50439-63-9

Basic information

• Product Name: Ethanone, 1-[2,3,4-tris(phenylmethoxy)phenyl]-
• CAS NO: 50439-63-9
• Molecular Formula: C29H26O4
• Molecular Weight: 438.523
• Mol File: 50439-63-9.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Ethanone, 1-[2,3,4-tris(phenylmethoxy)phenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 1-[2,3,4-tris(phenylmethoxy)phenyl]-(50439-63-9)
• EPA Substance Registry System: Ethanone, 1-[2,3,4-tris(phenylmethoxy)phenyl]-(50439-63-9)

Safety Data

• Hazardous Substances Data: 50439-63-9(Hazardous Substances Data)

Upstream product

• 87-66-1 2-hydroxyresorcinol 
• 528-21-2 2',3',4'-trihydroxyacetophenone 
• 100-39-0 benzyl bromide 
• 100-44-7 benzyl chloride 

Downstream Products

• 500866-00-2 C₂₉H₂₂O₄ 
• 93827-33-9 C₂₉H₂₄O₄ 
• 38183-03-8 7,8-dihydroxyflavone 
• 2652-27-9 1-(3,4-bis(benzyloxy)-2-hydroxyphenyl)ethanone 
• 147711-26-0 7,8,4'-Trihydroxyflavone 
• 1610522-93-4 7,8-bis(benzyloxy)-4-hydroxy-2H-chromen-2-one 
• 96754-80-2 [(2S,3R)-3-(2,3-Dihydro-benzo[1,4]dioxin-6-yl)-oxiranyl]-(2,3,4-tris-benzyloxy-phenyl)-methanone 
• 700843-50-1 2',3',4'-tribenzyloxychalcone-4-carbaldehyde 
• 700843-53-4 3',4'-dibenzyloxy-2'-hydroxychalcone-4-carbaldehyde 
• 700843-51-2 7,8-dibenzyloxyflavone-4'-carbaldehyde 
• 700843-42-1 2',3',4'-tribenzyloxy-4-(diethoxymethyl)chalcone 
• 96755-21-4 (E)-3-(2,3-Dihydro-benzo[1,4]dioxin-6-yl)-1-(2,3,4-tris-benzyloxy-phenyl)-propenone 

Relevant articles and documents

Bisphosphonate-Linked TrkB Agonist: Cochlea-Targeted Delivery of a Neurotrophic Agent as a Strategy for the Treatment of Hearing Loss

Hearing loss affects more than two-thirds of the elderly population, and more than 17% of all adults in the U.S. Sensorineural hearing loss related to noise exposure or aging is associated with loss of inner ear sensory hair cells (HCs), cochlear spiral ganglion neurons (SGNs), and ribbon synapses between HCs and SGNs, stimulating intense interest in therapies to regenerate synaptic function. 7,8-Dihydroxyflavone (DHF) is a selective and potent agonist of tropomyosin receptor kinase B (TrkB) and protects the neuron from apoptosis. Despite evidence that TrkB agonists can promote survival of SGNs, local delivery of drugs such as DHF to the inner ear remains a challenge. We previously demonstrated in an animal model that a fluorescently labeled bisphosphonate, 6-FAM-Zol, administered to the round window membrane penetrated the membrane and diffused throughout the cochlea. Given their affinity for bone mineral, including cochlear bone, bisphosphonates offer an intriguing modality for targeted delivery of neurotrophic agents to the SGNs to promote survival, neurite outgrowth, and, potentially, regeneration of synapses between HCs and SGNs. The design and synthesis of a bisphosphonate conjugate of DHF (Ris-DHF) is presented, with a preliminary evaluation of its neurotrophic activity. Ris-DHF increases neurite outgrowth in vitro, maintains this ability after binding to hydroxyapatite, and regenerates synapses in kainic acid-damaged cochlear organ of Corti explants dissected in vitro with attached SGNs. The results suggest that bisphosphonate-TrkB agonist conjugates have promise as a novel approach to targeted delivery of drugs to treat sensorineural hearing loss.

Design and synthesis of 3,3′-biscoumarin-based c-Met inhibitors

A library of biscoumarin-based c-Met inhibitors was synthesized, based on optimization of 3,3′-biscoumarin hit 3, which was identified as a non-ATP competitive inhibitor of c-Met from a diverse library of coumarin derivatives. Among these compounds, 38 and 40 not only showed potent enzyme activities with IC50 values of 107 nM and 30 nM, respectively, but also inhibited c-Met phosphorylation in BaF3/TPR-Met and EBC-1 cells. This journal is the Partner Organisations 2014.

[60]Fullerene-flavonoid dyads

A range of fullerene-chalcone, fullerene-flavone, and fullerene-chromone dyads, including a bis(flavonyl)-fullerene dyad, were prepared by 1,3-dipolar cycloaddition reactions of azomethine ylides to C60 and by cyclopropanation of C60 with flavonyl malonates. Synthetic and natural flavonoid derivatives were used as starting materials.