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CAS

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27225-00-9

[2,7]Naphthyridin-1-ylamine is a chemical compound that belongs to the naphthyridine family, which are polycyclic aromatic compounds containing a naphthyridine moiety. It is characterized by the fusion of two benzene rings with a pyridine ring and features an amine group with a basic nitrogen atom and a lone pair. Naphthyridines, in general, are utilized in the production of pharmaceutical drugs and display a variety of biological activities, although [2,7]Naphthyridin-1-ylamine itself is not widely recognized or commonly used due to its specific characteristics and properties.

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  • 27225-00-9 Structure

  • Basic information

    1. Product Name: [2,7]NAPHTHYRIDIN-1-YLAMINE
    2. Synonyms: [2,7]NAPHTHYRIDIN-1-YLAMINE;2,7-Naphthyridin-1-amine;1-Amino-2,7-naphthyridine
    3. CAS NO:27225-00-9
    4. Molecular Formula: C8H7N3
    5. Molecular Weight: 145.16
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 27225-00-9.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 363.672 °C at 760 mmHg
    3. Flash Point: 201.242 °C
    4. Appearance: /
    5. Density: 1.293 g/cm3
    6. Vapor Pressure: 0mmHg at 25°C
    7. Refractive Index: 1.724
    8. Storage Temp.: 2-8°C(protect from light)
    9. Solubility: N/A
    10. PKA: 5.54±0.30(Predicted)
    11. CAS DataBase Reference: [2,7]NAPHTHYRIDIN-1-YLAMINE(CAS DataBase Reference)
    12. NIST Chemistry Reference: [2,7]NAPHTHYRIDIN-1-YLAMINE(27225-00-9)
    13. EPA Substance Registry System: [2,7]NAPHTHYRIDIN-1-YLAMINE(27225-00-9)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 27225-00-9(Hazardous Substances Data)

27225-00-9 Usage

Uses

Given the provided materials, there are no specific applications mentioned for [2,7]Naphthyridin-1-ylamine. However, since it is part of the naphthyridine family, which is used in the production of pharmaceutical drugs, it can be inferred that [2,7]Naphthyridin-1-ylamine may have potential uses in the pharmaceutical industry.
Used in Pharmaceutical Industry:
[2,7]Naphthyridin-1-ylamine is used as a chemical intermediate for the synthesis of pharmaceutical drugs due to its belonging to the naphthyridine family, which is known for its involvement in drug production and exhibiting biological activities. The specific applications and reasons for its use in drug development would require further research and validation.

Check Digit Verification of cas no

The CAS Registry Mumber 27225-00-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,7,2,2 and 5 respectively; the second part has 2 digits, 0 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 27225-00:
(7*2)+(6*7)+(5*2)+(4*2)+(3*5)+(2*0)+(1*0)=89
89 % 10 = 9
So 27225-00-9 is a valid CAS Registry Number.
InChI:InChI=1/C8H7N3/c9-8-7-5-10-3-1-6(7)2-4-11-8/h1-5H,(H2,9,11)

27225-00-9Relevant articles and documents

7-AZAINDOLE-2,7-NAPHTHYRIDINE DERIVATIVE FOR THE TREATMENT OF TUMOURS

-

Paragraph 0166, (2015/09/28)

The compound 4-(2-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-2,7-naphthyridin-1-ylamine and pharmaceutically usable salts and/or tautomers thereof. The use of this compound for the treatment of tumours, tumour growth, tumour metastases and/or AIDS.

The amination of halogeno-2,7- and 1,8-naphthyridines

Haak, H. J. W. van den,Plas, H. C. van der

, p. 235 - 238 (2007/10/02)

The conversion of 1-halogeno-2,7-naphthyridines into the corresponding 1-amino compounds with KNH2/NH3, is shown, by the use of deuterated starting compounds, to proceed via an SN(AE)ipso substitution and not via an SN(AE)tele mechanism, even though convincing evidence for the formation of tele ?-adduct, 8-amino-1-halogeno-dihydro-2,7-naphthyridine, was obtained.Using the same methods, it is shown that the conversion of 2-bromo-1,8-naphthyridine into 2-amino-1,8-naphthyridine proceds, to the extent of 40percent via an odd SN(AE)tele pathway.

Amination of 2,6- and 2,7-Naphtyridine. An NMR Study on ?-Adducts of Heterocyclic Systems with Amide Ions

Haak, Henk J. W. van den,Plas, Henk C. van der,Veldhuizen, Beb van

, p. 1349 - 1352 (2007/10/02)

A facile synthesis of 2,6-naphtyridine is described.Both 2,6- and 2,7-naphtyridine undergo with potassium amide under kinetically and thermodynamically controlled conditions ?-adduct formation at position 1.Chichibabin amination of 2,6-naphtyridine yields 1-amino-2,6-naphtyridine in 54percent yield.

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