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tert-Butyl 4-(4-amino-2-fluorophenoxy)piperidine-1-carboxylate is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 250372-00-0 Structure
  • Basic information

    1. Product Name: tert-Butyl 4-(4-amino-2-fluorophenoxy)piperidine-1-carboxylate
    2. Synonyms: tert-Butyl 4-(4-amino-2-fluorophenoxy)piperidine-1-carboxylate
    3. CAS NO:250372-00-0
    4. Molecular Formula: C16H23FN2O3
    5. Molecular Weight: 310.3638232
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 250372-00-0.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 439.1±45.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.190±0.06 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. PKA: 4.09±0.10(Predicted)
    10. CAS DataBase Reference: tert-Butyl 4-(4-amino-2-fluorophenoxy)piperidine-1-carboxylate(CAS DataBase Reference)
    11. NIST Chemistry Reference: tert-Butyl 4-(4-amino-2-fluorophenoxy)piperidine-1-carboxylate(250372-00-0)
    12. EPA Substance Registry System: tert-Butyl 4-(4-amino-2-fluorophenoxy)piperidine-1-carboxylate(250372-00-0)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 250372-00-0(Hazardous Substances Data)

250372-00-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 250372-00-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,5,0,3,7 and 2 respectively; the second part has 2 digits, 0 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 250372-00:
(8*2)+(7*5)+(6*0)+(5*3)+(4*7)+(3*2)+(2*0)+(1*0)=100
100 % 10 = 0
So 250372-00-0 is a valid CAS Registry Number.

250372-00-0Relevant articles and documents

Cinnamyl derivatives: Synthesis and factor Xa (FXa) inhibitory activities

Noguchi, Tetsuji,Tanaka, Naoki,Nishimata, Toyoki,Goto, Riki,Hayakawa, Miho,Sugidachi, Atsuhiro,Ogawa, Taketoshi,Asai, Fumitoshi,Fujimoto, Koichi

experimental part, p. 758 - 770 (2009/05/31)

To develop a potent and oral anticoagulant, a series of compounds with cinnamyl moiety was synthesized and their factor Xa (FXa) inhibitory activities were examined. As a result, some cinnamyl derivatives showed potent FXa inhibitory activities in vitro. Among them, compounds with substituent at the 3-position on the central benzene ring represented by (N-{4-[1-(acetimidoyl) piperidin-4-yloxy]-3-chlorophenyl}-N-[(E)-3-(3-amidinophenyl)-2-propenyl] sulfamoyl)acetic acid dihydrochloride (45b) and (N-{4-[1-(acetimidoyl)piperidin- 4-yloxy]-3-carbamoylphenyl}-N-[(E)-3-(3-amidinophenyl)-2-propenyl]sulfamoyl) acetic acid dihydrochloride (45j) exhibited potent FXa inhibitory activities with IC50 values of less than 10 nM in vitro. These compounds also showed potent anticoagulant activities both in vitro and ex vivo. Furthermore, these compounds exhibited no lethal toxicity (30 mg/kg, i.v.).

N-(3,4-disubstituted phenyl) salicylamide derivatives

-

Page/Page column 45, (2008/12/07)

A compound represented by the following formula (I) or a salt thereof: wherein R1, R2, R3 and R4 represent hydrogen atom, a halogen atom, cyano group, nitro group, a C1-4 alkyl group, a halogenated C

BENZAMIDINE DERIVATIVES

-

, (2008/06/13)

Benzamidine derivatives of formula (I) or pharmaceutically acceptable salts thereof exhibit excellent inhibitory activity against factor Xa and are useful for treating or preventing blood coagulation disorders: wherein R 1represents a hydrogen atom, a halogen atom, an alkyl group or a hydroxyl group; R 2represents a hydrogen atom, a halogen atom or an alkyl group, R 3represents a hydrogen atom, an optionally substituted alkyl group, an aralkyl group, an optionally substituted alkanoyl group or an optionally substituted alkylsulfonyl group, R 4and R 5 are the same as or different from each other and each represent a hydrogen atom, a halogen atom, an optionally substituted alkyl group, an alkoxy group, a carboxyl group, an alkoxycarbonyl group or an optionally substituted carbamoyl group, and R 6represents a substituted pyrrolidine group or substituted piperidine group.

Novel piperidinyloxy oxazolidinone antibacterial agents. Diversification of the N-substituent

Weidner-Wells, Michele A.,Boggs, Christine M.,Foleno, Barbara D.,Melton, John,Bush, Karen,Goldschmidt, Raul M.,Hlasta, Dennis J.

, p. 2345 - 2351 (2007/10/03)

Oxazolidinone antibacterial agents, where the morpholino group of linezolid was replaced with an N-substituted piperidinyloxy moiety, were synthesized and shown to be active against a variety of resistant and susceptible Gram-positive organisms. The funct

Design and synthesis of aminophenol-based factor Xa inhibitors

Wu, Shung,Guilford, William J,Chou, Yuo-Ling,Griedel, Brian D,Liang, Amy,Sakata, Steve,Shaw, Kenneth J.,Trinh, Lan,Xu, Wei,Zhao, Zuchun,Morrissey, Michael M.

, p. 1307 - 1310 (2007/10/03)

A novel potent and selective aminophenol scaffold for fXa inhibitors was developed from a previously reported benzimidazole-based naphthylamidine template. The aminophenol template is more synthetically accessible than the benzimidazole template, which si

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