21709-18-2

Basic information

• Product Name: CarboniMidic dichloride, (2,6-dichlorophenyl)-
• Synonyms: CarboniMidic dichloride, (2,6-dichlorophenyl)-;N-(2,6-Dichlorophenyl)-carbonimidic Dichloride
• CAS NO: 21709-18-2
• Molecular Formula: C₇H₃Cl₄N
• Molecular Weight: 242.91742
• Mol File: 21709-18-2.mol

Chemical Properties

• Boiling Point: 298.9°C at 760 mmHg
• Flash Point: 134.6°C
• Appearance: /
• Density: 1.53g/cm³
• Vapor Pressure: 0.00219mmHg at 25°C
• Refractive Index: 1.592
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility: Chloroform (Slightly), Ethyl Acetate (Slightly)
• Stability: Moisture Sensitive
• CAS DataBase Reference: CarboniMidic dichloride, (2,6-dichlorophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: CarboniMidic dichloride, (2,6-dichlorophenyl)-(21709-18-2)
• EPA Substance Registry System: CarboniMidic dichloride, (2,6-dichlorophenyl)-(21709-18-2)

Safety Data

• Hazardous Substances Data: 21709-18-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Carbonimidic dichloride, (2,6-dichlorophenyl)is used as an impurity in the production of clonidine, an α2-adrenergic agonist. Its presence is significant due to the therapeutic applications of clonidine in treating high blood pressure and neuropathic pain. The compound plays a role in the synthesis process of clonidine, which contributes to its overall effectiveness as a medication.
1. Antihypertensive Applications:
Clonidine, which contains Carbonimidic dichloride, (2,6-dichlorophenyl)as an impurity, is used as an antihypertensive agent. It helps in lowering blood pressure by stimulating the α2-adrenergic receptors, leading to a decrease in heart rate and blood vessel constriction.
2. Analgesic for Neuropathic Pain:
Clonidine, with Carbonimidic dichloride, (2,6-dichlorophenyl)as an impurity, is also utilized as an analgesic for neuropathic pain. It aids in reducing pain signals transmitted by the nervous system, providing relief to patients suffering from various types of neuropathic pain conditions.

InChI:InChI=1/C7H3Cl4N/c8-4-2-1-3-5(9)6(4)12-7(10)11/h1-3H

Upstream product

• 10113-35-6 N-(2,6-dichlorophenyl)-formamide 
• 608-31-1 2,6-Dichloroaniline 
• 10468-16-3 2-chloro-N-hydroxybenzenamine 
• 109384-39-6 N-(o-chlorophenyl)formohydroxamic acid 

Downstream Products

• 114143-70-3 2-<(2,6-dichlorophenyl)imino>-1,3-bis(3,4-dimethoxybenzyl)-4-<<(2-tetrahydropyranyl)oxy>methyl>imidazolidine 
• 96939-15-0 [2-(2,6-Dichloro-phenylamino)-4,5-dihydro-imidazol-1-yl]-thiophen-2-yl-acetic acid 
• 114143-73-6 2-<(2,6-dichlorophenyl)imino>-4-<<<3-(tert-butylamino)-2-hydroxypropyl>oxy>methyl>imidazolidine 
• 114143-71-4 2-<(2,6-dichlorophenyl)imino>-1,3-bis(3,4-dimethoxybenzyl)-4-(hydroxymethyl)imidazolidine 
• 114143-72-5 2-<(2,6-dichlorophenyl)imino>-1,3-bis(3,4-dimethoxybenzyl)-4-<<<3-(tert-butylamino)-2-hydroxypropyl>oxy>methyl>imidazolidine 
• 1273585-26-4 (Z)-2-(2,6-dichlorophenylimino)-4,5-diphenyl-1,3-oxathiole 
• 68560-68-9 (2,6-dichloro-phenyl)-(4-methyl-4,5-dihydro-1H-imidazol-2-yl)-amine 
• 4205-90-7 Clonidin 
• 6697-95-6 1,3-dichloro-2-isocyanobenzene 

Relevant articles and documents

A preparation method of the clonidine hydrochloride

The invention discloses a method for preparing the clonidine hydrochloride, including intermediates 1 synthesis, intermediate 2 synthesis and clonidine hydrochloride synthetic three steps, the present invention in order to 2, 6 - dichloroaniline as raw materials, through the hydroformylation reaction get intermediate 1, "one-pot" get clonidine free base, finally with hydrogen chloride ethanol solution into salt clonidine hydrochloride. By processing the raw material synthetic process, by utilizing the free alkali in the course of refining into salt after adjusting pH, and the clonidine hydrochloride is used for purification of the pulping process control such as ethyl acetate, to obtain a high-purity clonidine hydrochloride preparation method. The method not only improves the product purity and yield, impurity can also effectively control, but also greatly reducing the cost, simplifying the process, is more suitable for industrial production.

Methylation of imidazoline related compounds leads to loss of α2-adrenoceptor affinity. Synthesis and biological evaluation of selective I1 imidazoline receptor ligands

Methylated analogues of imidazoline related compounds (IRC) were prepared; their abilities to bind I1 imidazoline receptors (I1Rs), I2 imidazoline binding sites (I2BS) and α2-adrenoceptor subtypes (α

A Novel Synthesis of Clonidine, an Anti-Hypertensive Drug from o-Chloronitrobenzene

An elegant, cost-effective synthesis of clonidine (4) is reported from readily available starting materials. o-Chlorophenylhydroxylamine (2), obtained from o-chloronitrobenzene, is formylated to N-(2-chlorophenyl)-N-hydroxyformamide (3).In a one-pot procedure, 3 is converted to clonidine by chlorination with thionyl chloride and then with thionyl chloride/sulfuryl chloride, followed by condensation with ethylenediamine.

3-Anilino-2,4-diazabicyclo[3.2.1]octenes

Novel 3-anilino-2,4-diazabicyclo[3.2.1]octenes, physiologically tolerable acid addition salts thereof and method of preparing same are described. These compounds are useful as tranquilizers, diuretics and antihypertensives.