25343-52-6

Basic information

• Product Name: Phenylimino(amino)methanesulfonic acid
• Synonyms: Anilino(imino)methanesulfonic acid;Imino(phenylamino)methanesulfonic acid;N-Phenylformamidinosulfonic acid;Phenylimino(amino)methanesulfonic acid
• CAS NO: 25343-52-6
• Molecular Formula: C₇H₈N₂O₃S
• Molecular Weight: 200.21
• Mol File: 25343-52-6.mol

Chemical Properties

• Melting Point: 157.5-158.5 °C
• Appearance: /
• Density: 1.47g/cm³
• Refractive Index: 1.622
• PKA: -10.89±0.30(Predicted)
• CAS DataBase Reference: Phenylimino(amino)methanesulfonic acid(CAS DataBase Reference)
• NIST Chemistry Reference: Phenylimino(amino)methanesulfonic acid(25343-52-6)
• EPA Substance Registry System: Phenylimino(amino)methanesulfonic acid(25343-52-6)

Safety Data

• Hazardous Substances Data: 25343-52-6(Hazardous Substances Data)

Usage

InChI:InChI=1/C7H8N2O3S/c8-7(13(10,11)12)9-6-4-2-1-3-5-6/h1-5H,(H2,8,9)(H,10,11,12)

Upstream product

• 103-85-5 monophenylthiourea 
• 2227-79-4 benzenecarbothioamide 

Downstream Products

• 41410-39-3 N-phenyl-N'-cyanoguanidine 
• 127866-73-3 2-amino-2-phenyliminoethanenitrile 
• 5467-78-7 fenamole 
• 65071-09-2 N-phenyltetrahydro-1H-pyrrole-1-carboximidamide 
• 75358-18-8 N-phenyl-(tetrahydro-4H-1,4-oxazine)-4-carboximidamide 
• 13636-30-1 N-sec-Butyl-N'-phenyl-guanidine 
• 13636-29-8 N-Isobutyl-N'-phenyl-guanidine 
• 101010-25-7 N-Cyclohexyl-N'-phenyl-guanidine 
• 13636-36-7 N-(4-Chloro-phenyl)-N'-phenyl-guanidine 
• 101010-23-5 N-(4-Methoxy-phenyl)-N'-phenyl-guanidine 
• 108787-57-1 4-(N'-Phenyl-guanidino)-benzoic acid 
• 101010-27-9 N-(4-Nitro-phenyl)-N'-phenyl-guanidine 
• 17813-43-3 N-tert-Butyl-N'-phenyl-guanidine 
• 102-06-7 diphenylguanidine 

Relevant articles and documents

Nitric oxide donor micromolecule, and preparation method and application thereof

The invention discloses a donor micromolecule, and a preparation method and application thereof. The donor micromolecule contains a nitroreductase trigger group and a novel nitric oxide donor (N-hydroxyguanidine), and has the advantages of simple synthesis process and efficient and rapid application. The donor micromolecule can release high-concentration nitric oxide under trigger of over-expressed nitroreductase in mitochondria of tumor cells to kill cancer cells. The nitric oxide donor introduced into the small molecule is applied to biological research for the first time, and the inventionprovides a new tool for developing a new nitric oxide release system and inhibiting activity of tumor cells.

A new class of NO-donor pro-drugs triggered by γ-glutamyl transpeptidase with potential for reno-selective vasodilatation

This communication describes the synthesis of a new class of N-hydroxyguanidine (NHG) pro-drugs which release nitric oxide (NO), triggered by the action of γ-glutamyl transpeptidase (γ-GT), and have potential for the treatment of acute renal injury/failur

Efficient synthesis of 2-arylamino-2-imidazolines and 2-aminobenzimidazoles with aminoiminomethanesulfonic acid derivatives

A highly efficient synthesis of 2-arylamino-2-imidazolines and 2-aminobenzimidazoles from aminoiminomethanesulfonic acid derivatives is described. The method is simple and practical, generating imidazoline and benzimidazoline derivatives in excellent isolated yields.

A Facile Conversion of Amino Acids to Guanidino Acids

The conversion of amino acids to guanidino acids by the action of aminoiminomethanesulfonic acids (2a-c) is reported.Compounds 2a-c were synthesized by peracetic acid oxidation of the corresponding thioureas.

REACTIONS OF OXIDIZED THIOUREAS WITH AMINE NUCLEOPHILES

A route for the convenient, cost effective synthesis of di- and tri-substituted guanidines from thioureas has been developed.The key transformation involves activation of the sulfur through S-oxidation followed by displacement of the activated sulfur by a