30163-20-3

Basic information

• Product Name: 2-AMINO-3-(3-BROMO-PHENYL)-PROPIONIC ACID
• Synonyms: DL-3-Br-Phe-OH;DL-2-Amino-3-(3-bromo-phenyl)-propionic acid;Phenylalanine, 3-broMo-;DL-3-Br-Phe-OH 3-BroMo-DL-Phenylalanine;3-Bromophenyl-DL-alanine;H-DL-Phe(3-Br);2-AMINO-3-(3-BROMO-PHENYL)-PROPIONIC ACID;3-BROMO-DL-PHENYLALANINE
• CAS NO: 30163-20-3
• Molecular Formula: C₉H₁₀BrNO₂
• Molecular Weight: 244.09
• Product Categories: Phenylalanine analogs and other aromatic alpha amino acids;a-amino
• Mol File: 30163-20-3.mol

Chemical Properties

• Boiling Point: 368.4 °C at 760 mmHg
• Flash Point: 176.6 °C
• Appearance: /Solid
• Density: 1.588 g/cm³
• Vapor Pressure: 4.46E-06mmHg at 25°C
• Refractive Index: 1.608
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 2.16±0.10(Predicted)
• CAS DataBase Reference: 2-AMINO-3-(3-BROMO-PHENYL)-PROPIONIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-3-(3-BROMO-PHENYL)-PROPIONIC ACID(30163-20-3)
• EPA Substance Registry System: 2-AMINO-3-(3-BROMO-PHENYL)-PROPIONIC ACID(30163-20-3)

Safety Data

• Hazardous Substances Data: 30163-20-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Synthesis:
2-AMINO-3-(3-BROMO-PHENYL)-PROPIONIC ACID is used as a building block in the synthesis of pharmaceuticals for its potential biological activities. It contributes to the development of various biologically active compounds, enhancing their therapeutic effects and applications in medicine.
Used in Agrochemical Production:
In the agrochemical industry, 2-AMINO-3-(3-BROMO-PHENYL)-PROPIONIC ACID serves as a precursor in the production of agrochemicals. Its unique properties and potential biological activities make it a valuable component in the creation of effective and innovative agrochemical products.
Used in Chemical Compound Production:
2-AMINO-3-(3-BROMO-PHENYL)-PROPIONIC ACID is utilized as a precursor in the production of other chemical compounds. Its presence in the synthesis process allows for the development of new compounds with diverse applications across various industries, including chemical and industrial processes.

InChI:InChI=1/C9H10BrNO2/c10-7-3-1-2-6(4-7)5-8(11)9(12)13/h1-4,8H,5,11H2,(H,12,13)/t8-/m1/s1

Upstream product

• 14473-91-7 3-bromocinnamic acid 
• 823-78-9 meta-bromobenzyl bromide 
• 15017-44-4 diethyl (acetylamino)<(3-bromophenyl)methyl>propanedioate 

Downstream Products

• 331955-30-7 Z-DL-Phe(3Br) 
• 82278-95-3 rac-(3-(3-bromophenyl)-2-tert-butoxycarbonylamino)propionic acid 
• 868274-66-2 rac-(2-(3-bromophenyl)-1-formylethyl)carbamic acid tert-butyl ester 
• 868274-65-1 rac-(2-(3-bromophenyl)-1-hydroxymethylethyl)carbamic acid tert-butyl ester 

Relevant articles and documents

Bi-enzymatic Conversion of Cinnamic Acids to 2-Arylethylamines

The conversion of carboxylic acids, such as acrylic acids, to amines is a transformation that remains challenging in synthetic organic chemistry. Despite the ubiquity of similar moieties in natural metabolic pathways, biocatalytic routes seem to have been overlooked for this purpose. Herein we present the conception and optimisation of a two-enzyme system, allowing the synthesis of β-phenylethylamine derivatives from readily-available ring-substituted cinnamic acids. After characterisation of both parts of the reaction in a two-step approach, a set of conditions allowing the one-pot biotransformation was optimised. This combination of a reversible deaminating and irreversible decarboxylating enzyme, both specific for the amino acid intermediate in tandem, represents a general method by which new strategies for the conversion of carboxylic acids to amines could be designed.

Organocatalytic Enantioselective Addition of α-Aminoalkyl Radicals to Isoquinolines

With a dual organocatalytic system involving a chiral phosphoric acid and a dicyanopyrazine-derived chromophore (DPZ) photosensitizer and under the irradiation with visible light, an enantioselective Minisci-type addition of α-amino acid-derived redox-active esters (RAEs) to isoquinolines has been developed. A variety of prochiral α-aminoalkyl radicals generated from RAEs were successfully introduced on isoquinolines, providing a range of valuable α-isoquinoline-substituted chiral secondary amines in high yields with good to excellent enantioselectivities.

Hydroxyethylene sulfones as a new scaffold to address aspartic proteases: Design, synthesis, and structural characterization

Hydroxyethylene sulfones were developed as novel scaffolds against aspartyl proteases. A diastereoselective synthesis has been established to introduce the required side chain decoration with desired stereochemistry. Depending on the substitution of the h