25881-35-0

Upstream product

• 780-25-6 N-benzylidene benzylamine 
• 63000-01-1 diethyl 1-(N-benzylamino)-1-phenylmethylphosphonate 
• 6907-68-2 N-[phenyl(acetylamino)methyl]acetamide 
• 1795-31-9 tris(trimethylsilyl) phosphite 
• 100-52-7 benzaldehyde 
• 100-46-9 benzylamine 
• 126529-62-2 1-amino-1-phenylmethylphosphinic acid 
• 3376-26-9 N-Benzylidenebenzylamine N-oxide 
• 27845-50-7 (E)-N-benzylidenebenzylamine 
• 152879-31-7 (R,S)-<α-benzyl>phosphonsaeure-diethylester 

Downstream Products

• 18108-22-0 1-amino-1-phenylmethylphosphonic acid 

Relevant academic research and scientific papers

Synthesis of fluorescent aminophosphonates by green chemistry procedures

Fluorescent aminophosphonates were obtained using optimized conditions of the microwave-stimulated Kabachnik-Fields reaction. Unfortunately, in the case of more demanding, bulky amines and aldehydes this reaction failed to give the desired products.

A one-pot, three-step synthesis of α-aminophosphonic acids

A total of 20 α-aminophosphonic acids are synthesized in 73-89% yields via a one-pot, three-step procedure involving chlorotrimethylsilane- promoted condensation of carbonyl compounds and primary amines yielding azomethine intermediates, subsequent reaction with tris(trimethylsilyl) phosphite to give the corresponding trimethylsilylphosphonic esters and finally, mild cleavage with methanol-water. The wide scope and simple set-up and work-up procedures of the reported method allow the synthesis of a diverse set of α-aminophosphonic acids possessing two different functional groups. Georg Thieme Verlag Stuttgart, New York.

Application of bromotrimethylsilane and trialkyl phosphites for convenient and effective synthesis of aminophosphonic acids and corresponding monoalkyl and dialkyl esters

Application of bromotrimethylsilane (Br-TMS) in a mixture with trialkyl phosphite for synthesis of various aminophosphonic acids and esters was investigated. It was found, that appropriate mixtures of Br-TMS and trimethyl phosphite or triethyl phosphite were effective reagents for phosphorylation of various aldimines, obtained from aromatic and heteroaromatic aldehydes. Products of these reactions were corresponding aminophosphonic acids, or corresponding dialkyl or monoalkyl esters, respectively.

Syntheses of α-Aminophosphonic Acids from N-Ethoxyiminium Salts, II

Nitrones 2 obtained from aldehydes 1 are used for the synthesis of N-ethoxyiminium salts 3.These react with several esters of hydrogen phosphite 4 to give the N-methyl α-amino phosphonic esters 5 to 13.The N-benzyl α-amino phosphonic esters 24 and 25 can

SYNTHESE SYMMETRISCHER UND ASYMMETRISCHER α,α'-BIS(AMINOALKYL)PHOSPHINSAEUREN DES TYPS NH2CHR1(NH2CHR2)P(O)OH (R1 = Ph; R2 = Ph, Me)

α,α'-Bis(aminoalkyl)phosphinic acids are formed by amidoalkylation from aminoalkylphosphonous acids and arylidenebisamides.Key words: a,a'-Bis(aminoalkyl)phosphinic acids; amidoalkylation; aminoalkylphosphonous acids; NMR, titration.

SYNTHESIS, ACID-BASIC PROPERTIES AND CHELATING TENDENCY OF AMINOPHOSPHONIC AND AMINOPHOSPHINIC ACIDS WITH CHANGING ANALYTICAL-FUNCTIONAL GROUPS

The preparation of new N-substituted aminophosphinic and aminophosphonic acids have been described.Dissociation constants and stability constants of complexes towards metal cations have been determined.The obtained colored complexes have been characterized and their analytical application emphasized.

Preparation of amines by the reduction of imines with phosphorous acid

This invention relates to the preparation of amines by the reduction of imines with phosphorous acid, preferably under basic conditions.

α-Amino phosphonic acids

This invention relates to the preparation of α-amino phosphonic acids by the direct addition of phosphorous acid to imines.

Preparation of α-amino phosphonic acid derivatives

This invention relates to a process for preparing α-amino phosphonic acid derivatives which comprises reacting a nitrile with a phosphite ester under hydrogenation conditions; and to the α-amino phosphonic acid derivatives formed and uses thereof.