261925-40-0

Basic information

• Product Name: Thiophenemethanamine, a-2-thienyl-
• Synonyms: Thiophenemethanamine, a-2-thienyl-;C,C-Di-thiophen-2-yl-methylamine;di(thiophen-2-yl)methanamine;di(2-thiophenyl)methylamine
• CAS NO: 261925-40-0
• Molecular Formula: C₉H₉NS₂
• Molecular Weight: 195.30446
• Mol File: 261925-40-0.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Thiophenemethanamine, a-2-thienyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Thiophenemethanamine, a-2-thienyl-(261925-40-0)
• EPA Substance Registry System: Thiophenemethanamine, a-2-thienyl-(261925-40-0)

Safety Data

• Hazardous Substances Data: 261925-40-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Thiophenemethanamine, a-2-thienylis used as a building block in the synthesis of various pharmaceuticals for its potential antipsychotic and antidepressant properties. It plays a crucial role in the development of medications targeting neurological disorders, contributing to the treatment and management of these conditions.
Used in Agrochemical Industry:
In the agrochemical sector, Thiophenemethanamine, a-2-thienylserves as a key component in the production of various agrochemicals. Its incorporation into these products aids in enhancing crop protection and improving agricultural yields.
Used in Polymer and Dye Synthesis:
Thiophenemethanamine, a-2-thienylis utilized in the synthesis of polymers and dyes due to its unique chemical structure and properties. Its presence in these materials contributes to the development of novel materials with specific characteristics, such as color, stability, and other functional properties.
Safety Precautions:
It is essential to handle Thiophenemethanamine, a-2-thienylwith care, as it can be toxic and harmful if not used properly. Adequate safety measures, including the use of personal protective equipment and proper disposal methods, should be followed to minimize potential health risks and environmental impact.

Upstream product

• 1003-31-2 thiophene-2-carbonitrile 
• 1003-09-4 2-bromothiophene 
• 704-38-1 di(thiophen-2-yl)methanone 
• 98-03-3 thiophene-2-carbaldehyde 
• 10558-44-8 bis(2-thienyl)methanone oxime 
• 6973-84-8 2-[α-(2-thienyl)-α-hydroxymethyl]thiophene 

Relevant articles and documents

Pd-catalyzed enantioselective C-H iodination: Asymmetric synthesis of chiral diarylmethylamines

An enantioselective C-H iodination reaction using a mono-N-benzoyl- protected amino acid has been developed for the synthesis of chiral diarylmethylamines. The reaction uses iodine as the sole oxidant and proceeds at ambient temperature and under air.

Synthesis of homo- and heterobiarylmethylamines

A variety of homo- and heterobiarylmethylamines were prepared in modest to high yields via a convenient one-pot process. Georg Thieme Verlag Stuttgart.

Lewis acid-catalyzed direct amination of benzhydryl alcohols

The Lewis acid-mediated direct amination of benzylic alcohols is described, providing various benzylic amine derivatives in good yields under mild and environmentally benign conditions. Among the different Lewis acids tested, gold(III) proved to be the catalyst of choice for both chemical (yield, conversion) and practical reasons (a filtration over a silica pad is generally sufficient to obtain the corresponding benzylic amine in analytically pure form).

ISOTHIAZOLE DIOXIDES AS CXC- AND CC- CHEMOKINE RECEPTOR LIGANDS

Disclosed are novel compounds of the formula (IA): and the pharmaceutically acceptable salts and solvates thereof. D and E are different groups wherein one is N and the other is CR50. Examples of groups comprising Substituent A include heteroaryl, aryl, heterocycloalkyl, cycloalkyl, aryl, alkynyl, alkenyl, aminoalkyl, alkyl or amino. Examples of groups comprising Substituent B include aryl and heteroaryl. Also disclosed is a method of treating a chemokine mediated diseases, such as, cancer, angiogenisis, angiogenic ocular diseases, pulmonary diseases, multiple sclerosis, rheumatoid arthritis, osteoarthritis, stroke and cardiac reperfusion injury, pain (e.g., acute pain, acute and chronic inflammatory pain, and neuropathic pain) using a compound of formula IA.

THIADIAZOLEDIOXIDES AND THIADIAZOLEOXIDES AS CXC- AND CC-CHEMOKINE RECEPTOR LIGANDS

Disclosed are novel compounds of the formula (IA) and the pharmaceutically acceptable salts and solvates thereof. Examples of groups comprising Substituent A include heteroaryl, aryl, heterocycloalkyl, cycloalkyl, aryl, alkynyl, alkenyl, aminoalkyl, alkyl or amino. Examples of groups comprising Substituent B include aryl and heteroaryl. Also disclosed is a method of treating a chemokine mediated diseases, such as, cancer, angiogenisis, angiogenic ocular diseases, pulmonary diseases, multiple sclerosis, rheumatoid arthritis, osteoarthritis, stroke and cardiac reperfusion injury, acute pain, acute and chronic inflammatory pain, and neuropathic pain using a compound of formula (IA).

3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands

There are disclosed compounds of the formula or a pharmaceutically acceptable salt or solvate thereof which are useful for the treatment of chemokine-mediated diseases such as acute and chronic inflammatory disorders and cancer.

3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands

There are disclosed compounds of the formula or a pharmaceutically acceptable salt or solvate thereof which are useful for the treatment of chemokine-mediated diseases such as acute and chronic inflammatory disorders and cancer.

Azetidine derivatives, their preparation and medicaments containing them

The invention concerns compounds of formula (1) wherein: R represents a chain (A) or (B); R1 is methyl or ethyl; R2 is either an optionally substituted aromatic or an optionally substituted heteroaromatic ring; R3 and R4, identical or different, are either an optionally substituted aromatic or an optionally substituted heteroaromatic ring; R′ represents a hydrogen atom or a —CO—alk radical, their optical isomers, their salts, their preparation and medicines containing them.

Azetidine derivatives, their preparation and pharmaceutical compositions containing them

Compounds of formula: in which R represents a CR1R2, C═C(R5)SO2R6 or C═C(R7)SO2alk radical, their preparation and the pharmaceutical compositions containing them.