2652-27-9

Basic information

• Product Name: Ethanone, 1-[2-hydroxy-3,4-bis(phenylmethoxy)phenyl]-
• CAS NO: 2652-27-9
• Molecular Formula: C22H20O4
• Molecular Weight: 348.398
• Mol File: 2652-27-9.mol

Chemical Properties

• CAS DataBase Reference: Ethanone, 1-[2-hydroxy-3,4-bis(phenylmethoxy)phenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 1-[2-hydroxy-3,4-bis(phenylmethoxy)phenyl]-(2652-27-9)
• EPA Substance Registry System: Ethanone, 1-[2-hydroxy-3,4-bis(phenylmethoxy)phenyl]-(2652-27-9)

Safety Data

• Hazardous Substances Data: 2652-27-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Ethanone, 1-[2-hydroxy-3,4-bis(phenylmethoxy)phenyl]is used as an intermediate in the synthesis of other compounds for pharmaceutical applications. Its unique structure allows it to be a key component in the development of new drugs and medications.
Used in Chemical Industry:
In the chemical industry, Ethanone, 1-[2-hydroxy-3,4-bis(phenylmethoxy)phenyl]is used as a building block for the creation of more complex molecules. Its versatility in chemical reactions makes it a valuable asset in the synthesis of a wide range of chemical products.
It is important to handle Ethanone, 1-[2-hydroxy-3,4-bis(phenylmethoxy)phenyl]with care and to follow safety guidelines when working with it in laboratory or industrial settings to ensure the safety of both the individuals and the environment.

Upstream product

• 528-21-2 2',3',4'-trihydroxyacetophenone 
• 100-44-7 benzyl chloride 
• 100-39-0 benzyl bromide 
• 87-66-1 2-hydroxyresorcinol 
• 50439-63-9 1-(2,3,4-tris(benzyloxy)phenyl)ethanone 
• 1024-41-5 benzyl tosylate 

Downstream Products

• 1196971-28-4 (E)-3',4'-dibenzyloxy-2'-(3,4-dimethoxycinnamoyloxy)acetophenone 
• 2652-28-0 3',4',4-Tribenzyloxy-2'-hydroxy-chalkon 
• 786706-00-1 7,8-bis-(1,1-dimethyl-prop-2-ynyloxy)-2-phenyl-4H-chromen-4-one 
• 786706-01-2 7,8-bis-(1,1-dimethyl-allyloxy)-2-phenyl-4H-chromen-4-one 
• 500866-00-2 C₂₉H₂₂O₄ 
• 1377187-73-9 C₃₆H₂₈O₅ 
• 1033873-86-7 C₂₅H₂₆O₄ 
• 38183-03-8 7,8-dihydroxyflavone 
• 147711-26-0 7,8,4'-Trihydroxyflavone 
• 93827-33-9 C₂₉H₂₄O₄ 
• 1610522-93-4 7,8-bis(benzyloxy)-4-hydroxy-2H-chromen-2-one 
• 1267949-42-7 7,8-dihydroxy-4-(3-hydroxy-4-methoxyphenyl)-3,4-dihydrocoumarin 
• 1642784-52-8 7,8-bis(benzyloxy)-4-(3-(benzyloxy)-4-methoxyphenyl)-2H-chromen-2-one 
• 1642785-09-8 7,8-bis(benzyloxy)-2-oxo-2H-chromen-4-yl trifluoromethanesulfonate 

Relevant articles and documents

COMPOUND FOR TREATING NERVOUS SYSTEM DISEASES AND USE THEREOF

The present invention specifically relates to a class of compounds for treating nervous system diseases, which are compounds as shown by formula (I) or a stereoisomer, a geometric isomer, a tautomer, a solvate, a metabolite, a pharmaceutically acceptable

Preparation method of 7,8-dihydroxy flavone

The invention relates to a preparation method of 7,8-dihydroxy flavone, and belongs to the technical field of synthesis of medical intermediates. The preparation method comprises the following steps:by taking pyrogallol as a raw material, introducing an acetyl group to synthesize DHF1; protecting three phenolic hydroxyl groups to synthesize DHF2; selectively reducing the ortho-hydroxyl group of the acetyl group to synthesize DHF3; carrying out an aldol condensation reaction on DHF3 and benzaldehyde to prepare DHF4; carrying out a cyclization reaction under the condition of iodine catalysis toobtain DHF5; and finally carrying out a hydrolysis reaction to generate the final product. The method is simple and convenient to operate, reasonable in reaction process, low in production cost, goodin product quality, free of environmental pollution and suitable for industrial production, wherein the content of the product is higher than 98%.

Design and synthesis of 3,3′-biscoumarin-based c-Met inhibitors

A library of biscoumarin-based c-Met inhibitors was synthesized, based on optimization of 3,3′-biscoumarin hit 3, which was identified as a non-ATP competitive inhibitor of c-Met from a diverse library of coumarin derivatives. Among these compounds, 38 and 40 not only showed potent enzyme activities with IC50 values of 107 nM and 30 nM, respectively, but also inhibited c-Met phosphorylation in BaF3/TPR-Met and EBC-1 cells. This journal is the Partner Organisations 2014.

Studies on gambogic acid (IV): Exploring structure-activity relationship with IκB kinase-beta (IKKβ)

Previously we have reported a series of gambogic acid's analogs and have identified a compound that possessed comparable in vitro growth inhibitory effect as gambogic acid. However, their target protein as well as the key pharmacophoric motifs on the target have not been identified yet. Herein we report that gambogic acid and its analogs inhibit the activity of IκB Kinase-beta (IKKβ) through suppressing the activation of TNFα/NF-κB pathway, which in turn induces A549 and U251 cell apoptosis. IKKβ can serve as one of gambogic acid's targets. The preparation of the compounds was carefully discussed in the article. Caged 4-oxa-tricyclo[4.3.1.03,7]dec-2-one xanthone, which was identified as the pharmacophoric scaffold, represents a promising therapeutic agent for cancer and useful probe against NF-κB pathway.

Effects of electron-withdrawing substituents on DPPH radical scavenging reactions of protocatechuic acid and its analogues in alcoholic solvents

The DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging activity of protocatechuic acid (3,4-dihydroxybenzoic acid) and its related catechols was examined. Compounds possessing strong electron-withdrawing substituents showed high activity. NMR analysis of the reaction mixtures of catechols and DPPH radical in methanol showed the formation of methanol adducts. The results suggest that high radical scavenging activity of catechols in alcohol is due to a nucleophilic addition of an alcohol molecule on o-quinones, which leads to a regeneration of a catechol structure. Furthermore, the radical scavenging activity in alcohols would largely depend on the electron-withdrawing/donating substituents, since they affect the susceptibility toward nucleophilic attacks on o-quinone.