263159-64-4

Basic information

• Product Name: 2-BROMO-3-METHYLBENZONITRILE
• Synonyms: 2-BROMO-3-METHYLBENZONITRILE;2-BroMo-3-Methylbenzonitrile 97%;Benzonitrile, 2-bromo-3-methyl-
• CAS NO: 263159-64-4
• Molecular Formula: C₈H₆BrN
• Molecular Weight: 196.04394
• Product Categories: Aromatic Nitriles;Bromine Compounds;C8 to C9;Cyanides/Nitriles;Nitrogen Compounds
• Mol File: 263159-64-4.mol

Chemical Properties

• Melting Point: 67-71 °C
• Boiling Point: 286.8±28.0 °C(Predicted)
• Appearance: /
• Density: 1.51±0.1 g/cm3(Predicted)
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: 2-BROMO-3-METHYLBENZONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BROMO-3-METHYLBENZONITRILE(263159-64-4)
• EPA Substance Registry System: 2-BROMO-3-METHYLBENZONITRILE(263159-64-4)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 263159-64-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-BROMO-3-METHYLBENZONITRILE is used as a synthetic intermediate for the production of pharmaceuticals, contributing to the development of new drugs and medicines.
Used in Agrochemical Industry:
In the agrochemical sector, 2-BROMO-3-METHYLBENZONITRILE serves as an intermediate in the synthesis of agrochemicals, aiding in the creation of products for agricultural applications such as pesticides and herbicides.
Used in Organic Synthesis:
2-BROMO-3-METHYLBENZONITRILE is utilized as a building block in organic synthesis, enabling the preparation of a range of other organic compounds for diverse applications.
Used in Materials Science:
2-BROMO-3-METHYLBENZONITRILE is used in the production of liquid crystals, a key component in various display technologies, and as a reagent in chemical reactions, highlighting its importance in the advancement of materials science.

Upstream product

• 101421-85-6 2-bromo-3-methylbenzamide 
• 53663-39-1 3-methyl-2-bromobenzoic acid 
• 54879-20-8 2-bromo-3-methylaniline 
• 143-33-9 sodium cyanide 

Downstream Products

• 1086429-87-9 2-bromo-3-(bromomethyl)benzonitrile 
• 1269411-33-7 C₁₄H₁₇BrO₃ 
• 1268335-57-4 2-bromo-3-formylbenzyl acetate 
• 1268335-59-6 2-bromo-3-(4-hydroxybutyl)benzyl acetate 
• 1268335-60-9 2-bromo-3-(4-oxobutyl)benzyl acetate 
• 1268335-61-0 4-(3-(acetoxymethyl)-2-bromophenyl)butanoic acid 
• 1268335-62-1 methyl 4-(3-(acetoxymethyl)-2-bromophenyl)butanoate 
• 1268335-63-2 methyl 4-(3-(acetoxymethyl)-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)butanoate 
• 1268335-69-8 2-bromo-3-(3-oxobutyl)benzyl acetate 
• 1268335-70-1 3-(3-oxobutyl)-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl acetate 
• 24188-72-5 5-methylisoquinolin-1(2Η)-one 
• 1319196-56-9 2-(2-amino-3-morpholinoquinolin-6-yl)-3-methylbenzonitrile 
• 1319194-60-9 (2-(2-amino-3-(tetrahydro-2H-pyran-4-yl)quinolin-6-yl)-3-methylphenyl)(pyridin-2-yl)methanone 

Relevant articles and documents

SHP2 PHOSPHATASE INHIBITORS AND METHODS OF USE THEREOF

The present disclosure relates to novel compounds including formula (X) and pharmaceutical compositions thereof, and methods for inhibiting the activity of SHP2 phosphatase with the compounds and compositions of the disclosure. The present disclosure further relates to, but is not limited to, methods for treating disorders associated with SHP2 deregulation with the compounds and compositions of the disclosure.

Dehydration of Amides to Nitriles under Conditions of a Catalytic Appel Reaction

A highly expedient protocol for a catalytic Appel-type dehydration of amides to nitriles has been developed that employs oxalyl chloride and triethylamine along with triphenylphosphine oxide as a catalyst. The reactions are usually complete in less than 10 min with only a 1 mol % catalyst loading. The reaction scope includes aromatic, heteroaromatic, and aliphatic amides, including derivatives of α-hydroxy and α-amino acids.

MACROCYCLIC DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES

The invention relates to compounds of formula (Φ) as further defined herein and to the pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising such compounds and salts, and to the uses thereof. The compounds and salts of the present invention inhibit anaplastic lymphoma kinase (ALK) and/or EML4-ALK and are useful for treating or ameliorating abnormal cell proliferative disorders, such as cancer.

Synthesis and structure-activity relationships of novel benzoxaboroles as a new class of antimalarial agents

A series of boron-containing benzoxaborole compounds was designed and synthesized for a structure-activity relationship investigation surrounding 7-(HOOCCH2CH2)-1,3-dihydro-1-hydroxy-2,1-benzoxaborole (1) with the goal of discovering

BORON-CONTAINING SMALL MOLECULES AS ANTIPROTOZOAL AGENTS

This invention provides novel compounds of the following formula useful for treating protozoal infections, pharmaceutical compositions containing such compounds, as well as combinations of these compounds with at least one additional therapeutically effective agent.

Cleft-type diamidinium receptors for dicarboxylate binding in protic solvents

A series of potential cleft-type receptors for dicarboxylate substrates were prepared by attachment of two phenylamidinium ions to either naphthalene or 1,1'-binaphthalene scaffolds. Their synthesis (Schemes 1-4) involved the Pd0-catalyzed cros