10558-44-8

Usage

Uses

Used in Chemical Analysis:
BIS(2-THIENYL) KETOXIME is used as an analytical reagent for its ability to form stable complex compounds with metals, facilitating metal ion analysis and determination.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, BIS(2-THIENYL) KETOXIME is used as a chemical intermediate and analytical reagent, contributing to the development and quality control of pharmaceutical products.
Used in Cosmetics Industry:
BIS(2-THIENYL) KETOXIME is utilized in the cosmetics industry as an ingredient in various formulations, taking advantage of its metal complexation properties to enhance product performance and stability.
Used in Agriculture:
In agriculture, BIS(2-THIENYL) KETOXIME is employed for its analytical capabilities in assessing the metal content in soil and water, which is crucial for optimizing crop growth and health.
Used in Organic Synthesis:
BIS(2-THIENYL) KETOXIME is used as a building block in organic synthesis, leveraging its reactivity and metal-forming properties to create new organic compounds.
Used in Coordination Chemistry:
In coordination chemistry, BIS(2-THIENYL) KETOXIME is used for the synthesis of coordination compounds, exploring its potential in creating novel metal complexes with unique properties and applications.

InChI:InChI=1/C9H7NOS2/c11-10-9(7-3-1-5-12-7)8-4-2-6-13-8/h1-6,11H

Upstream product

• 704-38-1 di(thiophen-2-yl)methanone 
• 5470-11-1 hydroxylamine hydrochloride 
• 6973-84-8 2-[α-(2-thienyl)-α-hydroxymethyl]thiophene 
• 98-03-3 thiophene-2-carbaldehyde 

Downstream Products

• 261925-40-0 di(2-thiophenyl)methylamine 
• 1131328-99-8 bis(2-thienyl)ketone O-pentafluorobenzoyl oxime 

Relevant academic research and scientific papers

Access to Cyanoimines Enabled by Dual Photoredox/Copper-Catalyzed Cyanation of O-Acyl Oximes

An efficient strategy for the synthesis of pharmaceutically important and synthetically useful cyanoimines, as well as cyanamides, has been described. This strategy is enabled by dual photoredox/copper-catalyzed cyanation of O-acyl oximes or O-acyl hydroxamides. This state of the art protocol for cyanoimines and cyanamides features readily available starting materials, mild reaction conditions, good functional group tolerance, and operational simplicity. The resultant cyanoimines can be transformed into structurally diverse and functionally important N-containing heterocycles.

Pd-catalyzed enantioselective C-H iodination: Asymmetric synthesis of chiral diarylmethylamines

An enantioselective C-H iodination reaction using a mono-N-benzoyl- protected amino acid has been developed for the synthesis of chiral diarylmethylamines. The reaction uses iodine as the sole oxidant and proceeds at ambient temperature and under air.

Palladium-catalyzed annulation of acyloximes with arynes (or alkynes): Synthesis of phenanthridines and isoquinolines

(Chemical Equation Presented) Intermolecular insertion: A palladium-catalyzed domino aminopalladation/C-H functionalization sequence has been developed, and provides access to functionalized phenanthridines and isoquinolines (see scheme; Tf = triflate, TM

ISOTHIAZOLE DIOXIDES AS CXC- AND CC- CHEMOKINE RECEPTOR LIGANDS

Disclosed are novel compounds of the formula (IA): and the pharmaceutically acceptable salts and solvates thereof. D and E are different groups wherein one is N and the other is CR50. Examples of groups comprising Substituent A include heteroaryl, aryl, heterocycloalkyl, cycloalkyl, aryl, alkynyl, alkenyl, aminoalkyl, alkyl or amino. Examples of groups comprising Substituent B include aryl and heteroaryl. Also disclosed is a method of treating a chemokine mediated diseases, such as, cancer, angiogenisis, angiogenic ocular diseases, pulmonary diseases, multiple sclerosis, rheumatoid arthritis, osteoarthritis, stroke and cardiac reperfusion injury, pain (e.g., acute pain, acute and chronic inflammatory pain, and neuropathic pain) using a compound of formula IA.

3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands

There are disclosed compounds of the formula or a pharmaceutically acceptable salt or solvate thereof which are useful for the treatment of chemokine-mediated diseases such as acute and chronic inflammatory disorders and cancer.

THIADIAZOLEDIOXIDES AND THIADIAZOLEOXIDES AS CXC- AND CC-CHEMOKINE RECEPTOR LIGANDS

Disclosed are novel compounds of the formula (IA) and the pharmaceutically acceptable salts and solvates thereof. Examples of groups comprising Substituent A include heteroaryl, aryl, heterocycloalkyl, cycloalkyl, aryl, alkynyl, alkenyl, aminoalkyl, alkyl or amino. Examples of groups comprising Substituent B include aryl and heteroaryl. Also disclosed is a method of treating a chemokine mediated diseases, such as, cancer, angiogenisis, angiogenic ocular diseases, pulmonary diseases, multiple sclerosis, rheumatoid arthritis, osteoarthritis, stroke and cardiac reperfusion injury, acute pain, acute and chronic inflammatory pain, and neuropathic pain using a compound of formula (IA).

3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands

There are disclosed compounds of the formula or a pharmaceutically acceptable salt or solvate thereof which are useful for the treatment of chemokine-mediated diseases such as acute and chronic inflammatory disorders and cancer.