90685-59-9

Basic information

• Product Name: 6,7-Dihydro-5H-cyclopenta[b]pyridin-7-yl Acetate
• Synonyms: 6,7-Dihydro-5H-cyclopenta[b]pyridin-7-yl Acetate;5H-1-Pyrindin-7-ol, 6,7-dihydro-, acetate
• CAS NO: 90685-59-9
• Molecular Formula: C₁₀H₁₁NO₂
• Molecular Weight: 177.19984
• EINECS: -0
• Mol File: 90685-59-9.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 6,7-Dihydro-5H-cyclopenta[b]pyridin-7-yl Acetate(CAS DataBase Reference)
• NIST Chemistry Reference: 6,7-Dihydro-5H-cyclopenta[b]pyridin-7-yl Acetate(90685-59-9)
• EPA Substance Registry System: 6,7-Dihydro-5H-cyclopenta[b]pyridin-7-yl Acetate(90685-59-9)

Safety Data

• Hazardous Substances Data: 90685-59-9(Hazardous Substances Data)

Usage

General Description

The chemical 6,7-Dihydro-5H-cyclopenta[b]pyridin-7-yl Acetate is an organic compound with the molecular formula C12H13NO2. It is a derivative of cyclopenta[b]pyridine and consists of a cyclopentane ring fused with a pyridine ring. The compound is an acetate ester, meaning it contains an acetate group, which is a functional group consisting of a methyl group attached to a carbonyl carbon. This chemical may have pharmaceutical applications as it is part of the chemical structure of certain drugs, and it may also have industrial uses as a precursor or intermediate in chemical synthesis.

Upstream product

• 90685-58-8 6,7-dihydro-5H-cyclopenta[b]pyridine 1-oxide 
• 108-24-7 acetic anhydride 
• 533-37-9 2,3-cyclopentenopyridine 
• 64-19-7 acetic acid 
• 56946-65-7 2,4-dichloro-6,7-dihydro-5H-cyclopenta[b]pyridine 

Downstream Products

• 270-91-7 5H-1-pyrindine 
• 270-92-8 7H-cyclopenta[b]pyridine 
• 253-69-0 [1,7]naphthyridine 
• 253-72-5 1,6-naphthyridine 
• 1333210-37-9 (1aR,6aS)-6,6a-dihydro-1aH-oxireno[4,5]cyclopenta[1,2-b]pyridine 
• 1333210-27-7 4-({(5R,6R)-6-[(3R)-3-aminopiperidin-1-yl]-6, 7-dihydro-5H-cyclopenta[b]pyridin-5-yl}oxy)-3-chlorobenzonitrile 
• 1333210-28-8 4-({(6R,7S)-6-[(3R)-3-aminopiperidin-1-yl]-6,7-dihydro-5H-cyclopenta[b]pyridin-7-yl}oxy)-3-chlorobenzonitrile 
• 1333210-38-0 (1aS,6aR) 2,6b-dihydro-1aH-oxireno[3,4]cyclopenta[1,2-b]pyridine 
• 1356401-48-3 C₂₅H₂₉ClN₄O₃ 
• 912277-45-3 (R)-5H,6H,7H-cyclopenta[b]pyridin-7-ol 

Relevant articles and documents

SMALL MOLECULE INHIBITORS OF NF-kB INDUCING KINASE

The present invention relates to compounds that inhibit NIK and pharmaceutical compositions comprising such compounds and methods of using the same. These compounds and pharmaceutical compositions are envisaged to be useful for preventing or treating diseases such as cancer (such as B-cell malignancies including leukemias, lymphomas and myeloma), inflammatory disorders, autoimmune disorders, immunodermatologic disorders such as palmoplantar pustulosis and hidradenitis suppurativa, and metabolic disorders such as obesity and diabetes.

Enantiopure synthesis of 7-(1-pyrindanyl)propargyl ethers as rasagiline analogues via chemical or enzymatic resolution of 1-pyrindan-7-ol

In this work, the enantiopure synthesis of 7-(1-pyrindanyl)propargyl ethers - rasagiline analogues - via chemical and/or enzymatic resolution of the racemic precursor 1-pyrindan-7-ol is described. (R)-Methoxyphenylacetic acid - (R)-MPAA - and (S)-methoxyphenylacetic acid - (S)-MPAA were used as chemical resolution agents, whereas Candida antarctica lipase B (CALB) was employed as kinetic resolution catalyst. The enzymatic resolution was successfully achieved by two different approaches: (1) transesterification of racemic 1-pyrindan-7-ol, which was found to selectively acylate the (R)-enantiomer with high efficiency; (2) hydrolysis of the racemic 7-(1-pyrindanyl)acetate, which was also highly selective to the (R)-enantiomer. The enzymatic hydrolysis was performed in a non-aqueous solvent using a lipase with significant absorbed water content. The configuration of the two enantiomers of 1-pyrindan-7-ol (and consequently of the 7-(1-pyrindanyl)propargyl ethers) were unequivocally determined by X-ray crystallography and/or specific optical rotation.

Synthesis of New Propargylated 1-Pyrindane Derivatives as Rasagiline Analogues

Rasagiline is a compound with important neuroprotective activity applicable to the treatment of neurodegenerative diseases. This work describes an easy and straightforward methodology to the synthesis of new propargylated rasagiline analogues derived from commercially available 6,7-dihydro-5H-cyclopenta[b] pyridine. Georg Thieme Verlag Stuttgart - New York.