2540-99-0

Basic information

• Product Name: 3,3',4,4'-DIPHENYLSULFONETETRACARBOXYLIC DIANHYDRIDE
• Synonyms: 3,3',4,4'-DIPHENYLSULFONETETRACARBOXYLIC DIANHYDRIDE;4,4'-SULFONYLDIPHTHALIC ANHYDRIDE;DSDA;4,4'-Sulfonyldiphthalic dianhydride;diphenylsulfonetetracarboxylicdianhydride;3,3,4,4''-DIPHENYLSULFONETETRACARBOXYLIC DIANHYDRIDE 96+%;4,4'-Sulfonylbis(benzene-1,2-dicarboxylic acid)1,2:1',2'-dianhydride;4,4'-Sulfonylbisphthalic 1,2:1',2'-dianhydride
• CAS NO: 2540-99-0
• Molecular Formula: C₁₆H₆O₈S
• Molecular Weight: 358.28
• Product Categories: Aromatic Tetracarboxylic Dianhydrides (for High-Performance Polymer Research);Diphenyl Sulfones (for High-Performance Polymer Research);Functional Materials;Reagent for High-Performance Polymer Research
• Mol File: 2540-99-0.mol

Chemical Properties

• Melting Point: 283 °C
• Boiling Point: 718.549 °C at 760 mmHg
• Flash Point: 388.364 °C
• Appearance: /
• Density: 1.756 g/cm³
• Vapor Pressure: 1.69E-20mmHg at 25°C
• Refractive Index: 1.697
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: 3,3',4,4'-DIPHENYLSULFONETETRACARBOXYLIC DIANHYDRIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3,3',4,4'-DIPHENYLSULFONETETRACARBOXYLIC DIANHYDRIDE(2540-99-0)
• EPA Substance Registry System: 3,3',4,4'-DIPHENYLSULFONETETRACARBOXYLIC DIANHYDRIDE(2540-99-0)

Safety Data

• Hazardous Substances Data: 2540-99-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
3,3',4,4'-Diphenylsulfonetetracarboxylic dianhydride is used as a novel class of human immunodeficiency virus type 1 (HIV-1) integrase inhibitors. It plays a crucial role in the development of new antiviral therapies by inhibiting the integrase enzyme, which is essential for the replication of the virus in host cells. This inhibition helps to prevent the integration of the viral DNA into the host genome, thus suppressing the viral replication process and providing a potential treatment option for HIV-1 infection.

InChI:InChI=1/C16H6O8S/c17-13-9-3-1-7(5-11(9)15(19)23-13)25(21,22)8-2-4-10-12(6-8)16(20)24-14(10)18/h1-6H

Synthetic route

3,3’,4,4’-diphenylsulfonetetracarboxylic acid (10595-31-0) → 3,3',4,4'-diphenylsulfonetetracarboxylic acid dianhydride (2540-99-0)

Conditions	Yield
With 2,6-bis[(2,2,6,6-tetramethylpiperidin-1-yl)methyl]phenylboronic acid In propyl cyanide for 12h; Reflux;	92%

3,3′,4,4′-diphenylsulfidetetracarboxylic dianhydride (25884-43-9) → 3,3',4,4'-diphenylsulfonetetracarboxylic acid dianhydride (2540-99-0)

Conditions	Yield
With dipotassium peroxodisulfate; ammonium cerium (IV) nitrate; tetra-(n-butyl)ammonium iodide In water; acetonitrile at 60℃; Temperature; Solvent; Reagent/catalyst;

3,3',4,4'-diphenylsulfonetetracarboxylic acid dianhydride (2540-99-0) + 1-amino-2-propene (107-11-9) → C22H16N2O6S

Conditions	Yield
With acetic acid at 20℃; for 9h; Inert atmosphere; Reflux;	92%

3,3',4,4'-diphenylsulfonetetracarboxylic acid dianhydride (2540-99-0) + LEUCINE (328-39-2) → C28H28N2O10S

Conditions	Yield
With acetic acid at 120℃;	90%

aluminum(III) nitrate nonahydrate + 3,3',4,4'-diphenylsulfonetetracarboxylic acid dianhydride (2540-99-0) → [Al2(OH)2(DPSTC)(H2O)2]·0.5H2O

Conditions	Yield
With sodium hydroxide In water at 170℃; for 5h; Microwave irradiation;	85%

3,3',4,4'-diphenylsulfonetetracarboxylic acid dianhydride (2540-99-0) + (R)-leucine (328-38-1) → C28H28N2O10S

Conditions	Yield
With acetic acid at 120℃; for 0.166667h; Microwave irradiation;	79%

3,3',4,4'-diphenylsulfonetetracarboxylic acid dianhydride (2540-99-0) + gallium(III) nitrate heptahydrate + water (7732-18-5) → Ga-CAU-11-COOH

Conditions	Yield
With acetic acid; sodium hydroxide at 180℃; for 24h; Autoclave;	77%

3,3',4,4'-diphenylsulfonetetracarboxylic acid dianhydride (2540-99-0) + L-leucine (61-90-5) → C28H28N2O10S

Conditions	Yield
With acetic acid at 120℃; for 0.166667h; Microwave irradiation;	72%

3,3',4,4'-diphenylsulfonetetracarboxylic acid dianhydride (2540-99-0) + recorcinol (108-46-3) → 2-(3,6,9-trihydroxyxanthen-9-yl)-5-(3,4-dicarboxyphenylsulfonyl)benzoic acid lactone

Conditions	Yield
at 180℃; for 6h;	66.5%

3,3',4,4'-diphenylsulfonetetracarboxylic acid dianhydride (2540-99-0) → 3,3’,4,4’-diphenylsulfonetetracarboxylic acid (10595-31-0)

Conditions	Yield
With water Hydrolysis; Heating;	65%

4,4'-bipyridine (553-26-4) + 3,3',4,4'-diphenylsulfonetetracarboxylic acid dianhydride (2540-99-0) + water (7732-18-5) + silver nitrate → [Ag(4,4'-bipyridine)]2*3,3',4,4'-tetracarboxydiphenylsulfone(2-)*2water

Conditions	Yield
In water High Pressure; heating a mixt. of silver salt, ligand and bipyridine in water in autoclave at 120°C for 4 d, cooling to room temp. during 8 h; elem. anal.;	65%

1,10-Phenanthroline (66-71-7) + 3,3',4,4'-diphenylsulfonetetracarboxylic acid dianhydride (2540-99-0) + copper(II) nitrate trihydrate + water (7732-18-5) → [Cu4(3,3',4,4'-diphenylsulfonetetracarboxylic acid-2H)4(1,10-phenanthroline)4]*12H2O

Conditions	Yield
In water High Pressure; mixt. of Cu(NO3)2*3H2O (0.10 mmol), 3,3',4,4'-diphenylsulfonetetracarboxylic dianhydride (0.05 mmol), phenenthroline (0.05 mmol) and H2O stirred(20 min) in air; heated in autoclave (160°C, 72 h); cooled to room temp. (5°C/h); elem. anal.;	65%

3,3',4,4'-diphenylsulfonetetracarboxylic acid dianhydride (2540-99-0) + water (7732-18-5) + cobalt(II) diacetate tetrahydrate (6147-53-1) + trans-1,2-bis(4-pyridyl)ethylene (1135-32-6) → {[Co2(dstc)(bpe)2(H2O)2]·2H2O}n

Conditions	Yield
In water at 150℃; for 72h; Autoclave;	65%

3,3',4,4'-diphenylsulfonetetracarboxylic acid dianhydride (2540-99-0) + silver nitrate + trans-1,2-bis(4-pyridyl)ethylene (1135-32-6) → [Ag(bpe)2]·H3dstc

Conditions	Yield
In water at 120℃; for 72h; Autoclave;	55%

3,3',4,4'-diphenylsulfonetetracarboxylic acid dianhydride (2540-99-0) + Pyridine-2,3-dicarboxylic acid (89-00-9) + ammonium chloride (12125-02-9) + copper dichloride → C58H24Cu2N22O2S

Conditions	Yield
With ammonium dimolybdate; urea for 10h; Heating; Reflux;	54%

3,3',4,4'-diphenylsulfonetetracarboxylic acid dianhydride (2540-99-0) + 1,2-bis(4'-pyridyl)ethane (4916-57-8) + water (7732-18-5) + cobalt(II) diacetate tetrahydrate (6147-53-1) → {[Co2(dstc)(bpe)2(H2O)2]·2H2O}n

Conditions	Yield
In water at 150℃; for 72h; Autoclave;	52%

3,3',4,4'-diphenylsulfonetetracarboxylic acid dianhydride (2540-99-0) + glycine (56-40-6) → C20H12N2O10S

Conditions	Yield
In N,N-dimethyl-formamide at 100℃;	52%

3,3',4,4'-diphenylsulfonetetracarboxylic acid dianhydride (2540-99-0) + Pyridine-2,3-dicarboxylic acid (89-00-9) + ammonium chloride (12125-02-9) + nickel dichloride → C58H24N22Ni2O2S

Conditions	Yield
With ammonium dimolybdate; urea for 10h; Heating; Reflux;	51%

3,3',4,4'-diphenylsulfonetetracarboxylic acid dianhydride (2540-99-0) + 1,3-di(4-pyridyl)propane (17252-51-6) + water (7732-18-5) + silver nitrate → [Ag(bpe)2]·H3dstc

Conditions	Yield
In water at 130℃; for 72h; Autoclave;	50%

3,3',4,4'-diphenylsulfonetetracarboxylic acid dianhydride (2540-99-0) + aluminium(III) chloride hexahydrate → ([Al(OH)(H2DPSTC)]·0.5H2O)

Conditions	Yield
With sodium hydroxide In water at 170℃; for 5h; Microwave irradiation;	50%

3,3',4,4'-diphenylsulfonetetracarboxylic acid dianhydride (2540-99-0) + C13H15Cl2N3 → C42H32Cl4N6O6S

Conditions	Yield
In toluene for 13h; Reflux;	46%

3,3',4,4'-diphenylsulfonetetracarboxylic acid dianhydride (2540-99-0) + Pyridine-2,3-dicarboxylic acid (89-00-9) + ammonium chloride (12125-02-9) + iron(II) chloride → C58H24Fe2N22O2S

Conditions	Yield
With ammonium dimolybdate; urea for 10h; Heating; Reflux;	44%

4,4'-bipyridine (553-26-4) + 3,3',4,4'-diphenylsulfonetetracarboxylic acid dianhydride (2540-99-0) + water (7732-18-5) + cadmium(II) acetate dihydrate (5743-04-4) + sodium hydroxide (1310-73-2) → ([Cd5(3,3',4,4'-diphenylsulfonetetracarboxylic acid-4H)2(4,4'-bipyridine)2(μ3-OH)2(H2O)4]*4H2O)n

Conditions	Yield
In water High Pressure; mixt. of Cd(CH3COO)2*2H2O (0.1 mmol), 3,3',4,4'-diphenylsulfonetetracarboxylic dianhydride (0.05 mmol), 4,4'-bipyridine (0.05 mmol), NaOH (0.2 mmol) and H2O stirred (20 min) in air; heated in autoclave (160°C,72 h); cooled to room temp. (5°C/h); elem. anal.;	43%

4,4'-bipyridine (553-26-4) + 3,3',4,4'-diphenylsulfonetetracarboxylic acid dianhydride (2540-99-0) + copper(II) nitrate trihydrate + water (7732-18-5) + sodium hydroxide (1310-73-2) → [Cu3(3,3',4,4'-diphenylsulfonetetracarboxylic acid-4H)(4,4'-bipyridine)(μ2-OH)2(H2O)2]n

Conditions	Yield
In water High Pressure; mixt. of Cu(NO3)2*3H2O (0.10 mmol), 3,3',4,4'-diphenylsulfonetetracarboxylic dianhydride (0.05 mmol), 4,4'-bipyridine (0.05 mmol), NaOH (0.2 mmol) and H2O stirred (20 min) in air; heated in autoclave (160°C, 72 h); cooled to room temp. (5°C/h); elem. anal.;	40%

1,10-Phenanthroline (66-71-7) + 3,3',4,4'-diphenylsulfonetetracarboxylic acid dianhydride (2540-99-0) + cadmium(II) acetate trihydrate + hydrazine hydrate (7803-57-8) → C16H8N4O6S(2-)*C12H8N2*2H2O*Cd(2+)

Conditions	Yield
In water at 170℃; for 96h; pH=8;	40%

3,3',4,4'-diphenylsulfonetetracarboxylic acid dianhydride (2540-99-0) + copper(II) nitrate trihydrate + water (7732-18-5) + trans-1,2-bis(4-pyridyl)ethylene (1135-32-6) → ([Cu2(3,3',4,4'-diphenylsulfonetetracarboxylic acid-4H)(1,2-bis(4-pyridyl)ethene)(H2O)2]*4H2O)n

Conditions	Yield
With NaOH In water High Pressure; mixt. of Cu(NO3)2*3H2O (0.10 mmol), 3,3',4,4'-diphenylsulfonetetracarboxylic dianhydride (0.05 mmol), 1,2-bis(4-pyridyl)ethene (0.05 mmol), NaOH(0.2 mmol) and H2O stirred (20 min) in air; heated in autoclave (160.de gree.C, 72 h); cooled to room temp. (5°C/h); elem. anal.;	36%

3,3',4,4'-diphenylsulfonetetracarboxylic acid dianhydride (2540-99-0) + Pyridine-2,3-dicarboxylic acid (89-00-9) + ammonium chloride (12125-02-9) + cobalt(II) chloride (7646-79-9) → C58H24Co2N22O2S

Conditions	Yield
With ammonium dimolybdate; urea for 10h; Heating; Reflux;	25%

3,3',4,4'-diphenylsulfonetetracarboxylic acid dianhydride (2540-99-0) + Pyridine-2,3-dicarboxylic acid (89-00-9) + ammonium chloride (12125-02-9) + manganese(ll) chloride → C58H24Mn2N22O2S

Conditions	Yield
With ammonium dimolybdate; urea for 10h; Heating; Reflux;	25%

N,N'-dipiperidylpropane (31951-46-9) + 3,3',4,4'-diphenylsulfonetetracarboxylic acid dianhydride (2540-99-0) + water (7732-18-5) + zinc(II) acetate dihydrate (5970-45-6) → [H2(1,3-bis(piperidyl)propane)]2[Zn2(4,4′-sulfonediphthalate)2]*H2O

Conditions	Yield
With triethylamine In methanol at 140℃; for 72h; pH=7; High pressure;	20%

3,3',4,4'-diphenylsulfonetetracarboxylic acid dianhydride (2540-99-0) + Pyridine-2,3-dicarboxylic acid (89-00-9) + ammonium chloride (12125-02-9) + zinc(II) chloride (7646-85-7) → C58H24N22O2SZn2

Conditions	Yield
With ammonium dimolybdate; urea for 10h; Heating; Reflux;	11%

Upstream product

• 10595-31-0 3,3’,4,4’-diphenylsulfonetetracarboxylic acid 
• 25884-43-9 3,3′,4,4′-diphenylsulfidetetracarboxylic dianhydride 

Downstream Products

• 10595-31-0 3,3’,4,4’-diphenylsulfonetetracarboxylic acid 

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