41410-39-3Relevant articles and documents
Preparation method of triazine compound
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Paragraph 0007; 0025-0026, (2021/07/24)
The invention provides a preparation method of a 4-methyl-6-anilino 2-sulfydryl-1, 3, 5-triazine compound as shown in a formula (I) in the specification. The method comprises the following steps: adding sodium into methanol, adding a phenyl amidino thiour
Repurposing N,N'-bis-(arylamidino)-1,4-piperazinedicarboxamidines: An unexpected class of potent inhibitors of cholinesterases
Loesche, Anne,Wiese, Jana,Sommerwerk, Sven,Simon, Vivienne,Brandt, Wolfgang,Csuk, René
supporting information, p. 430 - 434 (2016/10/04)
Drug repurposing (=drug repositioning) is an effective way to cut costs for the development of new therapeutics and to reduce the time-to-market time-span. Following this concept a small library of compounds was screened for their ability to act as inhibitors of acetyl- and butyrylcholinesterase. Picloxydine, an established antiseptic, was shown to be an inhibitor for both enzymes. Systematic variation of the aryl substituents led to analogs possessing almost the same good properties as gold standard galantamine hydrobromide.
The Synthesis of Aminoiminoethanenitriles, 5-Aminotetrazoles, N-Cyanoguanidines, and N-Hydroxyguanidines from Aminoiminomethanesulfonic Acids
Miller, Audrey E.,Feeney, Daniel J.,Ma, Yan,Zarcone, Lyn,Aziz, M. A.,Magnuson, E.
, p. 217 - 226 (2007/10/02)
Examples of the reactions of aminoiminomethanesulfonic acids with cyanide, azide, cyanamide and hydroxylamine as nucleophiles are reported.