235425-06-6Relevant articles and documents
Synthesis of novel 4(5)-(5-aminotetrahydropyran-2-yl)imidazole derivatives and their in vivo release of neuronal histamine measured by brain microdialysis
Harusawa, Shinya,Kawamura, Makoto,Araki, Lisa,Taniguchi, Ryusuke,Yoneyama, Hiroki,Sakamoto, Yasuhiko,Kaneko, Noritsugu,Nakao, Yumi,Hatano, Kouta,Fujita, Takeshi,Yamamoto, Ryoko,Kurihara, Takushi,Yamatodani, Atsushi
, p. 1245 - 1253 (2007)
The (2R,5S)-trans- and (2S,5S)-cis-stereoisomers 1a and 1b of 4(5)-(5-aminotetrahydropyran-2-yl)imidazole, which have two chiral centers and adopt a stable chair conformation, were synthesized via cyclization of diol intermediates 7 using L-glutamine as t
Chemo- and regioselective syntheses of enantiopure aminopyrrolidinones as building blocks for constrained peptidomimetics
Lehmann, Thomas,Michel, Dorothee,Glaenzel, Markus,Waibel, Reiner,Gmeiner, Peter
, p. 1389 - 1400 (2007/10/03)
Starting from natural asparagine the synthesis of the N-protected enantiomerically pure 3- and 4-aminopyrrolidinones (1) and (3) was accomplished. The incorporation of these building blocks into conformationally constrained peptidomimetics was demonstrated by the synthesis of the potential dopamine receptor modulator (14b) (β-PAOPA). Furthermore, Freidinger γ-lactams including the protected dipeptide mimetics (8a-c) and (9) were prepared. The optical integrity of the synthesis was established by NMR analysis of the ureas (10a,b).
