cas 26654-39-7, 4,4-DIMETHYL-2-OXAZOLIDINONE

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LOW TOXICITY NMP SUBSTITUTES AND USES THEREOF
The present technology is directed to compounds Formulas I, II, III, and IV as well as compositions that include one or more of the compounds and methods of making the compounds. In particular, the present compounds may be used as a replacement for NMP in compositions to produce lower toxicity compositions.
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Paragraph 0150

(2021/08/20)

Photocatalytic Intramolecular C-H Amination Using N-Oxyureas as Nitrene Precursors
Nitrenes are remarkable high-energy chemical species that enable direct C-N bond formation, typically via controlled reactions of metal-stabilized nitrenes. Here, in contrast, the combined use of photocatalysis with careful engineering of the precursor enabled C-H amination forming imidazolidinones and related nitrogen heterocycles from readily accessible hydroxylamine precursors. Preliminary mechanistic results are consistent with the formation of free carbamoyl triplet nitrenes as reactive intermediates.
Ivanovich, Ryan A.,Polat, Dilan E.,Beauchemin, André M.
supporting information
p. 6360 - 6364
(2020/09/02)

Versatile Cp*Co(III)(LX) Catalyst System for Selective Intramolecular C-H Amidation Reactions
Herein, we report the development of a tailored cobalt catalyst system of Cp*Co(III)(LX) toward intramolecular C-H nitrene insertion of azidoformates to afford cyclic carbamates. The cobalt complexes were easy to prepare and bench-stable, thus offering a convenient reaction protocol. The catalytic reactivity was significantly improved by the electronic tuning of the bidentate LX ligands, and the observed regioselectivity was rationalized by the conformational analysis and DFT calculations of the transition states. The superior performance of the newly developed cobalt catalyst system could be broadly applied to both C(sp2)-H and C(sp3)-H carbamation reactions under mild conditions.
Chang, Sukbok,Jung, Hoimin,Kim, Dongwook,Lee, Jeonghyo,Lee, Jia,Park, Juhyeon
supporting information
p. 12324 - 12332
(2020/08/06)

Tuning Triplet Energy Transfer of Hydroxamates as the Nitrene Precursor for Intramolecular C(sp3)-H Amidation
Reported herein is the design of a photosensitization strategy to generate triplet nitrenes and its applicability for the intramolecular C-H amidation reactions. Substrate optimization by tuning physical organic parameters according to the proposed energy transfer pathway led us to identify hydroxamates as a convenient nitrene precursor. While more classical nitrene sources, representatively organic azides, were ineffective under the current photosensitization conditions, hydroxamates, which are readily available from alcohols or carboxylic acids, are highly efficient in accessing synthetically valuable 2-oxazolidinones and γ-lactams by visible light. Mechanism studies supported our working hypothesis that the energy transfer path is mainly operative.
Chang, Sukbok,Jung, Hoimin,Keum, Hyeyun,Kweon, Jeonguk
supporting information
p. 5811 - 5818
(2020/04/10)

Scalable Synthesis of Esp and Rhodium(II) Carboxylates from Acetylacetone and RhCl3· xH2O
Rhodium(II) carboxylates are privileged catalysts for the most challenging carbene-, nitrene-, and oxo-transfer reactions. In this work, we address the strategic challenges of current organic and inorganic synthesis methods to access these rhodium(II) complexes through an oxidative rearrangement strategy and a reductive ligation reaction. These studies illustrate the multiple benefits of oxidative rearrangement in the process-scale synthesis of congested carboxylates over nitrile anion alkylation reactions, and the impressive effect of inorganic additives in the reductive ligation of rhodium(III) salts.
Martínez-Castro, Elisa,Mendoza, Abraham,Suárez-Pantiga, Samuel
supporting information
p. 1207 - 1212
(2020/07/15)

A synthetic penem antibiotics of hand natural auxiliary base preparation method
The present invention relates to the field of medicinal chemistry for the preparation of the product, in particular to a synthetic penem antibiotics of hand natural auxiliary base preparation method. The synthetic penem antibiotics of hand natural auxilia
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Paragraph 014; 0017; 0019

(2019/07/04)

Irbinitinib intermediates for preparation of (by machine translation)
The invention belongs to the organic synthesis and bulk drug preparation technology field, in particular to the treatment of breast cancer drug Irbinitinib preparation method and intermediate, comprising the steps of: 2 - methyl - 4 - nitro-phenol (formul
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Paragraph 0076; 0077; 0078; 0100; 0101; 0102

(2019/07/10)

Safe synthesis of alkylhydroxy and alkylamino nitramines
Three different protocols for the syntheses of hydroxyalkylnitramines are presented and compared. Safety issues regarding the synthesis of nitramines are also discussed.
Antonsen, Simen,Aursnes, Marius,Gallantree-Smith, Harrison,Dye, Christian,Stenstr?m, Yngve
(2016/12/30)

PROCESS FOR THE PREPARATION OF N-IODOAMIDES
The present invention provides new stable crystalline N-iodoamides - 1-iodo- 3,5,5-trimethylhydantoin (1-ITMH) and 3-iodo-4,4-dimethyl-2-oxazolidinone (IDMO). The present invention further provides a process for the preparation of organic iodides using N-iodoamides of this invention and recovery of the amide co-products from waste water.
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Paragraph 00121-00122

(2015/05/26)

Aluminium-Catalysed Oxazolidinone Synthesis and their Conversion into Functional Non-Symmetrical Ureas
An efficient and practical aluminium-catalysed approach towards a range of functional oxazolidinones is reported. The method is based on cheap and readily available starting materials including terminal and internal (bicyclic) epoxides and phenyl carbamate. The oxazolidinones serve as highly useful synthons for the high yield preparation of non-symmetrical ureas by nucleophilic ring-opening affording the targeted urea compounds with excellent functional group diversity, high regioselectivity and isolated yields up to >99%.
Laserna, Victor,Guo, Wusheng,Kleij, Arjan W.
p. 2849 - 2854
(2015/09/28)

Catalytic fluoride triggers dehydrative oxazolidinone synthesis from CO2
Herein, catalytic fluoride (F-) is demonstrated to be a trigger for dehydrative immobilization of atmospheric pressure CO2, such that reaction of CO2 with β-amino alcohols derived from natural amino acids gives optically pure oxazolidinones in high yields. A synergistic combination of fluoride and organosilicon agents (e.g., Bu4NF + Ph3SiF or siloxanes) enhances the catalytic activity and functional group compatibility. This system lies at the interface between homogenous and heterogeneous catalysis, and may prove useful for the development of recoverable/reusable siloxane-based CO2 immobilization materials. This journal is
Takada, Yuki,Foo, Siong Wan,Yamazaki, Yusuke,Saito, Susumu
p. 50851 - 50857
(2015/02/19)

Novelty of immobilized enzymatic synthesis of 3-ethyl-1,3-oxazolidin-2-one using 2-aminoalcohol and dimethyl carbonate: Mechanism and kinetic modeling of consecutive reactions
Oxazolidinones are multifunctional compounds possessing diverse biological and pharmacological activity. Enzymatic synthesis of oxazolidin-2-one was studied using 2-aminoalochol and dimethyl carbonate and synthesis of 3-ethyl-1,3-oxazolidin-2-one was chosen as the model reaction using a variety of immobilized lipases; among which Candida antarctica lipase B (Novozyme 435) was the best catalyst. The reaction leads to the final product oxazolidin-2-one via methyl ethyl (2-hydroxyethyl) carbamate as the intermediate. The parameters affecting rate of reaction and the conversion of both steps were studied systematically and covered effects of agitation speed, solvent, catalyst loading and reaction temperature. A reaction mechanism was proposed wherein the coproduct methanol is generated in the first step leading to the formation of methyl ethyl (2-hydroxyethyl) carbamate as the intermediate which rearranges itself leading to the final products 3-ethyl-1,3-oxazolidin-2-one and methanol. The kinetic constant and activation energy were determined for each step of the reaction. The study was further extended to other 2-aminoalochols under optimized reaction conditions to prepare different oxazolidinones. This is a first report of its kind describing kinetics and mechanism of bimolecular consecutive enzyme catalyzed reactions.
Yadav, Ganapati D.,Pawar, Sandip V.
p. 62 - 69
(2014/11/08)

Novelty of immobilized enzymatic synthesis of 3-ethyl-1,3-oxazolidin-2-one using 2-aminoalcohol and dimethyl carbonate: Mechanism and kinetic modeling of consecutive reactions
Oxazolidinones are multifunctional compounds possessing diverse biological and pharmacological activity. Enzymatic synthesis of oxazolidin-2-one was studied using 2-aminoalochol and dimethyl carbonate and synthesis of 3-ethyl-1,3-oxazolidin-2-one was chosen as the model reaction using a variety of immobilized lipases; among which Candida antarctica lipase B (Novozyme 435) was the best catalyst. The reaction leads to the final product oxazolidin-2-one via methyl ethyl (2-hydroxyethyl) carbamate as the intermediate. The parameters affecting rate of reaction and the conversion of both steps were studied systematically and covered effects of agitation speed, solvent, catalyst loading and reaction temperature. A reaction mechanism was proposed wherein the coproduct methanol is generated in the first step leading to the formation of methyl ethyl (2-hydroxyethyl) carbamate as the intermediate which rearranges itself leading to the final products 3-ethyl-1,3-oxazolidin-2-one and methanol. The kinetic constant and activation energy were determined for each step of the reaction. The study was further extended to other 2-aminoalochols under optimized reaction conditions to prepare different oxazolidinones. This is a first report of its kind describing kinetics and mechanism of bimolecular consecutive enzyme catalyzed reactions.
Yadav, Ganapati D.,Pawar, Sandip V.
p. 62 - 69
(2014/12/10)

3-PYRIMIDIN-4-YL-OXAZOLIDIN-2-ONES AS INHIBITORS OF MUTANT IDH
The invention is directed to a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein R1-R6 are defined herein. The invention is also directed to compositions containing a compound of formula (I) and to the use of such compounds in the inhibition of mutant IDH proteins having a neomorphic activity. The invention is further directed to the use of a compound of formula (I) in the treatment of diseases or disorders associated with such mutant IDH proteins including, but not limited to, cell-proliferation disorders, such as cancer.
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Paragraph 0261; 0262

(2014/09/03)

3-PYRIMIDIN-4-YL-OXAZOLIDIN-2-ONES AS INHIBITORS OF MUTANT IDH
The invention is directed to a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein R1-R6 are defined herein. The invention is also directed to compositions containing a compound of formula (I) and to the use of such compounds in the inhibition of mutant IDH proteins having a neomorphic activity. The invention is further directed to the use of a compound of formual (I) in the treatment of diseases or disorders associated with such mutant IDH proteins including, but not limited to, cell-proliferation disorders, such as cancer
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Page/Page column 46-48

(2013/04/13)

Synthesis of some 2-Oxazolidinones in mild conditions
One step efficient protocol for the synthesis of 2-oxazolidinones in paste chemical medium is described under microwave activation with 80 % yield.
Bratulescu, George
experimental part
p. 929 - 930
(2011/12/15)

Copper-catalyzed intramolecular C-H amination
The amino-functionalization of tertiary, secondary and benzylic C-H bonds of tethered carbamates and sulfamates by iodosobenzene is catalyzed by Cu I-diimine complexes in moderate to good yield. Employing homochiral imine-Cucatalysts affords oxazolidinones and oxathiazinanes with modest enantioselectivity.
Barman, Dipti N.,Nicholas, Kenneth M.
supporting information; experimental part
p. 908 - 911
(2011/04/26)

N-tosyloxycarbamates as reagents in rhodium-catalyzed C-H amination reactions
Metal nitrenes for use in C-H insertion reactions were obtained from N-tosyloxycarbamates in the presence of an inorganic base and a rhodium(II) dimer complex catalyst. The C-H amination reaction proceeds smoothly, and the potassium tosylate that forms as a byproduct is easily removed by filtration or an aqueous workup. This new methodology allows the amination of ethereal, benzylic, tertiary, secondary, and even primary C-H bonds. The intramolecular reaction provides an interesting route to various substituted oxazolidinones, whereas the intermolecular reaction gives trichloroethoxycarbonyl-protected amines that can be isolated with moderate to excellent yields and that cleave easily to produce the corresponding free amine. The development, scope, and limitations of the reactions are discussed herein. Isotopic effects and the electronic nature of the transition state are used to discuss the mechanism of the reaction.
Huard, Kim,Lebel, Helene
supporting information; experimental part
p. 6222 - 6230
(2009/05/27)

A novel way to chiral 2-oxazolidinones: selenium-catalyzed cyclocarbonylation of 2-aminoethanols
Selenium-catalyzed cyclocarbonylation of 2-aminoethanols with CO under atmospheric pressure at 30 °C afforded 2-oxazolidinones in excellent yields without any other co-catalyst. The method was then applied to the syntheses of chiral 2-oxazolidinones and no racemization was detected.
Li, Peng,Yuan, Xiaohua,Wang, Shudong,Lu, Shiwei
p. 12419 - 12423
(2008/03/13)

Synthesis of 2-oxazolidinones by salen-Co-complexes catalyzed oxidative carbonylation of β-amino alcohols
2-Oxazolidinones are synthesized in high yield by oxidative carbonylation of β-amino alcohols using salen-Co(II)/NaI or salen-Co(III)-I as a catalyst and using CO as the carbonyl source. Studies of functional group compatibility using a series of substituted salen-Co(II) or salen-Co(III)-I complexes demonstrate a broad tolerance of functionality during the carbonylation reaction.
Liu, Jian-Ming,Peng, Xin-Gao,Liu, Jian-Hua,Zheng, Shu-Zhan,Sun, Wei,Xia, Chun-Gu
p. 929 - 932
(2008/02/04)

Efficient synthesis of oxazolidin-2-one via (chitosan-Schiff base)cobalt(II)-catalyzed oxidative carbonylation of 2-aminoalkan-1-ols
The (chitosan-Schiff base)cobalt(II) complex was found to be an efficient catalyst for the oxidative carbonylation (CO/O2) of 2-aminoalkan-1-ols 1 to give oxazolidin-2-ones 2, in the presence of NaI. The effects of promoters, temperature, solvents, and other reaction conditions were investigated in this study.
Liu, Jianming,Sun, Wei,Zheng, Shuzhan,Xia, Chungu
p. 1593 - 1598
(2008/02/09)

Silver-catalyzed intermolecular amination of C-H groups
(Chemical Equation Presented) Teamwork: The dinuclear silver complex [Ag2(OTf)2(bp)2] (OTf = trifluoromethane- sulfonate, bp = bathophenanthroline) catalyzes the intermolecular amination of saturated C-H bonds by using Phl=NNs (Ns = p-nitrosulfonyl) as the nitrene precursor (see scheme). Preliminary investigations suggest that the dinuclear structural motif is crucial to catalytic performance.
Li, Zigang,Capretto,Rahaman,He, Chuan
p. 5184 - 5186
(2008/03/18)

Novel α-aminophosphonic acids. Design, characterization, and biological activity
Novel α-aminophosphonic acids are synthesized reacting 1,3-oxazolidin-2-one derivatives with formaldehyde and phosphorus trichloride. Treatment of N-(phosphonomethyl)oxazolidinones with aqueous NaOH gave the expected α-aminophosphonic acids. The oxidation
Naydenova, Emilia,Topashka-Ancheva, Margarita,Todorov, Petar,Yordanova,Troev, Kolio
p. 2190 - 2196
(2007/10/03)

N-tosyloxycarbamates as a source of metal nitrenes: Rhodium-catalyzed C-H insertion and aziridination reactions
The rhodium-catalyzed decomposition of N-tosyloxycarbamates to generate metal nitrenes which undergo intramolecular C-H insertion or aziridination reaction is described. Aliphatic N-tosyloxycarbamates produce oxazolidinones with high yields and stereospecificity through insertion in benzylic, tertiary, and secondary C-H bonds. Intramolecular aziridination occurs with allylic N-tosyloxycarbamates to produce aziridines as single diastereomers. The reaction proceeds at room temperature using a rhodium catalyst and an excess of potassium carbonate and does not require the use of strong oxidant, such as hypervalent iodine reagents. A rhodium nitrene species is presumably involved, as both reactions are stereospecific. Copyright
Lebel, Helene,Huard, Kim,Lectard, Sylvain
p. 14198 - 14199
(2007/10/03)

A silver-catalyzed intramolecular amidation of saturated C-H bonds
Opportunities with silver: A dinuclear silver(I) compound was found to efficiently catalyze the intramolecular amidation of saturated C-H bonds of carbamates and sulfamates (see scheme). This highly regioselective, stereospecific reaction offers a practical method for the construction of cyclic nitrogen-containing organic molecules.
Cui, Yong,He, Chuan
p. 4210 - 4212
(2007/10/03)

N-Phosphoryl oxazolidinones as effective phosphorylating agents
A number of N-phosphoryl oxazolidinones have been prepared and evaluated, the best being 5,5-diphenyl oxazolidinones, the utility of which was demonstrated in the phosphorylation of a number of representative primary, secondary, tertiary, and phenolic alcohols.
Jones, Simon,Smanmoo, Chaiwat
p. 1585 - 1588
(2007/10/03)

N-acyl-5,5-dimethyloxazolidin-2-ones as latent aldehyde equivalents
A study of the properties of N-hydrocinnamoyl- derivatives of 5,5-dimethyloxazolidin-2-one, 4,4-dimethyloxazolidin-2-one and oxazolidin-2-one upon hydride reduction with DIBAL-H demonstrates that the 5,5-dimethyl-group is essential for inhibition of endocyclic nucleophilic attack. For instance, treatment of N-hydrocinnamoyl-5,5-dimethyl-oxazolidin-2-one with DIBAL-H results in the selective formation of the stable N-1′-hydroxyalkyl derivative which may be regarded as a masked hydrocinnamaldehyde equivalent, as treatment under basic conditions affords the parent aldehyde in excellent yield. Treatment of N-hydrocinnamoyl-4,4-dimethyloxazolidin-2-one with DIBAL-H under identical conditions affords a complex mixture of products, including the formate ester product of endocyclic cleavage. As an alternate strategy, DIBAL-H reduction of straight chain and branched N-acyl-5,5-dimethyloxazolidin-2-one derivatives, followed by a Horner-Wadsworth-Emmons reaction affords α,β-unsaturated esters in good yields. Branching α- to the exocyclic carbonyl in N-acyl-oxazolidinones inhibits DIBAL-H reduction, but this can be overcome by precomplexation with ZnCl2, with subsequent fragmentation generating either the corresponding aldehyde or α,β-unsaturated esters. The addition of ZnCl2 has been shown to increase the diastereoselectivity observed in Wadsworth-Horner-Emmons reactions of lithiated phosphonates.
Bach, Jordi,Blachere, Cecile,Bull, Steven D.,Davies, Stephen G.,Nicholson, Rebecca L.,Price, Paul D.,Sanganee, Hitesh J.,Smith, Andrew D.
p. 2001 - 2010
(2007/10/03)

A Rh-catalyzed C-H insertion reaction for the oxidative conversion of carbamates to oxazolidinones
Selective intramolecular alkane oxidations: an RhII carboxylate catalyzed C-H amination reaction facilitates the preparation of 1,2-amino alcohols from primary carbamates. The reaction is stereospecific, providing access to chiral α-branched amines from optically pure starting with no loss in enantiomeric excess (see scheme).
Espino, Christine G.,Du Bois
p. 598 - 600
(2007/10/03)

Computational, ReactIR-, and NMR-spectroscopic investigations on the chiral formyl anion equivalent N-(α-lithiomethylthiomethyl)-4-isopropyl-5,5-diphenyloxazolidin-2-one and related compounds
The 4-isopropyl-3-methylthiomethyl-5,5-diphenyloxazolidin-2-one is readily lithiated in THF on the exocyclic CH2 group (1 → 2) to give a synthetically useful chiral nucleophilic formylating reagent. We have now studied the lithiation reaction b
Gaul, Christoph,Arvidsson, Per I.,Bauer, Walter,Gawley, Robert E.,Seebach, Dieter
p. 4117 - 4125
(2007/10/03)

Efficient desymmetrization of meso-cis-1,2-cyclohexanedimethanol with differentiation between diastereotopic and enentiotopic C-H bonds by (-)- sparteine-mediated deprotonation
The deprotonation of a dicarbamate prepared from cis-1,2- cyclohexanedimethanol by sec-butyllithium/(-)-sparteine proceeds with efficient selection between the enantiotopic branches and their diastereotopic protons with high preference for the pro-S proto
Van Bebber, Jan,Ahrens, Hartmut,Froehlich, Roland,Hoppe, Dieter
p. 1905 - 1916
(2007/10/03)

Synthesis of 2-Oxo-Oxazolidines and -Thiazolidines from the Corresponding 2-Thioxo Compounds
2-Thioxo-oxazolidines and -thiazolidines are easily converted by reaction with an epoxide under acidic conditions into the corresponding 2-oxo compounds.
Calo, Vinzenzo,Nacci, Angelo,Volpe, Angela
p. 283 - 286
(2007/10/03)

2-(2-substituted pyrrolidin-4-yl) thio-carbapenem derivatives
The present invention relates to 2-(2-substituted pyrrolidin-4-yl)-thio-carbapenem derivatives and pharmaceutically acceptable salts thereof, to a process for preparing the derivatives, an intermediate compound for preparing the derivatives, an antibacterial composition containing the derivatives, and use of the derivatives as an antibacterial agent.
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(2008/06/13)

Highly stereocontrolled synthesis of the 1β-methylcarbapenem key intermediate by the Reformatsky reaction of 3-(2-bromopropionyl)-2-oxazolidone derivatives with a 4-acetoxy-2-azetidinone
The key synthetic intermediate (4) of 1β-methylcarbapenems (1~3) was efficiently synthesized by employing highly stereocontrolled Reformatsky reaction (C4-alkylation) of 3-(2-bromopropionyl)-2-oxazolidone derivatives (6) with (3R,4R)-4-acetoxy-3-[(R)-1-(t-butyldimethylsilyloxy)ethyl]-2-azetidino ne (5) in the presence of zinc dust followed by removal of 2-oxazolidone moieties. The best diastereoselectivity (β:α = 95:5) could be realized by uses of sterically crowded achiral 2-oxazolidone derivatives such as 4,4-dimethyl-, 4,4,5,5-tetramethyl, and 4,4-dibutyl-5,5-pentamethylene-2-oxazolidone and higher reaction temperatures (refluxing tetrahydrofran). The remarkable diastereoselectivities observed for the Reformatsky reactions could be explained by means of the weakly chelating transition state models.
Ito,Sasaki,Tamoto,Sunagawa,Terashima
p. 2801 - 2820
(2007/10/02)

PREPARATION OF CYCLIC CARBONATES AND 2-OXAZOLIDONES USING DI-2-PYRIDYL CARBONATE
Cyclic carbonates and 2-oxazolidones are conveniently prepared in high yields by the reaction of diols and β-amino alcohols with di-2-pyridyl carbonate.It is of synthetic significance that the formation of cyclic carbonates in refluxing toluene occurs under essentially neutral conditions.
Kim, Sunggak,Ko, Young Kwan
p. 1625 - 1630
(2007/10/02)

RING ENLARGING DIPOLAR CYCLOADDITIONS OF CHLOROSULFONYLISOCYANATE TO EPOXIDES
Chlorosulfonyl isocyanate cycloadds to epoxides at -78 deg C to give 1,3-dioxolan-2-ones and/or 2-oxazolidones in moderate yields after aqueous work-up.
Lorincz, Tibor,Erden, Ihsan,Naeder, Reinhard,Meijere, Armin de
p. 123 - 130
(2007/10/02)

Cyclization of (2-hydroxyethyl)urea derivatives to give 3-nitroso-2-oxazolidinones under usual nitrosation conditions
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Miyahara,Nakadate,Kamiya
p. 497 - 502
(2007/10/02)

2,5-Dilithiation of N-Protected Imidazoles. Syntheses of 2,5-Disubstituted Derivatives of 1-Methoxymethyl-, 1-Triphenylmethyl-, and 1-(N,N-Dimethylsulphonamido)-imidazole
The conditions previously established for the dilithiation of 1-methylimidazole are shown to be applicable to 1-methoxymethyl- and 1-triphenylmethyl-imidazole allowing good-yielding syntheses of 1,2,5-trisubstituted imidazole derivatives.The suitability of the 1-substituted (and of other groups) for the N-protection of imidazoles in dilithiation experiments is discussed and the use of the N,N-dimethylsulphamoyl protecting group is proposed. 1-Sulphamoylimidazole undergoes mono- and 2,5-di-lithiation quantitatively at low temperatures and in short reaction times.The results of work-up of the 2,5-dilithio intermediate with 1 mol equiv. of iodomethane or dimethyl sulphate indicate selectivity in favour of reaction at the 5-position.
Chadwick, Derek J.,Ngochindo, Raphael I.
p. 481 - 486
(2007/10/02)

Method of moisturizing the skin with carbamide acid esters
Skin-care, skin-protection, and skin-cleaning agent compositions containing as a skin-moisturizing agent at least one substituted carbamide acid ester, said substituted carbamide acid ester having the formula STR1 wherein R1 is a member selecte
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(2008/06/13)

3-Chloro-2-oxazolidinones
Antibacterially effective 3-chloro-2-oxazolidinones are prepared by chlorination of an appropriate 2-oxazolidinone either with elemental chlorine in an aqueous medium or with a mono-, di- or trichloroisocyanuric acid (cyanuric chloride) in an inert organi
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(2008/06/13)