- QUINOLINYL GLUCAGON RECEPTOR MODULATORS
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The present invention provides a compound of Formula I or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, A1, A2, A3, B1, B2, B3 and B4 are as defined herein. The compounds of Formula I have been found to act as glucagon antagonists or inverse agonists. Consequently, the compounds of Formula I and the pharmaceutical compositions thereof are useful for the treatment of diseases, disorders, or conditions mediated by glucagon.
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Page/Page column 41
(2013/03/26)
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- Effects of oligofluorine substitution on the mutagenicity of quinoline: A study with twelve fluoroquinoline derivatives
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A total of 12 variously fluorinated derivatives of quinoline (Q) were tested for their mutagenicity in Salmonella typhimurium TA100 in the presence of S9 mix to investigate the structure-mutagenicity relationship in oligofluorinated quinolines. Nine of th
- Kato, Taka-Aki,Saeki, Ken-Ichi,Kawazoe, Yutaka,Hakura, Atsushi
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p. 149 - 157
(2007/10/03)
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