cas 21566-74-5, 5-(2-aminoadipyl)cysteinylvaline

Articles about 21566-74-5Total 7 be found

Biosynthesis of penicillins: formation of 5-(2-aminoadipyl)-cysteinyl-valine in extracts of Penicillium chrysogenum
-
Bauer
p. 1125 - 1129
(1970)
Read Online

Exchange of the valine 2-H in the biosynthesis of L-δ-(α-aminoadipoyl)-L-cysteinyl-D-valine
Incubation of [2-2H]-valine with purified ACV synthetase from both Cephalosporium acremonium and Streptomyces davuligerus produced L-δ-(α-aminoadipoyl)-L-cysteinyl-D-valine (ACV), determined by the essentially complete (>95%) loss of deuterium from the α position of the incorporated valine. Incubations with deuterium oxide/water as solvent produced ACV with significant incorporation of deuterium into the valinyl residue. These observations confirm the prior proposal that a single multifunctional enzyme is responsible for both the formation of the peptide bonds of ACV and the epimerisation of the valinyl residue.
Baldwin, Jack E.,Byford, Michael F.,Field, Robert A.,Shiau, Chia-Yang,Sobey, Wendy J.,Schofield, Christopher J.
p. 3221 - 3226
(2007/10/02)

δ-(L-α-Aminoadipyl)-L-cysteinyl-D-valine Synthetase (ACV Synthetase): A Multifunctional Enzyme with Broad Substrate Specificity for the Synthesis of Penicillin and Cephalosporin Precursors
-
Banko, Gerald,Demain, Arnold L.,Wolfe, Saul
p. 2858 - 2860
(2007/10/02)

The synthesis and reactions of a monocyclic β-lactam tripeptide 1-[(1R)-carboxy-2-methylpropyl]-(3R)-[(5S)-5-amino-5-carboxypentanamido]-( 4R)-mercaptoazetidin-2-one, a putative intermediate in penicillin biosynthesis
-
Baldwin,Abraham,Adlington,et al.
p. 1907 - 1918
(2007/10/02)

Synthesis of δ-(L-α-Aminoadipyl)-L-cysteinyl-D-valine and δ-(L-α-Aminoadipyl)-L-cysteinyl-D-valylglycine
An efficient synthesis of δ-(L-α-aminoadipyl)-L-cysteinyl-D-valine (ACV; 1) and δ-(L-α-aminoadipyl)-L-cysteinyl-D-valylglycine (ACVG; 2) via the protected tripeptide N-benzyloxycarbonyl-1-(p-nitrobenzyl)-δ-(L-α-aminoadipyl)-S-benzyl-L-cysteinyl-D-valine,
Thomson, Gordon A.,Scott, A. Ian,Baxter, Robert L.
p. 941 - 944
(2007/10/02)

Conversion of 17O/18O-Labelled &δ-(L-&α-Aminoadipyl)-L-cysteinyl-D-valine into 17O/18O-Labelled Isopenicillin N in a Cell-free Extract of C. acremonium
δ-(L-α-Amino17O/18O>-adipyl)-L-cysteinyl-D-valine was converted into isopenicillin N in cell-free extracts of Cephalosporium acremonium with no loss of 17O/18O label as shown by 17O n.m.r. spectroscopy and mass spectrometry; incubation of unlabelled tripeptide in a cell-free system containing 17O/18O-enriched water produced isopenicillin N with no incorporation of 17O/18O.
Adlington, Robert M.,Aplin, Robin T.,Baldwin, Jack E.,Field, Leslie D.,John, Eeva-M. M.,et al.
p. 137 - 139
(2007/10/02)

Synthesis of δ-(L-α-Aminoadipoyl)-L-cysteinyl-D-valine and some Carbon-13 and Nitrogen-15 Labelled Isotopomers
δ-(L-α-Aminoadipoyl)-L-cysteinyl-D-valine (7a), δ-(L-α-aminoadipoyl)-L-cysteinyl-D-valine (7b), δ-(L-α-aminoadipoyl)-L-cysteinyl-D-valine (7c), and δ-(L-α-aminoadipoyl)-L-cysteinyl-D-valine (7d) were prepared by conv
Baldwin, Jack E.,Herchen, Stephen R.,Johnson, Brian L.,Jung, Mankil,Usher, John J.,Wan, Terence
p. 2253 - 2257
(2007/10/02)