223611-42-5Relevant articles and documents
Homoallylglycine residues are superior precursors to orthogonally modified thioether containing polypeptides
Perlin, Pesach,Gharakhanian, Eric G.,Deming, Timothy J.
, p. 6196 - 6199 (2018/06/18)
Homoallylglycine N-carboxyanhydride, Hag NCA, monomers were synthesized and used to prepare polypeptides containing Hag segments with controllable lengths of up to 245 repeats. Poly(l-homoallylglycine), GHA, was found to adopt an α-helical conf
COMPOSITIONS AND METHODS FOR INDUCING IMMUNE TOLERANCE
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Paragraph 0327, (2019/01/08)
Several embodiments provided in the present disclosure relate to compositions that carry an antigen to which tolerance is desired, the antigen being coupled, bound, or otherwise joined to a targeting moiety, the targeting moiety configured to direct the composition to the liver of a subject. In several embodiments, the antigen in coupled to the targeting moiety by way of a polymeric linker. In several embodiments, the polymeric linker is configured to liberate the antigen in vivo. Methods of using the compositions to reduce and/or prevent unwanted immune responses against an antigen of interest are also provided.
Kinetically Controlled Sequential Growth of Surface-Grafted Chiral Supramolecular Copolymers
Frisch, Hendrik,Fritz, Eva-Corinna,Stricker, Friedrich,Schmüser, Lars,Spitzer, Daniel,Weidner, Tobias,Ravoo, Bart Jan,Besenius, Pol
supporting information, p. 7242 - 7246 (2016/07/06)
We report a facile strategy to grow supramolecular copolymers on Au surfaces by successively exposing a surface-anchored monomer to solutions of oppositely charged peptide comonomers. Charge regulation on the active chain end of the polymer sufficiently slows down the kinetics of the self-assembly process to produce kinetically trapped copolymers at near-neutral pH. We thereby achieve architectural control at three levels: The β-sheet sequences direct the polymerization away from the surface, the height of the supramolecular copolymer brushes is well-controlled by the stepwise nature of the alternating copolymer growth, and 2D spatial resolution is realized by using micropatterned initiating monomers. The programmable nature of the resulting architectures renders this concept attractive for the development of customized biomaterials or chiral interfaces for optoelectronics and sensor applications.
Conjugation of multivalent ligands to gold nanoshells and designing a dual modality imaging probe
Bdard, Mathieu,Avti, Pramod K.,Lam, Tina,Rouleau, Lonie,Tardif, Jean-Claude,Rhaume, ric,Lesage, Frdric,Kakkar, Ashok
, p. 1788 - 1800 (2015/08/26)
Design and synthesis of branched tetraethylene glycol (TEG) based ligands for subsequent conjugation to gold nanoshells are reported. TEG enhances the aqueous solubility of hollow gold nanoshells (HAuNShs), and the branched architecture provides stability
Highly efficient synthesis of monodisperse poly(ethylene glycols) and derivatives through macrocyclization of oligo(ethylene glycols)
Zhang, Hua,Li, Xuefei,Shi, Qiuyan,Li, Yu,Xia, Guiquan,Chen, Long,Yang, Zhigang,Jiang, Zhong-Xing
, p. 3763 - 3767 (2015/03/18)
A macrocyclic sulfate (MCS)-based approach to monodisperse poly(ethylene glycols) (M-PEGs) and their monofunctionalized derivatives has been developed. Macrocyclization of oligo(ethylene glycols) (OEGs) provides MCS (up to a 62-membered macrocycle) as versatile precursors for a range of monofunctionalized M-PEGs. Through iterative nucleophilic ring-opening reactions of MCS without performing group protection and activation, a series of M-PEGs, including the unprecedented 64-mer (2850Da), can be readily prepared. Synthetic simplicity coupled with versatility of this new strategy may pave the way for broader applications of M-PEGs. Macrocycles make synthesis easier: Convenient macrocyclization of the OEGs provides versatile macrocyclic sulfates. These compounds are cornerstones for both monofunctionalization of OEGs and highly efficient synthesis of monodisperse PEGs and derivatives, including an unprecedented 64-mer.
Synthesis of galactoclusters by metal-free thiol "click chemistry" and their binding affinities for pseudomonas aeruginosa lectin leca
Ligeour, Caroline,Dupin, Lucie,Marra, Alberto,Vergoten, Gérard,Meyer, Albert,Dondoni, Alessandro,Souteyrand, Eliane,Vasseur, Jean-Jacques,Chevolot, Yann,Morvan, Fran?ois
, p. 7621 - 7630 (2015/04/22)
Mannose-centered galactoclusters specific for lectin I of Pseudomonas aeruginosa (LecA) were synthesised by a combination of phosphoramidite chemistry and metal-free thiol click chemistry (i.e., thiol addition to acrylamide or nucleophilic displacement of
Miktoarm star conjugated multifunctional gold nanoshells: Synthesis and an evaluation of biocompatibility and cellular uptake
Ng, Vanessa W. K.,Avti, Pramod K.,Bedard, Mathieu,Lam, Tina,Rouleau, Leonie,Tardif, Jean-Claude,Rheaume, Eric,Lesage, Frederic,Kakkar, Ashok
, p. 6334 - 6344 (2014/12/11)
A simple and highly versatile click chemistry based synthetic strategy to develop an ABC type miktoarm star ligand that is conjugated to gold nanoshells (GNS) is reported. The surface functionalized multifunctional GNS contain lipoic acid (LA) as a model
Recognition of lectin with a high signal to noise ratio: Carbohydrate-tri(ethylene glycol)-alkanethiol co-adsorbed monolayer
Sato, Yukari,Yoshioka, Kyoko,Tanaka, Mutsuo,Murakami, Teiichi,Ishida, Miho Neide,Niwa, Osamu
supporting information; experimental part, p. 4909 - 4911 (2009/06/06)
Densely packed co-adsorbed ultrathin mono molecular layers of short tri(ethylene glycol)-alkanethiolate (for repelling proteins) and maltoside terminated alkanethiolate (for capturing lectin) provided an extremely high signal to noise ratio surface: the r
Gold glyconanoparticles: Synthetic polyvalent ligands mimicking glycocalyx-like surfaces as tools for glycobiological studies
Barrientos, Africa G.,De la Fuente, Jesus M.,Rojas, Teresa C.,Fernandez, Asuncion,Penades, Soledad
, p. 1909 - 1921 (2007/10/03)
A simple and versatile methodology is described for tailoring sugar-functionalised gold nanoclusters (glyconanoparticles) that have 3D polyvalent carbohydrate display and globular shapes. This methodology allows the preparation of glyconanoparticles with biologically significant oligosaccharides as well as with differing carbohydrate density. Fluorescent glyconanoparticles have been also prepared for labelling cells in biological tests. The materials are water soluble, stable under physiological conditions and present an exceptional small core size. All of them have been characterised by 1H NMR, UV and IR spectroscopy, TEM and elemental analysis. Their highly polyvalent network can mimic glycosphingolipid clustering and interactions at the plasma membrane, providing an controlled system for glycobiological studies. Furthermore, they are useful building blocks for the design of nanomaterials.
Dynamic light scattering evidence for a ligand-induced motion between the two domains of glucoamylase G1 of Aspergillus niger with heterobivalent substrate analogues
Payre, Nathalie,Cottaz, Sylvain,Boisset, Claire,Borsali, Redouane,Svensson, Birte,Henrissat, Bernard,Driguez, Hugues
, p. 974 - 977 (2007/10/03)
Heterobifunctional ligands that bind at the same time to the catalytic domain and to the starch-binding domain of glucoamylase induce a conformational change of the protein, as shown by dynamic light scattering. The ligands consist of acarbose and β-cyclo
