252669-21-9

Basic information

• Product Name: 2-(3-chlorophenyl)-N-methoxy-N-methylacetamide
• Synonyms: 2-(3-chlorophenyl)-N-methoxy-N-methylacetamide
• CAS NO: 252669-21-9
• Molecular Formula: C₁₀H₁₂ClNO₂
• Molecular Weight: 213.66078
• Mol File: 252669-21-9.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(3-chlorophenyl)-N-methoxy-N-methylacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3-chlorophenyl)-N-methoxy-N-methylacetamide(252669-21-9)
• EPA Substance Registry System: 2-(3-chlorophenyl)-N-methoxy-N-methylacetamide(252669-21-9)

Safety Data

• Hazardous Substances Data: 252669-21-9(Hazardous Substances Data)

Upstream product

• 1878-65-5 3-chlorophenylacetic acid 
• 6638-79-5 N,O-dimethylhydroxylamine*hydrochloride 
• 221121-26-2 2-(3-chloro-phenyl)-1-imidazol-1-yl-ethanone 
• 1117-97-1 N,0-dimethylhydroxylamine 

Downstream Products

• 346672-52-4 [3-(3-chloro-phenyl)-2-oxo-propyl]-phosphonic acid dimethyl ester 
• 494224-35-0 C₂₁H₂₈ClNO₄S 
• 494221-70-4 7-{(2R)-2-[(1E,3S)-3-hydroxy-4-(3-chlorophenyl)-1-buten-1-yl]-5-oxo-1-pyrrolidinyl}heptanoic acid 
• 533893-55-9 ethyl 7-[(2R)-2-{(1E,3S)-3-hydroxy-4-(3-chlorophenyl)-1-buten-1-yl}-5-oxo-1-pyrrolidinyl]heptanoate 
• 533893-65-1 C₂₃H₃₀ClNO₄ 
• 1000771-11-8 C₁₀H₉ClO 

Relevant articles and documents

Enantioselective Addition of Alkynyl Ketones to Nitroolefins Assisted by Br?nsted Base/H-Bonding Catalysis

Various sets of enolizable alkynyl ketones (including methyl ynones with α-aryl, α-alkenyl, and α-alkoxy groups) were able to react smoothly with nitroolefins with the assistance of bifunctional Br?nsted base/H-bond catalysts to provide adducts with two consecutive tertiary stereocenters in a highly diastereo- and enantioselective fashion. Further transformation of the obtained adducts into optically active acyclic and polycyclic molecules, including some with intricate carbon skeletons, was also demonstrated.

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Chiral-at-metal RhIII complexes catalyze the efficient enantioselective Mannich reaction of 2-acyl imidazoles with 1,3,5-triazinanes, affording the corresponding adducts in 81–99 % yield with up to >99 % enantioselectivity. This protocol performs with 0.1 mol-% of RhIII complex on gram scale without any loss in enantioselectivity.

An Environmentally Sustainable Mechanochemical Route to Hydroxamic Acid Derivatives

An operationally simple, and cost efficient conversion of carboxylic acids into hydroxamic acid derivatives via a high-energy mechanochemical activation is presented. This ball milling methodology was applied to a wide variety of carboxylic acids dramatically improving purification issues associated with this class of molecules, which still remain one of the main bottlenecks of classical methodologies. (Figure presented.).

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