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4-NITROPHENYL-2-METHOXYETHYL ETHER is a chemical compound characterized by the molecular formula C9H11NO4. It is a nitrophenyl ether known for its role as a protecting group for alcohols in the realm of organic synthesis. This colorless to light yellow crystalline solid exhibits slight solubility in water and is predominantly utilized in the pharmaceutical and chemical industries, capitalizing on its properties to facilitate organic synthesis reactions. It also holds potential for use in the creation of agrochemicals and specialty chemicals, although its handling requires caution due to its potential hazardous nature.

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  • 22483-40-5 Structure
  • Basic information

    1. Product Name: 4-NITROPHENYL-2-METHOXYETHYL ETHER
    2. Synonyms: 4-NITROPHENYL-2-METHOXYETHYL ETHER;1-(2-Methoxyethoxy);Benzene, 1-(2-methoxyethoxy)-4-nitro-
    3. CAS NO:22483-40-5
    4. Molecular Formula: C9H11NO4
    5. Molecular Weight: 376.3606
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 22483-40-5.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 503.8 °C at 760 mmHg
    3. Flash Point: 196.2 °C
    4. Appearance: /
    5. Density: 1.283 g/cm3
    6. Vapor Pressure: 0.000736mmHg at 25°C
    7. Refractive Index: 1.525
    8. Storage Temp.: Sealed in dry,Room Temperature
    9. Solubility: N/A
    10. CAS DataBase Reference: 4-NITROPHENYL-2-METHOXYETHYL ETHER(CAS DataBase Reference)
    11. NIST Chemistry Reference: 4-NITROPHENYL-2-METHOXYETHYL ETHER(22483-40-5)
    12. EPA Substance Registry System: 4-NITROPHENYL-2-METHOXYETHYL ETHER(22483-40-5)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 22483-40-5(Hazardous Substances Data)

22483-40-5 Usage

Uses

Used in Pharmaceutical Industry:
4-NITROPHENYL-2-METHOXYETHYL ETHER is used as a protecting group for alcohols in organic synthesis, facilitating the production of various pharmaceutical compounds. Its ability to shield alcohol groups during chemical reactions allows for selective reactions to occur, enhancing the synthesis process and yielding desired products more efficiently.
Used in Chemical Industry:
In the chemical industry, 4-NITROPHENYL-2-METHOXYETHYL ETHER serves as a crucial component in the synthesis of a range of chemical products. Its function as a protecting group aids in the controlled formation of complex molecules, which is vital for the development of specialty chemicals with specific applications.
Used in Agrochemical Production:
4-NITROPHENYL-2-METHOXYETHYL ETHER is utilized in the production of agrochemicals, where its role as a protecting group in organic synthesis contributes to the creation of effective and targeted agricultural chemicals. This ensures the development of products that can be safely and effectively used in agricultural settings.
Used in Specialty Chemicals:
4-NITROPHENYL-2-METHOXYETHYL ETHER finds application in the realm of specialty chemicals, where its unique properties as a protecting group in organic synthesis reactions are harnessed to produce chemicals with specific, tailored properties for niche applications.

Check Digit Verification of cas no

The CAS Registry Mumber 22483-40-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,2,4,8 and 3 respectively; the second part has 2 digits, 4 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 22483-40:
(7*2)+(6*2)+(5*4)+(4*8)+(3*3)+(2*4)+(1*0)=95
95 % 10 = 5
So 22483-40-5 is a valid CAS Registry Number.
InChI:InChI=1/C9H11NO4/c1-13-6-7-14-9-4-2-8(3-5-9)10(11)12/h2-5H,6-7H2,1H3

22483-40-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-(2-methoxyethoxy)-4-nitrobenzene

1.2 Other means of identification

Product number -
Other names 4-Methoxyaethoxy-nitrobenzol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:22483-40-5 SDS

22483-40-5Relevant articles and documents

PROPENAMIDE THIOPHENE DERIVATIVES AS FLAVIVIRUS INHIBITORS AND THEIR USE

-

Page/Page column 24, (2017/07/06)

The present invention deals with new flavivirus inhibitors, compositions comprising said inhibitors and methods for the treatment of disorders related to a viral infection, such as a disease due to a flavivirus infection, comprising administering said inhibitors.

Eeyarestatin I derivatives with improved aqueous solubility

Ding, Rui,Zhang, Ting,Xie, Jiashu,Williams, Jessica,Ye, Yihong,Chen, Liqiang

supporting information, p. 5177 - 5181 (2016/11/09)

Inhibition of p97 (also known as valosin-containing protein (VCP)), has been validated as a promising strategy for cancer therapy. Eeyarestatin I (EerI) blocks p97 through a novel mechanism of action and has favorable anti-cancer activities against cultured cancer cells. However, its poor aqueous solubility severely limits its in vivo applications. To circumvent this problem, we have identified EerI derivatives that possess improved aqueous solubility by introducing a single solubilizing group. These modified compounds preserved endoplasmic reticulum (ER) stress-inducing and antiproliferative activities as well as generally good in vitro metabolic properties, suggesting that these EerI derivatives could serve as candidates for further optimization.

HETEROCYCLIC COMPOUNDS AND USES THEREOF

-

Paragraph 00243; 00244, (2015/02/02)

The present invention relates to pharmaceutical compounds, compositions and methods, especially as they are related to compositions and methods for the treatment and/or prevention of a proliferation disorder, a cancer, a tumor, an inflammatory disease, an autoimmune disease, psoriasis, dry eye or an immunologically related disease, and in some embodiments diseases or disorders related to the dysregulation of kinase such as, but not limited to, EGFR (including HER), Alk, PDGFR, BLK, BMX/ETK, FLT3(D835Y), ITK, TEC, TXK, BTK, or JAK, and the respective pathways.

TYK2 INHIBITORS AND USES THEREOF

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Paragraph 00768; 00769, (2015/09/28)

The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.

INHIBITORS OF BRUTON'S TYROSINE KINASE

-

Paragraph 00544; 00546, (2014/09/03)

Disclosed herein are compounds that form covalent bonds with Bruton's tyrosine kinase (Btk). Also described are irreversible inhibitors of Btk. In addition, reversible inhibitors of Btk are also described. Also disclosed are pharmaceutical compositions th

Chemokine receptor binding compounds

-

Page/Page column 17, (2008/06/13)

The present invention relates to chemokine receptor binding compounds, pharmaceutical compositions and their use. More specifically, the present invention relates to modulators of chemokine receptor activity, preferably modulators of CCR5. These compounds

1-benzenesulfonyl-1,3-dihydro-2H-benzimidazol-2-one derivatives

-

, (2008/06/13)

The present invention relates to 1-benzenesulfonyl-1,3-dihydro-2H-benzimidazol-2-one derivatives of the formula: STR1 to their preparation and to the pharmaceutical compositions in which they are present. These derivatives have an affinity for the vasopressin and oxytocin receptors.

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