289725-89-9

Basic information

• Product Name: 1,3-DIPHENYL-4-ETHYL-5-(4-METHOXYPHENYL)-1H-PYRAZOLE
• Synonyms: 1,3-DIPHENYL-4-ETHYL-5-(4-METHOXYPHENYL)-1H-PYRAZOLE
• CAS NO: 289725-89-9
• Molecular Formula: C₂₄H₂₂N₂O
• Molecular Weight: 354.44
• Product Categories: pharmacetical
• Mol File: 289725-89-9.mol

Chemical Properties

• Boiling Point: 536.4°Cat760mmHg
• Flash Point: 278.2°C
• Appearance: /
• Density: 1.09g/cm³
• Vapor Pressure: 4.88E-11mmHg at 25°C
• Refractive Index: 1.598
• CAS DataBase Reference: 1,3-DIPHENYL-4-ETHYL-5-(4-METHOXYPHENYL)-1H-PYRAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-DIPHENYL-4-ETHYL-5-(4-METHOXYPHENYL)-1H-PYRAZOLE(289725-89-9)
• EPA Substance Registry System: 1,3-DIPHENYL-4-ETHYL-5-(4-METHOXYPHENYL)-1H-PYRAZOLE(289725-89-9)

Safety Data

• Hazardous Substances Data: 289725-89-9(Hazardous Substances Data)

Usage

Chemical structure

A heterocyclic compound with a pyrazole ring structure.

Composition

Consists of three phenyl groups, an ethyl group, and a methoxyphenyl group.

Potential drug candidate

Due to its diverse biological activities.

Biological activities

Analgesic, antipyretic, and anti-inflammatory properties.

Applications

Studied for treating pain, fever, and inflammation.

Neuroprotective agent

Has shown potential as a neuroprotective agent.

Implications

May have implications for the treatment of neurological disorders.
Please note that this list is based on the provided material and may not be exhaustive. Further research and analysis may reveal additional properties and applications of DMPP.

InChI:InChI=1/C24H22N2O/c1-3-22-23(18-10-6-4-7-11-18)25-26(20-12-8-5-9-13-20)24(22)19-14-16-21(27-2)17-15-19/h4-17H,3H2,1-2H3

Upstream product

• 871110-29-1 4-ethyl-5-(4'-methoxyphenyl)-3-(methylthio)-1-phenyl-1H-pyrazole 
• 100-63-0 phenylhydrazine 
• 22252-15-9 trans-4-methoxychalcone 
• 2574-33-6 5-(4-methoxyphenyl)-1,3-diphenyl-4,5-dihydro-1H-pyrazole 
• 59-88-1 phenylhydrazine hydrochloride 
• 5874-09-9 methyl (4-methoxyphenyl)carbodithioate 
• 4160-51-4 1-(4-methoxyphenyl)-1-butanone 

Relevant articles and documents

Cyclocondensation of arylhydrazines with 1,3-bis(het)arylmonothio-1,3- diketones and 1,3-Bis(het)aryl-3-(methylthio)-2-propenones: Synthesis of 1-Aryl-3,5-bis(het)arylpyrazoles with complementary regioselectivity

Two efficient highly regioselective routes for the synthesis of unsymmetrically substituted 1-aryl-3,5-bis(het)arylpyrazoles with complementary regioselectivity starting from active methylene ketones have been reported. In the first protocol, the newly synthesized 1,3-bis(het)aryl-monothio-1,3-diketone precursors (prepared by condensation of active methylene ketones with het(aryl) dithioesters in the presence of sodium hydride) were reacted with arylhydrazines in refluxing ethanol under neutral conditions, furnishing 1-aryl-3,5-bis(het)arylpyrazoles 7, in which the het(aryl) moiety attached to the thiocarbonyl group of monothio-1,3-diketones is installed at the 3-position. In the second method, the corresponding 3-(methylthio)-1,3-bis(het)aryl-2- propenones (prepared in situ by base-induced alkylation of 1,3- monothiodiketones) were condensed with arylhydrazines in the presence of potassium tert-butoxide in refluxing tert-butyl alcohol, yielding 1-aryl-3,5-bis(het)arylpyrazoles 9 with complementary regioselectivity (method A). The efficiency of this protocol was further improved by developing a one-pot, three-component procedure for the synthesis of pyrazoles 9, directly from active methylene ketones, by reacting in situ generated 3-(methylthio)-1,3-bis(het)aryl-2-propenones with arylhydrazines in the presence of sodium hydride (instead of potassium tert-butoxide as base). The structures and regiochemistry of newly synthesized pyrazoles were confirmed from their spectral and analytical data along with X-ray crystallographic data of three pairs of regioisomers.

Regioselective synthesis of 1-aryl-3,4-substituted/annulated-5-(methylthio) pyrazoles and 1-aryl-3-(methylthio)-4,5-substituted/annulated pyrazoles

Highly efficient and regioselective synthesis of 1-aryl-3,4-substituted/ annulated-5-(methylthio)-pyrazoles and 1-aryl-3-(methylthio)-4,5-substituted/ annulated pyrazoles has been reported via cyclocondensation of arylhydrazines with either α-oxoketene dithioacetals or β-oxodithioesters.

Regioselective synthesis of 1,3,5-triaryl-4-alkylpyrazoles: novel ligands for the estrogen receptor.

[reaction: see structure] A regioselective synthesis of 4-alkyl-1,3,5-triarylpyrazoles has been developed for the preparation of unsymmetrically substituted systems of interest as ligands for the estrogen receptor.