220107-65-3

Basic information

• Product Name: 2-Amino-5-(trifluoromethyl)benzyl alcohol
• Synonyms: 2-Amino-5-(trifluoromethyl)benzyl alcohol;2-Amino-5-(trifluoromethyl)benzenemethanol
• CAS NO: 220107-65-3
• Molecular Formula: C₈H₈F₃NO
• Molecular Weight: 191.1504296
• Product Categories: Fluorine series
• Mol File: 220107-65-3.mol

Chemical Properties

• Boiling Point: 270℃
• Flash Point: 117℃
• Appearance: /
• Density: 1.374
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: 2-Amino-5-(trifluoromethyl)benzyl alcohol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Amino-5-(trifluoromethyl)benzyl alcohol(220107-65-3)
• EPA Substance Registry System: 2-Amino-5-(trifluoromethyl)benzyl alcohol(220107-65-3)

Safety Data

• Hazardous Substances Data: 220107-65-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research and Development:
2-Amino-5-(trifluoromethyl)benzyl alcohol is used as a key intermediate in the synthesis of various biologically active compounds. Its unique structure allows for the creation of pharmaceutical drugs with potential therapeutic applications.
Used in Organic Synthesis:
In the field of organic synthesis, 2-Amino-5-(trifluoromethyl)benzyl alcohol serves as a reagent, facilitating the production of a wide range of chemical compounds for research and commercial purposes.
Used in Agrochemical Development:
2-Amino-5-(trifluoromethyl)benzyl alcohol is also utilized in the development of agrochemicals, where its properties can contribute to the creation of effective and innovative products for agricultural applications.
Used in the Production of Commercial Products:
Due to its versatility, 2-Amino-5-(trifluoromethyl)benzyl alcohol finds use in the manufacturing process of various commercial products, enhancing their performance and functionality.

Upstream product

• 83265-53-6 2-amino-5-(trifluoromethyl)benzoic acid 
• 117324-58-0 methyl 2-Amino-5-trifluoromethylbenzoate 

Downstream Products

• 1288999-05-2 2-amino-5-(trifluoromethyl)benzaldehyde 
• 702641-05-2 [2-iodo-5-(trifluoromethyl)phenyl]methanol 

Relevant articles and documents

Enantioselective synthesis of tunable chiral pyridine-aminophosphine ligands and their applications in asymmetric hydrogenation

A small library of tunable chiral pyridine-aminophosphine ligands were enantioselectively synthesized based on chiral 2-(pyridin-2-yl)-substituted 1,2,3,4-tetrahydroquinoline scaffolds, which were obtained in high yields and with excellent enantioselectivities via ruthenium-catalyzed asymmetric hydrogenation of 2-(pyridin-2-yl)quinolines. The protocol features a wide substrate scope and mild reaction conditions, enabling scalable synthesis. These chiral P,N ligands were successfully applied in the Ir-catalyzed asymmetric hydrogenation of benchmark olefins and challenging seven-membered cyclic imines including benzazepines and benzodiazepines. Excellent enantio- and diastereoselectivity (up to 99% ee and >20:1 dr), and/or unprecedented chemoselectivity were obtained in the asymmetric hydrogenation of 2,4-diaryl-3H-benzo[b]azepines and 2,4-diaryl-3H-benzo[b][1,4]diazepines.

Synthesis of quinolinomorphinan derivatives as highly selective δ opioid receptor ligands

We have reported previously the novel δ opioid agonist KNT-127 which showed high affinity and selectivity for the δ receptor. Moreover, the analgesic effect of subcutaneously administered KNT-127 was more potent than that of a prototypical δ agonist (-)-TAN-67 in the acetic acid writhing test. This study of the structure-activity relationship of KNT-127 derivatives focused on the introduction of substituents onto the 5′-, 6′-, 7′- or 8′-position of the quinoline ring and revealed that many derivatives with 5′- or 8′-substituents showed high affinities and selectivities for the δ receptor. Especially, SYK-153 with an 8′-OH group showed the highest affinity and the most balanced and highest selectivity for the δ receptor among the synthesized compounds.

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