263888-58-0

Basic information

• Product Name: ISOINDOLINE-5-CARBONITRILE
• Synonyms: ISOINDOLINE-5-CARBONITRILE;2,3-Dihydro-1H-isoindole-5-carbonitrile
• CAS NO: 263888-58-0
• Molecular Formula: C₉H₈N₂
• Molecular Weight: 144.17
• Mol File: 263888-58-0.mol

Chemical Properties

• Boiling Point: 273.2±40.0 °C(Predicted)
• Appearance: /
• Density: 1.18±0.1 g/cm3(Predicted)
• PKA: 7.69±0.20(Predicted)
• CAS DataBase Reference: ISOINDOLINE-5-CARBONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: ISOINDOLINE-5-CARBONITRILE(263888-58-0)
• EPA Substance Registry System: ISOINDOLINE-5-CARBONITRILE(263888-58-0)

Safety Data

• Hazardous Substances Data: 263888-58-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
ISOINDOLINE-5-CARBONITRILE is used as a building block for the synthesis of various pharmaceuticals due to its ability to participate in multiple synthetic reactions, making it a valuable component in drug development.
Used in Pesticide Industry:
ISOINDOLINE-5-CARBONITRILE is used as a key intermediate in the production of pesticides, contributing to the development of effective and targeted pest control solutions.
Used in Dye Industry:
ISOINDOLINE-5-CARBONITRILE is utilized as a starting material for the synthesis of dyes, playing a crucial role in the creation of a diverse range of colorants for various applications.
Used in Fine Chemicals Production:
ISOINDOLINE-5-CARBONITRILE is employed in the production of fine chemicals, where its unique properties and reactivity contribute to the synthesis of high-quality specialty chemicals.
Used in Organic Synthesis:
ISOINDOLINE-5-CARBONITRILE is used as a versatile intermediate in organic synthesis, enabling the creation of a wide array of chemical compounds for various industries and applications.

Upstream product

• 263888-56-8 tert-butyl 5-cyanoisoindoline-2-carboxylate 
• 127168-88-1 5-methoxy-2,3-dihydro-1H-isoindole 
• 263888-57-9 5-trifluoromethanesulfonyloxy-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester 
• 127168-84-7 5-bromoisoindoline 
• 6941-75-9 5-Bromoisoindoline-1,3-dione 
• 201940-08-1 5-bromo-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester 
• 226070-47-9 tert-butyl 5-hydroxyisoindoline-2-carboxylate 
• 54544-67-1 5-hydroxyisoindoline 

Downstream Products

• 437652-04-5 2-[2-(4-amino-cyclohexyl)-ethyl]-2,3-dihydro-1H-isoindole-5-carbonitrile 
• 437651-10-0 {4-[2-(5-cyano-1,3-dihydro-isoindol-2-yl)-ethyl]-cyclohexyl}-carbamic acid tert-butyl ester 

Relevant articles and documents

RHO KINASE INHIBITORS

The invention provides novel inhibitors of ROCK1 and/or ROCK2. Also provided are methods of treating diseases and disorders involving inhibiting ROCK1 and/or ROCK2. The present invention includes pharmaceutical compositions comprising the compounds of the invention and a pharmaceutically acceptable carrier and/or diluents. The present invention includes compositions comprising a substantially pure compound of the invention and a pharmaceutically acceptable salt, steroisomer, or hydrate thereof: and a pharmaceutically acceptable excipient and/or diluents.

Design and synthesis of novel 2,3-dihydro-1H-isoindoles with high affinity and selectivity for the dopamine D3 receptor

Starting from the tetrahydroisoquinoline SB-2770111, a novel series of 5-substituted-2,3-dihydro-1H-isoindoles has been designed. Subsequent optimisation resulted in identification of 19. which has high affinity for the dopamine D3 receptor (pKi 8.3) and ≥ 100-fold selectivity over other aminergic receptors. In rat studies 19 was brain penetrant with an excellent pharmacokinetic profile (oral bioavailability 77%. t1/2 5.2h).