704-38-1

Usage

Uses

Used in Pharmaceutical Industry:
BIS(2-THIENYL) KETONE is used as a key intermediate in the synthesis of antitumor agents, specifically for the formation of hydantoins. These hydantoins are crucial in the development of cancer treatments, targeting and inhibiting the growth of tumor cells.
Additionally, BIS(2-THIENYL) KETONE is used as an impurity in the synthesis of Tiotropium Bromide (T444850), a muscarinic receptor antagonist. Tiotropium Bromide serves as a bronchodilator, helping to relax and widen the airways in patients with respiratory conditions such as chronic obstructive pulmonary disease (COPD) and asthma. The presence of BIS(2-THIENYL) KETONE in this synthesis process highlights its importance in the development of medications that improve lung function and overall respiratory health.

InChI:InChI=1/C9H6OS2/c10-9(7-3-1-5-11-7)8-4-2-6-12-8/h1-6H

Upstream product

• 201230-82-2 carbon monoxide 
• 88011-26-1 α-thienyl-mercury(II) bromide 
• 19226-36-9 3-phenyl-5H-1,4,2-dioxazol-5-one 
• 188290-36-0 thiophene 
• 78031-08-0 [(bromodifluoromethyl)sulfanyl]benzene 
• 5713-61-1 thiophen-2-yl magnesium bromide 
• 79-37-8 oxalyl dichloride 

Downstream Products

• 109407-70-7 di-2-thienyl ketone 2,4-dinitrophenyl hydrazone 
• 4341-34-8 2,2'-dithienylmethane 
• 201011-63-4 2,6-Di-tert-butyl-4-(di-thiophen-2-yl-methylene)-cyclohexa-2,5-dienone 
• 62032-07-9 5,5-di-(2-thienyl)-hydantoin 
• 201011-62-3 (5-{5-[(3,5-Di-tert-butyl-4-hydroxy-phenyl)-thiophen-2-yl-methyl]-thiophene-2-carbonyl}-thiophen-2-yl)-{5-[(3,5-di-tert-butyl-4-hydroxy-phenyl)-thiophen-2-yl-methyl]-thiophen-2-yl}-methanone 
• 137454-87-6 bis(thien-2-yl)mono(4-methoxyphenyl)methanol 
• 261925-40-0 di(2-thiophenyl)methylamine 
• 6973-84-8 2-[α-(2-thienyl)-α-hydroxymethyl]thiophene 

Relevant academic research and scientific papers

Co(III)-Catalyzed Synthesis of Quinazolines via C-H Activation of N-Sulfinylimines and Benzimidates

C-H activation of arenes has been established as an important strategy for heterocycle synthesis via annulations between arenes and unsaturated coupling partners. However, nitriles failed to act as such a coupling partner. Dioxazolones have been employed as a synthon of nitriles, and subsequent coupling with arenes such as N-sulfinylimines and benzimidates bearing a functionalizable directing group provided facile access to two classes of quinazolines under Co(III)-catalysis.

Friedel-crafts-type alkylation with bromodifluoro(phenylsulfanyl)methane through α-fluorocarbocations: Syntheses of thioesters, benzophenones and xanthones

Bromodifluoro(phenylsulfanyl)methane undergoes a Friedel-Crafts-type alkylation, through α-fluorocarbocations, with activated aromatic compounds yielding thioesters and/or benzophenones. The methodology has been applied to the synthesis of naturally occurring xanthone derivatives.

A Direct Access to α-Diones from Oxalyl Chloride

Cross-coupling reactions of oxalyl chloride with organocopper reagents, derived from Grignard reagents, cuprous bromide, and lithium bromide, provide a simple and straightforward method for the synthesis of symmetrical α-diones in very good yields.