33311-29-4Relevant articles and documents
S-triazine compounds as well as preparation method and application thereof
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Paragraph 0088-0090, (2020/05/05)
The invention discloses s-triazine compounds and pharmaceutically acceptable salts thereof; experiments prove that the compounds can be used for treating or preventing diseases related to protein kinase activity, such as leukemia and lymphoma, by inhibiti
As tyrosine kinase inhibitors containing nitrogen and ring compound
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Paragraph 0313; 0314; 0315; 0316, (2017/04/26)
The invention belongs to the technical field of medicine, particularly relates to a heterocyclic nitrogen compound which acts as a tyrosine kinase inhibitor and is represented by a general formula (I) as well as a deuterated material, pharmaceutically acc
Eeyarestatin I derivatives with improved aqueous solubility
Ding, Rui,Zhang, Ting,Xie, Jiashu,Williams, Jessica,Ye, Yihong,Chen, Liqiang
, p. 5177 - 5181 (2016/11/09)
Inhibition of p97 (also known as valosin-containing protein (VCP)), has been validated as a promising strategy for cancer therapy. Eeyarestatin I (EerI) blocks p97 through a novel mechanism of action and has favorable anti-cancer activities against cultured cancer cells. However, its poor aqueous solubility severely limits its in vivo applications. To circumvent this problem, we have identified EerI derivatives that possess improved aqueous solubility by introducing a single solubilizing group. These modified compounds preserved endoplasmic reticulum (ER) stress-inducing and antiproliferative activities as well as generally good in vitro metabolic properties, suggesting that these EerI derivatives could serve as candidates for further optimization.