105283-71-4

Usage

Uses

Used in Medicinal Chemistry:
4-(4-Fluoro-benzenesulfonyl)-piperidine hydrochloride is used as a building block in the synthesis of pharmaceuticals for its potential to contribute to the development of new drugs. Its unique structure may allow for the creation of compounds with specific therapeutic properties.
Used in Organic Synthesis:
In the realm of organic synthesis, 4-(4-Fluoro-benzenesulfonyl)-piperidine hydrochloride is utilized as a reagent or intermediate. This application is due to its ability to participate in various chemical reactions, facilitating the production of a range of other compounds for different purposes.
Used in Pharmaceutical Research and Development:
4-(4-Fluoro-benzenesulfonyl)-piperidine hydrochloride is employed in pharmaceutical research and development as a potential candidate for drug discovery. Its specific properties and uses are subject to ongoing research and testing to determine its full potential in creating effective and novel therapeutic agents.

Upstream product

• 226398-50-1 tert-butyl 4-[(4-fluorophenyl)sulfonyl]piperidine-1-carboxylate 
• 226398-48-7 tert-butyl 4-[(4-fluorophenyl)sulfanyl]piperidine-1-carboxylate 
• 371-42-6 4-Fluorothiophenol 
• 141699-59-4 1-(tert-butoxycarbonyl)piperidin-4-yl methanesulfonate 
• 109384-19-2 t-butyl 4-hydroxy piperidine-1-carboxylate 

Relevant academic research and scientific papers

TETRAHYDROPYRIDOPYRAZINES MODULATORS OF GPR6

The present invention provides compounds of formula I: which are useful as modulators of GPR6, pharmaceutical compositions thereof, methods for treatment of conditions associated with GPR6, processes for making the compounds and intermediates thereof.

PYRIDOPYRAZINES MODULATORS OF GPR6

The present invention provides compounds of formula (I): [Formula should be entered here] which are useful as modulators of GPR6, pharmaceutical compositions thereof, methods for treatment of conditions associated with GPR6, processes for making the compo

PYRAZINES MODULATORS OF GPR6

The present invention provides compounds of formula (I): which are useful as modulators of GPR6, pharmaceutical compositions thereof, methods for treatment of conditions associated with GPR6, processes for making the compounds and intermediates thereof.

SOLUBLE EPOXIDE HYDROLASE INHIBITORS AND METHODS OF USING SAME

Disclosed are compounds active against soluble epoxide hydrolase (sEH), compositions thereof and methods of using and making same.

Discovery of a piperidine-4-carboxamide CCR5 antagonist (TAK-220) with highly potent anti-HIV-1 activity

We incorporated various polar groups into previously described piperidine-4-carboxamide CCR5 antagonists to improve their metabolic stability in human hepatic microsomes. Introducing a carbamoyl group into the phenyl ring of the 4-benzylpiperidine moiety

Cyclic amine compounds as CCR5 antagonists

A compound of formula (I) (wherein R1is a hydrogen atom, a hydrocarbon group which may be substituted, a non-aromatic heterocyclic group which may be substituted, R2is a hydrocarbon group which may be substituted, a non-aromatic heterocyclic group which may be substituted, or R1and R2may combine to each other together with A to form a heterocyclic group which may be substituted; A is N or N+—R5.Y?(R5is a hydrocarbon group; Y?is a counter anion); R3is a cyclic hydrocarbon group which may be substituted or a heterocyclic group which may be substituted; n is 0 or 1; R4is a hydrogen atom, a hydrocarbon group which may be substituted, a heterocyclic group which may be substituted, an alkoxy group which may be substituted, an aryloxy group which may be substituted, or an amino group which may be substituted, E is a divalent aliphatic hydrocarbon group which may be substituted by group(s) other than oxo; G1is a bond, CO or SO2; G2is CO, SO2, NHCO, CONH or OCO; J is methine or a nitrogen atom; and each of Q and R is a bond or a divalent C1-3aliphatic hydrocarbon which may be substituted; provided that J is methine when G2is OCO, that one of Q and R is not a bond when the other is a bond and that each of Q and R is not substituted by oxo group(s) when G1is a bond) or a salt thereof has a potent CCR5 antagonistic activity and can be advantageously used for the treatment or prevention of infectious disease of various HIV in human (e.g. AIDS).