- Selective catalytic behavior of a phosphine-tagged metal-organic framework organocatalyst
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Steric hindrance by a metal-organic framework (MOF) is shown to influence the outcome of a catalytic reaction by controlling the orientation of its intermediates. This is demonstrated using an organocatalyst, phosphine MOF LSK-3, which is evaluated with t
- Xu, Xiaoying,Rummelt, Stephan M.,Morel, Flavien L.,Ranocchiari, Marco,Van Bokhoven, Jeroen A.
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supporting information
p. 15467 - 15472
(2016/02/18)
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- Synthesis of functionalized benzo[b]thiophenes by the intramolecular copper-catalyzed carbomagnesiation of alkynyl(aryl)thioethers
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Highly functional: A copper(I)-catalyzed intramolecular carbomagnesiation under mild conditions transforms readily available alkynyl(aryl)thioethers into magnesiated benzothiophenes. Subsequent reaction with various electrophiles (acid chlorides, allyl bromides, aryl halides) provides polyfunctional benzo[b]thiophenes (see scheme). Further modification of the cyclization products affords highly diversified benzothiophene derivatives and new heterocyclic scaffolds.
- Kunz, Thomas,Knochel, Paul
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p. 1958 - 1961
(2012/04/18)
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- BIS-(SULFONYLAMINO) DERIVATIVES IN THERAPY 065
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The invention provides compounds of formula wherein R1, R2, R3, A and m are as defined in the specification and optical isomers, racemates and tautomers thereof, and pharmaceutically acceptable salts thereof; together with processes for their preparation, pharmaceutical compositions containing them and their use in therapy. The compounds are inhibitors of microsomal prostaglandin E synthase-1
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Page/Page column 73
(2009/05/28)
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- BIS-(SULFONYLAMINO) DERIVATIVES IN THERAPY 066
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The invention provides compounds of formula wherein R1, R3, L1, L2, G1, G2, A and m are as defined in the specification and optical isomers, racemates and tautomers thereof, and pharmaceutically acceptable salts thereof; together with processes for their preparation, pharmaceutical compositions containing them and their use in therapy. The compounds are inhibitors of microsomal prostaglandin E synthase-1.
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Page/Page column 157
(2009/06/27)
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- Discovery of potent and selective SH2 inhibitors of the tyrosine kinase ZAP-70
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A series of 1,2,4-oxadiazole analogues has been shown to be potent and selective SH2 inhibitors of the tyrosine kinase ZAP-70, a potential therapeutic target for immune suppression. These compounds typically are 200- 400-fold more potent than the native,
- Vu, Chi B.,Corpuz, Evelyn G.,Merry, Taylor J.,Pradeepan, Selvaluxmi G.,Bartlett, Catherine,Bohacek, Regine S.,Botfield, Martyn C.,Eyermann, Charles J.,Lynch, Berkley A.,MacNeil, Ian A.,Ram, Mary K.,Van Schravendijk, Marie Rose,Violette, Shelia,Sawyer, Tomi K.
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p. 4088 - 4098
(2007/10/03)
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