253-69-0 Usage
Uses
Used in Pharmaceutical Industry:
1,7-Naphthyridine(6CI,7CI,8CI,9CI) is used as a building block for the synthesis of pharmaceutical compounds due to its unique molecular structure and potential biological activities, including anti-inflammatory and antitumor properties. Its incorporation into drug molecules can enhance their therapeutic effects and target specific biological pathways.
Used in Agrochemical Industry:
In the agrochemical industry, 1,7-Naphthyridine(6CI,7CI,8CI,9CI) serves as a key intermediate in the synthesis of various agrochemicals. Its chemical properties allow for the development of compounds that can effectively control pests and diseases in agriculture, contributing to increased crop yields and food security.
Used in Dye Industry:
1,7-Naphthyridine(6CI,7CI,8CI,9CI) is used as an intermediate in the production of dyes, particularly those with specific color characteristics and properties. Its unique molecular structure enables the creation of dyes with improved stability, colorfastness, and application versatility in various industries such as textiles, plastics, and printing.
Used in Organic Compounds Synthesis:
As a versatile intermediate, 1,7-Naphthyridine(6CI,7CI,8CI,9CI) is employed in the synthesis of a wide range of organic compounds. Its reactivity and structural features make it a valuable component in the development of new materials and compounds with diverse applications in various industries, including chemical, pharmaceutical, and materials science.
Used in Chemical Research:
1,7-Naphthyridine(6CI,7CI,8CI,9CI) is extensively used in chemical research to explore its potential applications and properties. Researchers investigate its reactivity, stability, and interactions with other molecules to gain insights into its potential uses and to develop new synthetic methods and applications.
Check Digit Verification of cas no
The CAS Registry Mumber 253-69-0 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 2,5 and 3 respectively; the second part has 2 digits, 6 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 253-69:
(5*2)+(4*5)+(3*3)+(2*6)+(1*9)=60
60 % 10 = 0
So 253-69-0 is a valid CAS Registry Number.
InChI:InChI=1/C8H6N2/c1-2-7-3-5-9-6-8(7)10-4-1/h1-6H
253-69-0Relevant articles and documents
Optimization of potency and pharmacokinetic properties of tetrahydroisoquinoline transient receptor potential melastatin 8 (TRPM8) antagonists
Horne, Daniel B.,Tamayo, Nuria A.,Bartberger, Michael D.,Bo, Yunxin,Clarine, Jeffrey,Davis, Carl D.,Gore, Vijay K.,Kaller, Matthew R.,Lehto, Sonya G.,Ma, Vu V.,Nishimura, Nobuko,Nguyen, Thomas T.,Tang, Phi,Wang, Weiya,Youngblood, Beth D.,Zhang, Maosheng,Gavva, Narender R.,Monenschein, Holger,Norman, Mark H.
, p. 2989 - 3004 (2014/05/06)
Transient receptor potential melastatin 8 (TRPM8) is a nonselective cation channel expressed in a subpopulation of sensory neurons in the peripheral nervous system. TRPM8 is the predominant mammalian cold temperature thermosensor and is activated by cold temperatures ranging from 8 to 25 °C and cooling compounds such as menthol or icilin. TRPM8 antagonists are being pursued as potential therapeutics for treatment of pain and bladder disorders. This manuscript outlines new developments in the SAR of a lead series of 1,2,3,4-tetrahydroisoquinoline derivatives with emphasis on strategies to improve pharmacokinetic properties and potency. Selected compounds were profiled in two TRPM8 target-specific in vivo coverage models in rats (the icilin-induced wet dog shake model and the cold pressor test). Compound 45 demonstrated robust efficacy in both pharmacodynamic models with ED90 values 3 mg/kg.
A New Approach to the Preparation of 1,6- and 1,7-Naphthyridines
Giam, C. S.,Ambrozich, Deborah
, p. 265 - 266 (2007/10/02)
Substituted 1,6- and 1,7-naphthyridines can be prepared by a simple route from readily available pyrindane; this method is more flexible and produces higher yields than previous routes.
