255873-36-0

Basic information

• Product Name: tert-butyl-N-{4-[allyl(dimethyl)silyl]-2-methoxyphenyl}carbamate
• Synonyms: tert-butyl-N-{4-[allyl(dimethyl)silyl]-2-methoxyphenyl}carbamate
• CAS NO: 255873-36-0
• Molecular Weight: 321.492
• Mol File: 255873-36-0.mol

Chemical Properties

• CAS DataBase Reference: tert-butyl-N-{4-[allyl(dimethyl)silyl]-2-methoxyphenyl}carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl-N-{4-[allyl(dimethyl)silyl]-2-methoxyphenyl}carbamate(255873-36-0)
• EPA Substance Registry System: tert-butyl-N-{4-[allyl(dimethyl)silyl]-2-methoxyphenyl}carbamate(255873-36-0)

Safety Data

• Hazardous Substances Data: 255873-36-0(Hazardous Substances Data)

Upstream product

• 4028-23-3 Allylchlorodimethylsilane 
• 262433-01-2 (4-bromo-2-methoxyphenyl)carbamic acid tert-butyl ester 
• 24424-99-5 di-tert-butyl dicarbonate 
• 59557-91-4 4-bromo-2-methoxyaniline 

Downstream Products

• 1226-63-7 1,3-bis(2-methoxyphenyl)urea 
• 5395-00-6 N-(2-methoxyphenyl)benzamide 
• 93-26-5 2-methoxyacetanilide 
• 3245-90-7 N-<4-Chlor-butyryl>-2-methoxy-anilin 
• 55860-22-5 2-chloro-N-(2-methoxyphenyl)acetamide 

Relevant articles and documents

Aryl carbamate derivatives, preperation and use thereof

The present invention relates to novel compounds, the preparation and use, particularly therapeutic, thereof. More specifically, it relates to compounds derived from aryl carbamates, the preparation and use thereof, particularly in the field of human and animal health. The compounds according to the invention are preferably 5-HT4 serotoninergic receptor ligands and can therefore be used in the therapeutic or prophylactic treatment of any disorder involving a 5-HT4 receptor. The invention also relates to pharmaceutical compositions comprising such compounds, the preparation and use thereof and treatment methods using said compounds.

Solid-phase synthesis of 2-methoxyaniline derivatives by the traceless silicon linker strategy

Application of the silicon linkage strategy to the solid-phase synthesis of the rich-electron o-anisidine derivatives is described. The protective t-Boc group was easily removed with B-catechol borane and the isocyanate was successfully prepared with the mild reagent (t-Boc)2O/DMAP. Carbamates, ureas or amides were prepared and released by cleavage with TFA at room temperature. This method can be used to prepare small focused libraries with biological activity at serotonin receptors.