22237-13-4

Basic information

• Product Name: 4-ETHOXYPHENYLBORONIC ACID
• Synonyms: 4-Boronophenetole;Boronicacid, B-(4-ethoxyphenyl)-;RARECHEM AH PB 0138;P-ETHOXYPHENYLBORONIC ACID;4-ETHOXYPHENYLBORONIC ACID;4-ETHOXYBENZENEBORONIC ACID;AKOS BRN-0070;4-Ethoxybenzeneboronicacid,96%
• CAS NO: 22237-13-4
• Molecular Formula: C₈H₁₁BO₃
• Molecular Weight: 165.98214
• EINECS: -0
• Product Categories: blocks;BoronicAcids;Boronic Acid;Alkoxy;Aryl;Organoborons;B (Classes of Boron Compounds);Boronic Acids;Boronic Acids;Boronic Acids and Derivatives;Boronate Ester;Potassium Trifluoroborate
• Mol File: 22237-13-4.mol

Chemical Properties

• Melting Point: 121-128 °C(lit.)
• Boiling Point: 317.6 °C at 760 mmHg
• Flash Point: 145.9 °C
• Appearance: /solid
• Density: 1.13 g/cm³
• Storage Temp.: 0-6°C
• Solubility: soluble in Methanol
• PKA: 8.98±0.10(Predicted)
• BRN: 3530408
• CAS DataBase Reference: 4-ETHOXYPHENYLBORONIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4-ETHOXYPHENYLBORONIC ACID(22237-13-4)
• EPA Substance Registry System: 4-ETHOXYPHENYLBORONIC ACID(22237-13-4)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 36/37/38-22
• Safety Statements: 37/39-26-36
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 22237-13-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
4-Ethoxyphenylboronic acid is used as a reactant in the synthesis of biologically active molecules for the treatment of various diseases. It is involved in the production of novel modulators of survival motor neuron protein for the treatment of spinal muscular atrophy.
Used in Chemical Industry:
4-Ethoxyphenylboronic acid is used as a reactant in Suzuki cross-coupling reactions, a widely used method in organic synthesis for the formation of carbon-carbon bonds. This reaction is employed in the synthesis of various compounds, including:
Amino-trimethoxyphenyl-aryl thiazoles, which are used as microtubule inhibitors and antitumor agents.
Bicyclic hydroxyphenyl methanone derivatives, which are used as hydroxysteroid dehydrogenase inhibitors.
Dual immunosuppressive and anti-inflammatory agents.
Antiproliferatives via Suzuki cross-coupling / amination reactions.
Overall, 4-ethoxyphenylboronic acid is a valuable compound in the fields of pharmaceuticals and organic synthesis, contributing to the development of new drugs and chemical compounds with potential therapeutic applications.

Upstream product

• 2873-18-9 5-bromo-2-chlorothiophene 
• 588-96-5 4-bromoethoxybenzene 
• 688-74-4 boric acid tributyl ester 
• 41842-30-2 4-ethoxyphenylmagnesium bromide 
• 121-43-7 Trimethyl borate 
• 92838-44-3 Hg(C₆H₄-4-OC₂H₅)2 
• 7732-18-5 water 
• 1765-93-1 4-fluoroboronic acid 
• 75-03-6 ethyl iodide 

Downstream Products

• 503308-13-2 5-[3-chloro-5-(4-ethoxyphenyl)thiophen-2-yl]-3-(2-chloro-6-fluorophenyl)-1-methyl-1H-[1,2,4]triazole 
• 503308-08-5 5-[3-chloro-5-(4-ethoxyphenyl)thiophen-2-yl]-3-(2,6-difluorophenyl)-1-methyl-1H-[1,2,4]triazole 
• 503308-70-1 3-(2-chloro-6-fluorophenyl)-5-[5-(4-ethoxyphenyl)-3-methylthiophen-2-yl]-1-methyl-1H-[1,2,4]triazole 
• 503308-20-1 3-(2-chloro-6-fluorophenyl)-5-[4-(4-ethoxyphenyl)-3-methylthiophen-2-yl]-1-methyl-1H-[1,2,4]triazole 
• 952049-79-5 3-(2-chloro-6-fluorophenyl)-5-[4-(4-ethoxyphenyl)-3,5-dimethylthiophen-2-yl]-1-methyl-1H-[1,2,4]triazole 
• 952049-44-4 3-(2-chloro-6-fluorophenyl)-5-[5-(4-ethoxyphenyl)-3,4-dimethylthiophen-2-yl]-1-methyl-1H-[1,2,4]triazole 
• 503308-18-7 5-[4-bromo-3-chloro-5-(4-ethoxyphenyl)thiophen-2-yl]-3-(2-chloro-6-fluorophenyl)-1-methyl-1H-[1,2,4]triazole 
• 1178980-21-6 2-chloro-6-cyclopropyl-7-(4-ethoxyphenyl)-3-methylfuro[2,3-b]pyrazine 
• 1095984-88-5 (5R)-3-[(4'-ethoxybiphenyl-4-yl)methyl]-5-methyl-1,3-oxazolidin-2-one 
• 1258850-52-0 6-(4-ethoxyphenyl)-pyrazine-2-carboxylic acid 
• 1261379-92-3 (E)-4-((4'-ethoxy-3,5-diethylbiphenyl-4-yl)diazenyl)phenol 
• 1415638-50-4 N-(5-(4-ethoxyphenyl)-4-(3,4,5-trimethoxyphenyl)thiazol-2-yl)-N-methylacetamide 
• 1415638-34-4 C₂₂H₂₆N₂O₄S 
• 1442663-54-8 C₁₈H₁₉NO₃ 

Relevant articles and documents

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