284477-00-5

Basic information

• Product Name: 2-(quinolin-2-yl)acetic acid
• Synonyms: 2-(quinolin-2-yl)acetic acid;2-Quinolineacetic acid
• CAS NO: 284477-00-5
• Molecular Formula: C₁₁H₉NO₂
• Molecular Weight: 187
• Mol File: 284477-00-5.mol

Chemical Properties

• Boiling Point: 365.1 °C at 760 mmHg
• Flash Point: 174.6 °C
• Appearance: /
• Density: 1.297
• PKA: 1.30±0.30(Predicted)
• CAS DataBase Reference: 2-(quinolin-2-yl)acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(quinolin-2-yl)acetic acid(284477-00-5)
• EPA Substance Registry System: 2-(quinolin-2-yl)acetic acid(284477-00-5)

Safety Data

• Hazardous Substances Data: 284477-00-5(Hazardous Substances Data)

Usage

Uses

Used in Oncology:
2-(Quinolin-2-yl)acetic acid is used as an anticancer agent for its ability to inhibit the growth of cancer cells. Its mechanism of action involves the inhibition of dihydrofolate reductase, a key enzyme in the synthesis of nucleic acids, which is crucial for the proliferation of rapidly dividing cells such as cancer cells.
Used in Parasitology:
In the field of parasitology, 2-(Quinolin-2-yl)acetic acid is used as an antimalarial agent. It has been investigated for its potential to inhibit the growth of the parasitic protozoan Plasmodium falciparum, which is responsible for causing malaria.
Used in Neuroprotection Research:
2-(Quinolin-2-yl)acetic acid is used as a subject of study in neuroprotection research due to its potential neuroprotective effects. It is being explored for its role in the pathology of neurodegenerative diseases such as Alzheimer's and Huntington's, where its modulation could potentially slow disease progression or provide therapeutic benefits.
Used in Neuroinflammation and Neurological Disorders Research:
In the context of neuroinflammation and neurological disorders, 2-(Quinolin-2-yl)acetic acid is used as a research tool to understand its association with various conditions. Its role in these areas is being investigated to uncover potential therapeutic targets for the treatment of related disorders.
Each of these applications underscores the versatility and potential impact of 2-(Quinolin-2-yl)acetic acid in different areas of medical and biological research, highlighting its importance in the development of new treatments and therapies.

Upstream product

• 1011-47-8 1-quinolin-2-yl-ethanone 
• 14068-28-1 2-(quinolin-2-yl)acetonitrile 
• 50342-01-3 quinolin-2-ylcarbonyl chloride 
• 5632-15-5 quinolin-2-ylmethylbromide 
• 1613-37-2 Quinoline N-oxide 
• 69582-84-9 methyl 2-(1,2-dihydroquinolin-2-ylidene)-3-oxobutanoate 
• 52249-48-6 quinoline-2-acetic acid methyl ester 
• 613-53-6 2-tribromomethyl-quinoline 

Relevant articles and documents

Synthesis, anticonvulsant activity, and neuropathic pain-attenuating activity of N-benzyl 2-amino-2-(hetero)aromatic acetamides

N-Benzyl 2-acetamido-2-substituted acetamides, where the 2-substituent is a (hetero)aromatic moiety, are potent anticonvulsants. We report the synthesis and whole animal pharmacological evaluation of 16 analogues where the terminal 2-acetyl group was removed to give the corresponding primary amino acid derivatives (PAADs). Conversion to the PAAD structure led to a substantial drop in seizure protection in animal tests, demonstrating the importance of the N-acetyl moiety for anticonvulsant activity. However, several of the PAADs displayed notable pain-attenuating activities in a mouse model.