226398-48-7

Basic information

• Product Name: 4-(4-Fluoro-phenylsulfanyl)-piperidine-1-carboxylic acid tert-butyl ester
• Synonyms: 4-(4-Fluoro-phenylsulfanyl)-piperidine-1-carboxylic acid tert-butyl ester;tert-Butyl 4-((4-fluorophenyl)thio)piperidine-1-carboxylate
• CAS NO: 226398-48-7
• Molecular Formula: C₁₆H₂₂FNO₂S
• Molecular Weight: 311.4147832
• Mol File: 226398-48-7.mol

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-(4-Fluoro-phenylsulfanyl)-piperidine-1-carboxylic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-Fluoro-phenylsulfanyl)-piperidine-1-carboxylic acid tert-butyl ester(226398-48-7)
• EPA Substance Registry System: 4-(4-Fluoro-phenylsulfanyl)-piperidine-1-carboxylic acid tert-butyl ester(226398-48-7)

Safety Data

• Hazardous Substances Data: 226398-48-7(Hazardous Substances Data)

Upstream product

• 371-42-6 4-Fluorothiophenol 
• 141699-59-4 1-(tert-butoxycarbonyl)piperidin-4-yl methanesulfonate 
• 109384-19-2 t-butyl 4-hydroxy piperidine-1-carboxylate 

Downstream Products

• 226398-50-1 tert-butyl 4-[(4-fluorophenyl)sulfonyl]piperidine-1-carboxylate 
• 333986-37-1 tert-butyl 4-[(4-fluorophenyl)sulfinyl]piperidine-1-carboxylate 
• 105283-71-4 4-[(4-fluorophenyl)sulfonyl]piperidine hydrochloride 
• 105283-71-4 4-((4-fluorophenyl)sulfonyl)piperidine hydrochloride salt 

Relevant articles and documents

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The present invention provides compounds of formula I: which are useful as modulators of GPR6, pharmaceutical compositions thereof, methods for treatment of conditions associated with GPR6, processes for making the compounds and intermediates thereof.

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The present invention provides compounds of formula (I): [Formula should be entered here] which are useful as modulators of GPR6, pharmaceutical compositions thereof, methods for treatment of conditions associated with GPR6, processes for making the compo

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Cyclic amine compounds as CCR5 antagonists

A compound of formula (I) (wherein R1is a hydrogen atom, a hydrocarbon group which may be substituted, a non-aromatic heterocyclic group which may be substituted, R2is a hydrocarbon group which may be substituted, a non-aromatic heterocyclic group which may be substituted, or R1and R2may combine to each other together with A to form a heterocyclic group which may be substituted; A is N or N+—R5.Y?(R5is a hydrocarbon group; Y?is a counter anion); R3is a cyclic hydrocarbon group which may be substituted or a heterocyclic group which may be substituted; n is 0 or 1; R4is a hydrogen atom, a hydrocarbon group which may be substituted, a heterocyclic group which may be substituted, an alkoxy group which may be substituted, an aryloxy group which may be substituted, or an amino group which may be substituted, E is a divalent aliphatic hydrocarbon group which may be substituted by group(s) other than oxo; G1is a bond, CO or SO2; G2is CO, SO2, NHCO, CONH or OCO; J is methine or a nitrogen atom; and each of Q and R is a bond or a divalent C1-3aliphatic hydrocarbon which may be substituted; provided that J is methine when G2is OCO, that one of Q and R is not a bond when the other is a bond and that each of Q and R is not substituted by oxo group(s) when G1is a bond) or a salt thereof has a potent CCR5 antagonistic activity and can be advantageously used for the treatment or prevention of infectious disease of various HIV in human (e.g. AIDS).