272769-49-0

Basic information

• Product Name: 2-(1-Propyl-4-piperidinyl)-1H-benzimidazole-7-carboxamide
• Synonyms: 2-(1-Propyl-4-piperidinyl)-1H-benzimidazole-7-carboxamide;1H-BenziMidazole-7-carboxaMide, 2-(1-propyl-4-piperidinyl)-;2-(1-Propylpiperidin-4-yl)-1H-benzo[d]iMidazole-7-carboxaMide;2-(1-Propyl-4-piperidinyl)-1H-benzimidazole-4-carboxamide
• CAS NO: 272769-49-0
• Molecular Formula: C16H22N4O
• Molecular Weight: 286.377
• Mol File: 272769-49-0.mol

Chemical Properties

• Boiling Point: 573.215°C at 760 mmHg
• Flash Point: 300.47°C
• Appearance: /
• Density: 1.193g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.62
• PKA: 17.82±0.30(Predicted)
• CAS DataBase Reference: 2-(1-Propyl-4-piperidinyl)-1H-benzimidazole-7-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(1-Propyl-4-piperidinyl)-1H-benzimidazole-7-carboxamide(272769-49-0)
• EPA Substance Registry System: 2-(1-Propyl-4-piperidinyl)-1H-benzimidazole-7-carboxamide(272769-49-0)

Safety Data

• Hazardous Substances Data: 272769-49-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-(1-propyl-4-piperidinyl)-1H-benzimidazole-7-carboxamide is used as a neuroprotective agent for its potential in treating neurodegenerative diseases such as Alzheimer's and Parkinson's disease. It promotes the survival of newborn neurons in the brain, which could have significant implications for the treatment of various neurological disorders.
Used in Neurodegenerative Disease Research:
2-(1-propyl-4-piperidinyl)-1H-benzimidazole-7-carboxamide is used as a research compound to explore its therapeutic potential in various neurodegenerative conditions. Its mechanism of action, which involves increasing NAD levels and reducing DNA damage, is of particular interest in enhancing neuronal survival and potentially slowing the progression of these diseases.

InChI:InChI=1/C16H22N4O/c1-2-8-20-9-6-11(7-10-20)16-18-13-5-3-4-12(15(17)21)14(13)19-16/h3-5,11H,2,6-10H2,1H3,(H2,17,21)(H,18,19)

Upstream product

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Relevant articles and documents

Process development for ABT-472, a benzimidazole PARP inhibitor

A nine-step convergent process was developed for the synthesis of ABT-472, a benzimidazole PARP inhibitor. The identity and origin of several impurities were determined, and the process was modified to reduce or eliminate these impurities. A number of safety and control issues were investigated. The original synthesis was shortened to 9 steps and streamlined while maintaining a convergent strategy. A stable salt was selected, and control of the API solid form was established. The process was successfully scaled up to provide 8.5 kg of final product of >99% purity in 33% yield over 9 steps.

Substituted benzimidazoles and their use as parp inhibitors

Compounds of the formula Ia or IB where A is a saturated or monounsaturated heterocyclic, 4- to 8-membered ring which contains one or two nitrogen atoms, and their tautomeric forms, possible enantiomeric and diastereomeric forms, their prodrugs and possible physiologically tolerated salts are useful as inhibitors of the enzyme poly(ADP-ribose)polymerase.