250592-89-3

Upstream product

• 250592-88-2 3-((2-methyl)-6-nitrophenyl)-4,5-dihydroisoxazole 
• 83-41-0 2,3-dimethylnitrobenzene 

Downstream Products

• 250592-91-7 3-((2-methyl)-6-methylthiophenyl)-4,5-dihydroisoxazole 
• 210631-68-8 topramezone 
• 223646-24-0 3-(4,5-dihydroisoxazol-3-yl)-4-methylsulfonyl-2-methylbenzoic acid 
• 75-65-0 tert-butyl alcohol 
• 250592-93-9 4-bromo-2-(4,5-dihydroisoxazol-3-yl)-3-methylaniline 
• 388078-54-4 6-bromo-2-(4,5-dihydroisoxazol-3-yl)-3-methylaniline 
• 388078-53-3 4,6-dibromo-2-(4,5-dihydroisoxazol-3-yl)-3-methylaniline 

Relevant academic research and scientific papers

Improved method for preparing topramezone

The invention discloses an improved method for preparing topramezone and belongs to the technical field of chemical synthesis. The improved method takes 3-nitro-o-xylene as a raw material and is characterized in that the topramezone is obtained through oximation reaction, ethylene cyclization, palladium carbon reduction, diazotization, aldehydelation, oxidation and condensation rearrangement reaction; under optimal conditions, the total yield is 33.7 percent, the raw material is cheap and easy to obtain, the treatment is convenient in the whole process, the yield is relatively high, and a certain significance in industrialized production is realized.

Method and novel intermediate products for producing isoxazolin-3-yl-acylbenzenenes

The present invention describes a process for preparing isoxazoles of the formula I where: R1is hydrogen, C1-C6-alkyl, R2is hydrogen, C1-C6-alkyl, R3, R4, R5are each hydrogen, C1-C6-alkyl or R4and R5together from a bond, R6is a heterocysclic ring, n is 0, 1 or 2; which comprises preparing an intermediate of the formula VI where R1, R3, R4and R5are each as defined above, followed by halogenation, thiomethylation, oxidation and acylation to give compounds of the formula I. Furthermore, the invention describes novel intermediates for preparing the compounds of the formula I and novel processes for preparing the intermediates.