4160-51-4

Basic information

• Product Name: 4'-Methoxybutyrophenone
• Synonyms: 4'-METHOXYBUTYROPHENONE, TECH., 93%;4-Methoxyphenylpropyl ketone;4'-Methoxybutyrophenone,93%,tech.;Butyrophenone, 4'-methoxy- (8CI);4'-METHOXYBUTYROPHENONE;4-METHOXYBUTYROPHENONE;1-(4-METHOXYPHENYL)-1-BUTANONE;1-(4-METHOXYPHENYL)BUTAN-1-ONE
• CAS NO: 4160-51-4
• Molecular Formula: C₁₁H₁₄O₂
• Molecular Weight: 178.23
• EINECS: 223-995-5
• Product Categories: Miscellaneous
• Mol File: 4160-51-4.mol
• Article Data: 64

Chemical Properties

• Melting Point: 22 °C
• Boiling Point: 124-128 °C (4 mmHg)
• Flash Point: 124-128°C/4mm
• Appearance: white crystal
• Density: 1.0292 (rough estimate)
• Refractive Index: 1.5378-1.5398
• BRN: 908286
• CAS DataBase Reference: 4'-Methoxybutyrophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 4'-Methoxybutyrophenone(4160-51-4)
• EPA Substance Registry System: 4'-Methoxybutyrophenone(4160-51-4)

Safety Data

• Hazard Codes: Xi
• Safety Statements: 24/25
• HazardClass: IRRITANT
• Hazardous Substances Data: 4160-51-4(Hazardous Substances Data)

Usage

Chemical Properties

CLEAR YELLOW LIQUID

Upstream product

• 100-09-4 4-methoxybenzoic acid 
• 107-92-6 butyric acid 
• 69638-92-2 1,2-butyrideneacetate 
• 100-66-3 methoxybenzene 
• 93-04-9 2-Methoxynaphthalene 
• 141-75-3 butyryl chloride 
• 106-31-0 butanoic acid anhydride 
• 98-86-2 acetophenone 
• 22135-50-8 1-(4-(methoxy)phenyl)butan-1-ol 
• 1415455-15-0 C₁₃H₁₈O₃ 
• 72824-04-5 2-Allyl-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 123-11-5 4-methoxy-benzaldehyde 
• 109480-78-6 N-methoxy-N-methylbutanamide 
• 13139-86-1 4-methoxyphenyl magnesium bromide 

Downstream Products

• 31254-25-8 S-<3-(p-Methoxyphenyl)hexen-(2)-yl>isothiuroniumacetat 
• 68432-09-7 4-ethyl-5-(4-methoxy-phenyl)-4,5-dihydro-isoxazol-3-ylamine 
• 18272-84-9 4-n-butylanisole 
• 31254-22-5 3-Hydroxy-3-(p-methoxyphenyl)-1-hexen 
• 172988-64-6 ethyl 5-(4-methoxyphenyl)-4-ethyl-2-methyl-3,5-dioxopentanoate 
• 306972-70-3 Dimethyl (4R,5R)-2-(4-methoxyphenyl)-2-propyl-1,3-dioxolane-4,5-dicarboxylate 
• 71526-44-8 1,3-bis(4-methoxyphenyl)-2-ethyl-propane-1,3-dione 
• 97060-29-2 1-(4-methoxyphenyl)-but-2-en-1-one 
• 1032174-10-9 1-(4-methoxy-3-nitrophenyl)-butan-1-one 
• 120553-85-7 (E)-3-(4-Methoxyphenyl)-2-hexenal 
• 1263313-65-0 1-(4-chloro-benzenesulfonyl)-6-methoxy-3-propyl-1H-indole 
• 1263313-70-7 C₁₈H₁₈ClNO₃S 
• 1263313-25-2 N-(2-butyryl-5-methoxy-phenyl)-4-chloro-benzenesulfonamide 
• 423115-90-6 1-(4-methoxyphenyl)butanone oxime 

Relevant articles and documents

Rh-Catalyzed Coupling of Aldehydes with Allylboronates Enables Facile Access to Ketones

We present herein a novel strategy for the preparation of ketones from aldehydes and allylic boronic esters. This reaction involves the allylation of aldehydes with allylic boronic esters and the Rh-catalyzed chain-walking of homoallylic alcohols. The key to this successful development is the protodeboronation of alkenyl borylether intermediate via a tetravalent borate anion species in the presence of KHF2 and MeOH. This approach features mild reaction conditions, broad substrate scope, and excellent functional group tolerance. Mechanistic studies also supported that the tandem allylation and chain-walking process were involved.

Iron-Catalyzed C-C Single-Bond Cleavage of Alcohols

An iron-catalyzed deconstruction/hydrogenation reaction of alcohols through C-C bond cleavage is developed through photocatalysis, to produce ketones or aldehydes as the products. Tertiary, secondary, and primary alcohols bearing a wide range of substituents are suitable substrates. Complex natural alcohols can also perform the transformation selectively. A investigation of the mechanism reveals a procedure that involves chlorine radical improved O-H homolysis, with the assistance of 2,4,6-collidine.

Acylation of aryl halides and α-bromo acetates with aldehydes enabled by nickel/tbadt cocatalysis

In this protocol aryl halides and α-bromo acetates are efficiently cross-coupled with an array of (hetero)aromatic and aliphatic aldehydes under the cooperative catalysis of nickel and tetrabutylammonium decatungstate as a hydrogen-atom-transfer photocatalyst. This method provides a concise approach to a variety of ketones with high compatibility of various functional groups.