22479-46-5Relevant articles and documents
Nickel-Catalyzed Desymmetrizing Cyclization of 1,6-Dienes to Construct Quaternary Stereocenters
Zhao, Tian-Yuan,Li, Ke,Yang, Liang-Liang,Zhu, Shou-Fei,Zhou, Qi-Lin
supporting information, p. 3814 - 3817 (2021/05/26)
A highly enantioselective and diastereoselective nickel-catalyzed desymmetrizing cyclization of 1,6-dienes was developed by using chiral spiro phosphoramidite ligands. The reaction provides a new atom- and step-economical approach to chiral spiro lactones and analogues bearing a quaternary stereocenter.
MODULATORS OF HEMOGLOBIN
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Paragraph 0124-0125, (2021/10/11)
The present disclosure relates generally to compounds and pharmaceutical compositions suitable as modulators of hemoglobin and methods for their use in treating disorders mediated by hemoglobin. (Formula (I))
Fukuyama Cross-Coupling Approach to Isoprekinamycin: Discovery of the Highly Active and Bench-Stable Palladium Precatalyst POxAP
Tang, Shuang-Qi,Bricard, Jacques,Schmitt, Martine,Bihel, Frédéric
supporting information, p. 844 - 848 (2019/01/30)
An efficient and user-friendly palladium(II) precatalyst, POxAP (post-oxidative-addition precatalyst), was identified for use in Fukuyama cross-coupling reactions. Suitable for storage under air, the POxAP precatalyst allowed reaction between thioesters and organozinc reagents with turnover numbers of ~90000. A series of 23 ketones were obtained with yields ranging from 53 to 99%. As proof of efficacy, an alternative approach was developed for the synthesis of a key precursor of the natural product isoprekinamycin.
Highly chemoselective esterification reactions and Boc/THP/TBDMS discriminating deprotections under samarium(III) catalysis
Gopinath, Pushparathinam,Nilaya, Surapaneni,Muraleedharan, Kannoth Manheri
supporting information; experimental part, p. 1932 - 1935 (2011/06/21)
The usefulness of SmCl3 as an excellent catalyst for chemoselective esterifications and selective removal of acid sensitive protecting groups such as Boc, THP, and TBDMS in the presence of one another is demonstrated through suitable examples.
A highly convenient, efficient, and selective process for preparation of esters and amides from carboxylic acids using Fe3+-K-10 montmorillonite clay
Srinivas,Das, Biswanath
, p. 1165 - 1167 (2007/10/03)
In the presence of Fe3+-K-10 montmorillonite clay as a catalyst, aliphatic carboxylic acids selectively produced the corresponding esters in the presence of aromatic carboxylic acids by treatment with alcohols. Both the aliphatic and aromatic carboxylic acids formed the amides by reacting with the aliphatic amines, but only the aliphatic carboxylic acids yielded the anilides by treatment with aromatic amines. The catalyst is recoverable and recyclable.
Selective transesterification of aliphatic acids in the presence of aromatic acids using silica gel supported NaHSO4 catalyst
Das,Venkataiah
, p. 1671 - 1672 (2007/10/03)
Acidolysis of EtOAc in the presence of silica gel supported NaHSO4 catalyst has been applied for the protection of aliphatic nonconjugated carboxylic acids through the formation of esters.
A Simple and Efficient Selective Esterification of Aliphatic Carboxylic Acids in the Presence of Aromatic Carboxylic Acids
Das, Biswanath,Venkataiah, B.,Madhusudhan, P.
, p. 59 - 60 (2007/10/03)
Aliphatic carboxylic acids were esterificated selectively at room temperature in the presence of aromatic carboxylic acids by treatment with alcohols in the presence of silica gel supported NaHSO4 catalyst.
Ring opening of cyclic anhydrides: Synthesis of achiral half-esters using Lewis acids
Sabitha, Gowravaram,Srividya,Yadav
, p. 4015 - 4018 (2007/10/03)
A rapid and high yield preparation of half-esters from cyclic anhydrides using alcohols and Lewis acids is described.
Intramolecular Diels-Alder reaction of 1-aminoisobenzofurans: Application to the synthesis of benzo [c]phenanthridines
Bernabe, Pablo,Castedo, Luis,Dominguez, Domingo
, p. 9785 - 9788 (2007/10/03)
Intramolecular Diels-Alder reactions of 1-aminoisobenzofurans give benzo[c)phenanthridines. The reactive intermediates are generated from o- (diazomethyl)benzamides.
THE REGIO- AND STEREOCHEMISTRY OF THE ALKOXIDE-INDUCED RING-OPENING OF METHOXYMETHYLIDENE-SUBSTITUTED HOMOPHTHALIC ANHYDRIDE
Hutchings, Michael G.,Chippendale, A. Margaret,Ferguson, Ian
, p. 3727 - 3734 (2007/10/02)
Ring-opening of methoxymethylidene-substituted homophthalic anhydride (1) by methoxide occurs by two modes.Attack at the 1-position ("benzoate" carbonyl) leads to a stable acid-ester.A combination of unambiguous syntheses and 1H- and 13C-n.m.r. spectrosco