological activities, including its antiproliferative and anticancer properties. 4-CHLORO-4'-NITROBENZOPHENONE is considered to be a versatile and valuable chemical compound in the field of organic chemistry.

InChI:InChI=1/C13H8ClNO3/c14-11-5-1-9(2-6-11)13(16)10-3-7-12(8-4-10)15(17)18/h1-8H

Upstream product

• 636-98-6 p-nitrobenzene iodide 
• 201230-82-2 carbon monoxide 
• 14064-15-4 (4-chlorophenyl)trimethylstannane 
• 1802-38-6 4-chlorophenylmercury chloride 
• 122-04-3 4-nitro-benzoyl chloride 
• 108-90-7 chlorobenzene 
• 30203-94-2 1-chloro-4-(4-nitrobenzyl)benzene 
• 555-16-8 4-nitrobenzaldehdye 
• 106-39-8 bromochlorobenzene 
• 1679-18-1 4-Chlorophenylboronic acid 
• 98-95-3 nitrobenzene 
• 13940-94-8 (4-chlorophenyl)dichloromethane 
• 14062-24-9 4-chloro-benzeneacetic acid, ethyl ester 
• 52449-43-1 (4-chloro-phenyl)-acetic acid methyl ester 

Downstream Products

• 7501-61-3 4,4'-Di-(4-chlorbenzoyl)-azoxy-benzol 
• 4913-77-3 4-amino-4'-chlorobenzophenone 
• 190898-64-7 2-(4-Chlorophenyl)-2-(4-nitrophenyl)-1,3-dioxolane 
• 42019-78-3 4-chloro-4'-hydroxybenzophenone 
• 1207471-78-0 [1-(4-chlorophenyl)-2,2,2-trifluoro-1-(4-nitrophenyl)-ethoxy]-(trimethyl)silane 
• 192185-72-1 tipifarnib 
• 192185-68-5 6-[amino(4-chlorophenyl)-1-methyl-1H-imidazol-5-ylmethyl]-4-(3-chlorophenyl)-1-methyl-2(1H)-quinolinone 
• 192185-51-6 4-(3-chlorophenyl)-6-[(4-chlorophenyl)hydroxy(1-methyl-1H-imidazol-5-yl)methyl]-1-methyl-2(1H)-quinolinone 
• 405548-67-6 N-[2-(3-chlorobenzoyl)-4-(4-chlorobenzoyl)phenyl]acetamide 
• 192187-32-9 R₁₀₁₇₆₃ 
• 192187-33-0 R₁₀₄₂₀₉ 
• 190898-77-2 3-(3-chlorophenyl)-5-[2-(4-chlorophenyl)-1,3-dioxolan-2-yl]-2,1-benzisoxazole 
• 190898-78-3 [2-amino-5-(4-chlorobenzoyl)phenyl](3-chlorophenyl)-methanone 
• 37567-38-7 4-chloro-3,4'-dinitro benzophenone 

Relevant articles and documents

Dirhodium-Catalyzed Enantioselective B?H Bond Insertion of gem-Diaryl Carbenes: Efficient Access to gem-Diarylmethine Boranes

The scarcity of reliable methods for synthesizing chiral gem-diarylmethine borons limits their applications. Herein, we report a method for highly enantioselective dirhodium-catalyzed B?H bond insertion reactions with diaryl diazomethanes as carbene precursors. These reactions afforded chiral gem-diarylmethine borane compounds in high yield (up to 99 % yield), high activity (turnover numbers up to 14 300), high enantioselectivity (up to 99 % ee) and showed unprecedented broad functional group tolerance. The borane compounds synthesized by this method could be efficiently transformed into diaryl methanol, diaryl methyl amine, and triaryl methane derivatives with good stereospecificity. Mechanistic studies suggested that the borane adduct coordinated to the rhodium catalyst and thus interfered with decomposition of the diazomethane, and that insertion of a rhodium carbene (generated from the diaryl diazomethane) into the B?H bond was most likely the rate-determining step.

Recyclable polyetheretherketone fiber-supported N-heterocyclic carbene catalysts for nucleophilic acylation of fluorobenzenes

We report for the first time a novel support of polyetheretherketone fiber for the synthesis of recyclable N-heterocyclic carbene (NHC) catalysts. The fiber catalysts were verified in nucleophilic acylation of fluorobenzenes with superior catalytic activities, and successfully recycled by a tiny pair of tweezers over 21 cycles with minimal loss of performance.

α-Chlorobenzylation of Nitroarenes via Vicarious Nucleophilic Substitution with Benzylidene Dichloride: Umpolung of the Friedel-Crafts Reaction

Readily available α,α-dichlorotoluenes enter a vicarious nucleophilic substitution (VNS) reaction with electron-deficient arenes to give α-chlorobenzylated nitrobenzenes, as well as six- and five-membered heterocycles. Oxidation of the initially formed α-chlorobenzylic carbanions instead of protonation results in formation of diaryl ketones, providing a means for overall nucleophilic C-H benzoylation of electron-deficient aromatic rings. Alternatively, benzoylated nitroarenes can be obtained via the reaction of isolated α-chlorodiarylmethanes with sodium azide.