2709-56-0Relevant articles and documents
A hydrochloric acid flupentixol preparation method
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Paragraph 0032-0037, (2020/02/08)
The invention provides a preparation method of flupentixol dihydrochloride, which comprises the following steps: reacting and dehydrating 10-hydroxy-10-(3-dimethylaminopropyl)-2-trifluoromethyl thioxanthene and sulfoxide chloride or acetic anhydride to prepare high-content Z-type 10-[3-(EZ)-dimethylaminopropyl]-2-trifluoromethyl thioxanthene, reacting with N-hydroxyethyl piperazidine to prepare flupentixol base, and finally, introducing sufficient hydrochloric acid gas into the flupentixol base to prepare the high-content Z-type flupentixol dihydrochloride. The method has the advantages of fewer steps, high yield and high product purity, is simple to operate, and does not use any extremely toxic substance to pollute the environment. The Z-type flupentixol dihydrochloride content in the flupentixol dihydrochloride prepared by the method is 42-52%, and conforms to the quality standard specification for flupentixol dihydrochloride in European Pharmacopoeia.
Preparation method of medicinal flupentixol dihydrochloride
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Paragraph 0073; 0074, (2016/10/07)
The invention discloses a preparation method of medicinal flupentixol dihydrochloride. The preparation method comprises that 1), 2-trifluoromethyl-9-allylthioxanthenol, methyl tertiary-butyl ether and hydrochloric acid are uniformly mixed and undergo a reaction to produce 2-trifluoromethyl-9-(2-propenylidene)thiaxanthene, 2), 2-trifluoromethyl-9-(2-propenylidene)thiaxanthene and N-(2-hydroxyethyl)piperazine undergo an addition reaction in an organic solution at a reaction temperature of 100-150 DEG C for 5-20h to produce 9-[3-(4-ethoxy-1-piperazinyl)propylidene]-2-trifluoromethylthiaxanthene, 3), a flupentixol dihydrochloride crude product is prepared, and 4), the flupentixol dihydrochloride crude product is purified. The preparation method has simple processes and a short technical route, produces less by-products in the reaction, has a high yield, realizes high product purity and is suitable for industrial production.
PROCESS FOR THE PREPARATION OF Z-FLUPENTIXOL
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Page/Page column 10-11, (2010/02/11)
The present invention relates to a process for the separation of flupentixol isomers, particularly, a process for the preparation of Z-flupentixol and the decanoate ester and novel synthetic intermediates thereof.