307547-34-8

Basic information

• Product Name: [(8-Methyl-2-oxo-4-phenyl-2H-chromen-7-yl)oxy]-acetic acid
• Synonyms: [(8-Methyl-2-oxo-4-phenyl-2H-chromen-7-yl)oxy]-acetic acid;2-(2-keto-8-methyl-4-phenyl-chromen-7-yl)oxyacetic acid;2-(8-methyl-2-oxo-4-phenyl-chromen-7-yl)oxyacetic acid;2-(8-methyl-2-oxo-4-phenylchromen-7-yl)oxyacetic acid;2-(8-methyl-2-oxo-4-phenyl-chromen-7-yl)oxyethanoic acid;2-[(8-methyl-2-oxo-4-phenyl-7-chromenyl)oxy]acetic acid;Oprea1_661324;STOCK1N-21939
• CAS NO: 307547-34-8
• Molecular Formula: C18H14O5
• Molecular Weight: 310.30076
• Mol File: 307547-34-8.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: [(8-Methyl-2-oxo-4-phenyl-2H-chromen-7-yl)oxy]-acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: [(8-Methyl-2-oxo-4-phenyl-2H-chromen-7-yl)oxy]-acetic acid(307547-34-8)
• EPA Substance Registry System: [(8-Methyl-2-oxo-4-phenyl-2H-chromen-7-yl)oxy]-acetic acid(307547-34-8)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 307547-34-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
[(8-Methyl-2-oxo-4-phenyl-2H-chromen-7-yl)oxy]-acetic acid is used as a pharmaceutical compound for its potential biological activities. [(8-Methyl-2-oxo-4-phenyl-2H-chromen-7-yl)oxy]-acetic acid's anti-inflammatory, antioxidant, and anti-cancer properties make it a valuable asset in the development of new medications and therapies.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, [(8-Methyl-2-oxo-4-phenyl-2H-chromen-7-yl)oxy]-acetic acid is used as a research target to explore its potential therapeutic effects. Its unique chemical structure and promising biological activities encourage further investigation into its possible applications in the treatment of various diseases and conditions.
Used in Drug Development:
[(8-Methyl-2-oxo-4-phenyl-2H-chromen-7-yl)oxy]-acetic acid is utilized in drug development as a starting point for the creation of new pharmaceuticals. Its chemical structure can be modified and optimized to enhance its therapeutic properties, potentially leading to the discovery of more effective treatments for a range of health issues.

Upstream product

• 608-25-3 2-methylbenzene-1,3-diol 
• 307547-31-5 ethyl (8-methyl-4-phenyl-2H-1-benzopyran-2-on-7-yloxy)-acetate 
• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 65-85-0 benzoic acid 
• 93-89-0 benzoic acid ethyl ester 
• 21392-48-3 7-hydroxy-8-methyl-4-phenyl-chromen-2-one 

Relevant articles and documents

7-substituted-4-aryl coumarins compound, and preparation method and application thereof

The invention discloses a 7-substituted-4-aryl coumarins compound, and a preparation method and an application thereof and belongs to the technical field of antitumor drugs. The 7-substituted-4-aryl coumarins compound is acquired in the manner of modifying and remolding 4 and 7 loci of the coumarins. The structural formula is shown in the specification. A pharmacological experiment proves that such a compound has an excellent antitumor activity, can be used for preparing the antitumor drugs, is capable of supplying a new selection for the development and application of the antitumor drugs and further can be applied to the design and optimization of the antitumor drugs. The preparation method of the compound has the advantages of easily acquired raw materials, mild reaction condition, easily realized synthesis method, simple reaction process and operation, low-cost reagents and higher yield.

Rational Design, Synthesis and Evaluation of Coumarin Derivatives as Protein-protein Interaction Inhibitors

Herein we describe the design and synthesis of a new series of coumarin derivatives searching for novel HIV-1 integrase (IN) allosteric inhibitors. All new obtained compounds were tested in order to evaluate their ability to inhibit the interaction between the HIV-1 IN enzyme and the nuclear protein lens epithelium growth factor LEDGF/p75. A combined approach of docking and molecular dynamic simulations has been applied to clarify the activity of the new compounds. Specifically, the binding free energies by using the method of molecular mechanics-generalized Born surface area (MM-GBSA) was calculated, whereas hydrogen bond occupancies were monitored throughout simulations methods.