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CAS

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221246-44-2

2-[4-(3-fluoro-benzyloxy)-phenoxy]-5-nitro-pyridine is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 221246-44-2 Structure

  • Basic information

    1. Product Name: 2-[4-(3-fluoro-benzyloxy)-phenoxy]-5-nitro-pyridine
    2. Synonyms: 2-[4-(3-fluoro-benzyloxy)-phenoxy]-5-nitro-pyridine
    3. CAS NO:221246-44-2
    4. Molecular Formula: C18H13FN2O4
    5. Molecular Weight: 340
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 221246-44-2.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 2-[4-(3-fluoro-benzyloxy)-phenoxy]-5-nitro-pyridine(CAS DataBase Reference)
    10. NIST Chemistry Reference: 2-[4-(3-fluoro-benzyloxy)-phenoxy]-5-nitro-pyridine(221246-44-2)
    11. EPA Substance Registry System: 2-[4-(3-fluoro-benzyloxy)-phenoxy]-5-nitro-pyridine(221246-44-2)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 221246-44-2(Hazardous Substances Data)

221246-44-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 221246-44-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,2,1,2,4 and 6 respectively; the second part has 2 digits, 4 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 221246-44:
(8*2)+(7*2)+(6*1)+(5*2)+(4*4)+(3*6)+(2*4)+(1*4)=92
92 % 10 = 2
So 221246-44-2 is a valid CAS Registry Number.

221246-44-2Relevant articles and documents

Synthesis and structure-activity relationships of phenoxypyridine derivatives as novel inhibitors of the sodium-calcium exchanger

Kuramochi, Takahiro,Kakefuda, Akio,Yamada, Hiroyoshi,Sato, Ippei,Taguchi, Taku,Sakamoto, Shuichi

, p. 5039 - 5056 (2007/10/03)

A series of 2-phenoxypyridine derivatives were prepared and evaluated for their inhibitory activity against the reverse and forward modes of the sodium-calcium exchanger (NCX). The structure-activity relationships of these compounds on the inhibitory activity for the sodium-calcium exchanger are discussed. The sodium-calcium exchanger (NCX) is known as the transporter that controls the concentration of Ca2+ in cardiac myocytes. In the setting of heart failure and myocardial ischemia-reperfusion, NCX underlies an arrhythmogenic transient inward current responsible for delayed after-depolarizations and nonreentrant initiation of ventricular tachycardia. NCX is an attractive target for treatment in heart failure and myocardial ischemia-reperfusion. We have designed and synthesized a series of phenoxypyridine derivatives, based on compound 3. These derivatives have been evaluated for their inhibitory activity against both the reverse and forward mode of NCX in CCL39 cells. We have discovered several novel potent NCX inhibitors (39q, 48k), which have a high selectivity for reverse NCX inhibitory activity.

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