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CAS

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218770-02-6

3-Pyridinol,6-chloro-2-methyl-(9CI) is a chlorinated derivative of pyridinol, a chemical compound with the molecular formula C6H6ClNO and a molecular weight of 143.57 g/mol. It is commonly used in the pharmaceutical industry as a building block for the synthesis of various biologically active molecules, particularly in medicinal chemistry for the development of new drugs and pharmaceuticals.

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  • 218770-02-6 Structure

  • Basic information

    1. Product Name: 3-Pyridinol,6-chloro-2-methyl-(9CI)
    2. Synonyms: 3-Pyridinol,6-chloro-2-methyl-(9CI);6-Chloro-2-Methylpyridin-3-ol;6-Chloro-2-Methyl-3-pyridinol;5-Chloro-2-methyl-3-pyridinol 97%
    3. CAS NO:218770-02-6
    4. Molecular Formula: C6H6ClNO
    5. Molecular Weight: 143.57094
    6. EINECS: N/A
    7. Product Categories: PYRIDINE
    8. Mol File: 218770-02-6.mol

  • Chemical Properties

    1. Melting Point: 208℃
    2. Boiling Point: 332.8±37.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.313
    6. Refractive Index: N/A
    7. Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
    8. Solubility: N/A
    9. PKA: 9.92±0.10(Predicted)
    10. CAS DataBase Reference: 3-Pyridinol,6-chloro-2-methyl-(9CI)(CAS DataBase Reference)
    11. NIST Chemistry Reference: 3-Pyridinol,6-chloro-2-methyl-(9CI)(218770-02-6)
    12. EPA Substance Registry System: 3-Pyridinol,6-chloro-2-methyl-(9CI)(218770-02-6)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 218770-02-6(Hazardous Substances Data)

218770-02-6 Usage

Uses

Used in Pharmaceutical Industry:
3-Pyridinol,6-chloro-2-methyl-(9CI) is used as a building block for the synthesis of biologically active molecules, contributing to the development of new drugs and pharmaceuticals. Its specific properties and uses may vary depending on the intended application and the specific chemical processes it is involved in.
Used in Medicinal Chemistry:
3-Pyridinol,6-chloro-2-methyl-(9CI) is used as a key component in the development of new drugs and pharmaceuticals, leveraging its unique chemical properties to enhance the therapeutic potential of various medications. Its versatility in chemical synthesis allows for the creation of a wide range of biologically active compounds with diverse applications in healthcare.

Check Digit Verification of cas no

The CAS Registry Mumber 218770-02-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,1,8,7,7 and 0 respectively; the second part has 2 digits, 0 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 218770-02:
(8*2)+(7*1)+(6*8)+(5*7)+(4*7)+(3*0)+(2*0)+(1*2)=136
136 % 10 = 6
So 218770-02-6 is a valid CAS Registry Number.

218770-02-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 6-Chloro-2-methyl-3-pyridinol

1.2 Other means of identification

Product number -
Other names 6-chloro-2-(methylsulfanyl)pyrimidine-4-carboxamide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:218770-02-6 SDS

218770-02-6Downstream Products

218770-02-6Relevant articles and documents

GPR119 Receptor Agonists

-

Page/Page column 19, (2009/12/05)

Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of metabolic diseases and disorders such as, for example, type II diabetes mellitus.

Structure-activity studies related to ABT-594, a potent nonopioid analgesic agent: Effect of pyridine and azetidine ring substitutions on nicotinic acetylcholine receptor binding affinity and analgesic activity in mice

Holladay, Mark W.,Bai, Hao,Li, Yihong,Lin, Nan-Horng,Daanen, Jerome F.,Ryther, Keith B.,Wasicak, James T.,Kincaid, John F.,He, Yun,Hettinger, Anne-Marie,Huang, Peggy,Anderson, David J.,Bannon, Anthony W.,Buckley, Michael J.,Campbell, Jeffrey E.,Donnelly-Roberts, Diana L.,Gunther, Karen L.,Kim, David J. B.,Kuntzweiler, Theresa A.,Sullivan, James P.,Decker, Michael W.,Arneric, Stephen P.

, p. 2797 - 2802 (2007/10/03)

Analogs of A-98593 (1) and its enantiomer ABT-594 (2) with diverse substituents on the pyridine ring were prepared and tested for affinity to nicotinic acetylcholine receptor binding sites in rat brain and for analgesic activity in the mouse hot plate assay. Numerous types of modifications were consistent with high affinity for [3H]cytisine binding sites. By contrast, only selected modifications resulted in retention of analgesic potency in the ame range as 1 and 2. Analogs of 2 with one or two methyl substituents at the 3-position of the azetidine ring also were prepared and found to be substantially less active in both assays.

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