261635-77-2

Basic information

• Product Name: 6-CHLORO-4-(TRIFLUOROMETHYL)NICOTINICACID
• Synonyms: 6-Chloro-4-(trifluoromethyl)pyridine-3-carboxylic acid, 5-Carboxy-2-chloro-4-(trifluoromethyl)pyridine;6-Chloro-4-(trifluoromethyl)
• CAS NO: 261635-77-2
• Molecular Formula: C7H3ClF3NO2
• Molecular Weight: 225.56
• Product Categories: Pyridine series;Carboxylic Acids;Pyridines
• Mol File: 261635-77-2.mol

Chemical Properties

• Melting Point: 95-105°C
• Boiling Point: 309.9°Cat760mmHg
• Flash Point: 141.3°C
• Appearance: /
• Density: 1.603g/cm³
• Vapor Pressure: 0.000266mmHg at 25°C
• Refractive Index: 1.496
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 2.29±0.36(Predicted)
• CAS DataBase Reference: 6-CHLORO-4-(TRIFLUOROMETHYL)NICOTINICACID(CAS DataBase Reference)
• NIST Chemistry Reference: 6-CHLORO-4-(TRIFLUOROMETHYL)NICOTINICACID(261635-77-2)
• EPA Substance Registry System: 6-CHLORO-4-(TRIFLUOROMETHYL)NICOTINICACID(261635-77-2)

Safety Data

• Hazard Codes: Xi
• RIDADR: UN2811
• HazardClass: IRRITANT
• Hazardous Substances Data: 261635-77-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
6-Chloro-4-(trifluoromethyl)nicotinic acid is used as a building block for the synthesis of N-aryl heteroarylcarboxamides, which are known to inhibit the protein-protein binding of WDR5. This inhibition plays a crucial role in the regulation of various cellular processes, making it a potential target for the development of new therapeutic agents.
Organic Synthesis:
In the field of organic synthesis, 6-chloro-4-(trifluoromethyl)nicotinic acid serves as a valuable intermediate for the preparation of a wide range of compounds with diverse biological activities. Its unique structural features allow for further functionalization and modification, enabling the synthesis of novel molecules with potential applications in various industries, including pharmaceuticals, agrochemicals, and materials science.
Research and Development:
6-Chloro-4-(trifluoromethyl)nicotinic acid is also utilized in research and development efforts, where it can be employed to explore new chemical reactions, reaction mechanisms, and synthetic strategies. This contributes to the advancement of knowledge in the field of organic chemistry and may lead to the discovery of new compounds with improved properties and applications.

InChI:InChI=1/C7H3ClF3NO2/c8-5-1-4(7(9,10)11)3(2-12-5)6(13)14/h1-2H,(H,13,14)

Upstream product

• 124-38-9 carbon dioxide 
• 823221-93-8 5-bromo-2-chloro-4-(trifluoromethyl)pyridine 
• 401892-47-5 5-bromo-4-iodo-2-chloropyridine 
• 53939-30-3 5-bromo-2-chloropyridine 

Relevant articles and documents

INHIBITORS OF WDR5 PROTEIN-PROTEIN BINDING

The present application is directed to compounds of Formula I: (I) compositions comprising these compounds and their uses, for example as medicaments for the treatment of diseases, disorders or conditions mediated or treatable by inhibition of binding between WDR5 protein and its binding partners.

INHIBITORS OF WDR5 PROTEIN-PROTEIN BINDING

The present application is directed to compounds of Formula I: compounds comprising these compounds and their uses, for example as medicaments for the treatment of diseases, disorders or conditions mediated or treatable by inhibition of binding between WDR5 protein and its binding partners.

Logistic flexibility in the preparation of isomeric halopyridinecarboxylic acids

Although there are many conceivable ways to funtionalize, and specifically carboxylate, 2-chloro-4-(trifluoromethyl)pyridine optionally at all three vacant positions, it is more straightforward to prepare only the 2-chloro-4- (trifluoromethyl)pyridine-3-carboxylic acid (1) from this precursor and the other 6-chloro-4-(trifluoromethyl)pyridine-2- and -3-carboxylic acids (2 and 3) from a different one, viz. 5-bromo-2-chloro-4-(trifluoromethyl)pyridine. In the same manner, it proved more convenient to convert 5-chloro-2-(trifluoromethyl) pyridine in only two of the corresponding acids (6 and 7) and to make the third one (8) from 3-bromo-5-chloro-2-(trifluoromethyl)pyridine as an alternative starting material. All model substrates for functionalization were readily accessible from the correspondingly substituted chloroiodopyridine through heavy halogen displacement by in situ generated (trifluoromethyl)copper. Graphical Abstract