29027-20-1

Basic information

• Product Name: 3-Chloro-5-methylaniline
• Synonyms: 3-Amino-5-chlorotoluene;3-Chloro-5-methylaniline;3-chloro-5-MethylbenzenaMine;m-Toluidine, 5-chloro-
• CAS NO: 29027-20-1
• Molecular Formula: C₇H₈ClN
• Molecular Weight: 142
• EINECS: 1592732-453-0
• Mol File: 29027-20-1.mol

Chemical Properties

• Boiling Point: 248.6±20.0℃ (760 Torr)
• Flash Point: 104.1±21.8℃
• Appearance: /Solid
• Density: 1.180±0.06 g/cm3 (20 ºC 760 Torr)
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• PKA: 3.66±0.10(Predicted)
• Sensitive: Light Sensitive
• CAS DataBase Reference: 3-Chloro-5-methylaniline(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Chloro-5-methylaniline(29027-20-1)
• EPA Substance Registry System: 3-Chloro-5-methylaniline(29027-20-1)

Safety Data

• HazardClass: 6.1
• Hazardous Substances Data: 29027-20-1(Hazardous Substances Data)

Usage

Uses

Used in Chemical Synthesis Industry:
3-Chloro-5-methylaniline is used as a key intermediate in the synthesis of various industrial chemicals. Its unique structure allows for versatile chemical reactions, making it a valuable component in the production of dyes, pigments, and other specialty chemicals.
Used in Pharmaceutical Industry:
In the pharmaceutical sector, 3-Chloro-5-methylaniline is employed as a building block for the development of new drugs. Its specific functional groups enable targeted modifications that can lead to the creation of novel therapeutic agents with potential applications in treating various medical conditions.
Used in Research and Development:
3-Chloro-5-methylaniline also serves as a valuable research compound in academic and industrial laboratories. It is used to study the effects of structural modifications on chemical and biological properties, contributing to the advancement of scientific knowledge and the discovery of new applications in various fields.

Upstream product

• 618-61-1 3-methyl-5-nitro-aniline 
• 618-85-9 3,5-dinitrotoluene 
• 89-62-3 4-methyl-2-nitroaniline 
• 5465-33-8 2-chloro-4-methyl-6-nitroaniline 
• 16582-38-0 3-chloro-5-nitrotoluene 

Downstream Products

• 116632-43-0 1-chloro-3-iodo-5-methylbenzene 
• 887623-23-6 1,2-dideoxy-1-(3-chloro-5-methylphenyl)-β-D-ribofuranose 
• 74875-47-1 2-Chloro-N-(3-chloro-5-methyl-phenyl)-4-(3,5-dioxo-4,5-dihydro-3H-[1,2,4]triazin-2-yl)-benzenesulfonamide 
• 471909-97-4 3-chloro-5-methyl-phenyl isothiocyanate 
• 40233-54-3 3-chloro-5,N,N-trimethyl-aniline 
• 56978-43-9 N-(3-chloro-5-methylphenyl)acetamide 
• 99585-91-8 Chloressigsaeure-<5-chlor-3-methyl-anilid> 

Relevant articles and documents

Ligand Promoted meta-C-H Chlorination of Anilines and Phenols

Pd-catalyzed meta-C-H chlorination of anilines and phenols is developed using norbornene as the mediator. Heterocycles, including indole, thiophene, and indazole, are tolerated. The identification of a new pyridone-based ligand is crucial for the success of this meta-C-H chlorination reaction. Subsequent diverse transformations of the chlorinated products demonstrate the versatility of meta-C-H chlorination.

Fe2O3/NGr@C- and Co-Co3O4/NGr@C-catalysed hydrogenation of nitroarenes under mild conditions

An improved hydrogenation of nitroarenes using nano-structured iron- and cobalt-based catalysts is presented. Modifications of the heterogeneous catalysts by N-doped graphene-flakes are crucial for the success of selective reductions. The use of polar solvents and basic additives has a significant positive influence on the rate of reduction of nitroarenes. This allows performing non-noble metal-catalysed hydrogenations under very mild reaction conditions (e.g. 70 °C and 20 bar). On the basis of the obtained catalytic results a heterolytic mechanism for the hydrogenation process is postulated, too.

FACTOR IXA INHIBITORS

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Modulators Of HEC1 Activity And Methods Therefor

Compounds, compositions, and methods for modulation of Hec1/Nek2 interaction are provided. Especially preferred compounds disrupt Nek2/Hec1 binding and are therefore useful as chemotherapeutic agent for neoplastic diseases.

NEW SUBSTITUTED ARYLSULPHONYLGLYCINES, THE PREPARATION THEREOF AND THE USE THEREOF AS PHARMACEUTICAL COMPOSITIONS

The present invention relates to substituted arylsulphonylglycines of general formula (I) wherein R, X, Y and Z are defined as in claim 1, the tautomers, enantiomers, diastereomers, mixtures thereof and salts thereof, which have valuable pharmacological properties, particularly the suppression of the interaction of glycogen phosphorylase a with the GL subunit of glycogen-associated protein phosphatase 1 (PP1 ), and their use as pharmaceutical compositions.

Process for preparing 3-chloro-5-nitrotoluene

A preparation process of 3-chloro-5-nitrotoluene is provided in mild conditions. It is a process for preparing 3-chloro-5-nitrotoluene, which comprises reacting 2-methyl-4-nitroaniline with a chlorinating agent such as 5-butyl hypochlorite in a neutral co

Synthesis and structure - Activity relationships of chiral allosteric modifiers of hemoglobin

A series of allosteric effectors of hemoglobin, 2-(aryloxy)-2-alkanoic acids, was prepared to investigate the effect of the stereocenter on allosteric activity. The chiral analogues were based on the lead compound, RSR13 (3b), with different alkyl/alkanoic and cycloalkyl/cycloalkanoic groups positioned at the acidic chiral center. Of the 23 racemic molecules synthesized, 5 were selected for resolution based on structure - activity relationships. One chiral analogue, (-)-(1R,2R)-1-[4-[[(3,5-dimethylanilino)carbonyl]methyl]phenoxy]-2-methylcycl opentanecarboxylic acid (11), exhibited greater in vitro activity in hemoglobin solutions than its antipode, racemate, and RSR13. Compound (-)-(1R,2R)-11 was equipotent with RSR13 in whole blood, is a candidate for in vivo animal studies, and if efficacious and safe has a potential for use in humans. In general, it was found that chirality affects allosteric effector activity with measurable differences observed between enantiomers and the racemates.

Pyridazinedione compounds useful in treating neurological disorders

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The Kinetics of the Reactions of Picryl Chloride with Some Substituted Anilines. Part 5.

Arrhenius parameters have been measured for the reactions of picryl chloride with the following substituted anilines in acetonitrile: 3-amino- and 3-methyl-aniline, 3-amino-5-nitroaniline, 3-fluoro-5-methylsulphonylaniline, 3-X-5-methylanilines (X=NO2, OMe, CH3, F, Cl, Br, or I) and 3,5-X2-anilines (X = F, Cl, Br, or I).A total of 33 3,5-disubstituted anilines have now been examined for the additivity of substituent effects on the free energy of activation, and it has been shown that with the exception of 3-amino-5-nitroaniline this hypothesis reproduces experimental rate constants within a factor of 2.A rationalization is proposed for the deviations that occur in some cases when more stringent criteria of additivity are used.