31458-33-0

Basic information

• Product Name: Pyrimidine, 5-methoxy- (6CI,7CI,8CI,9CI)
• Synonyms: Pyrimidine, 5-methoxy- (6CI,7CI,8CI,9CI);5-Methoxypyrimidine;PyriMidine, 5-Methoxy-
• CAS NO: 31458-33-0
• Molecular Formula: C₅H₆N₂O
• Molecular Weight: 110.12
• Product Categories: PYRIMIDINE;Aromatics;Bases & Related Reagents;Nucleotides;Heterocycle-Pyrimidine series
• Mol File: 31458-33-0.mol

Chemical Properties

• Melting Point: 46-47℃
• Boiling Point: 182℃
• Flash Point: 64℃
• Appearance: /
• Density: 1.102
• Vapor Pressure: 1.15mmHg at 25°C
• Refractive Index: 1.494
• Storage Temp.: 2-8°C
• Solubility: DMF
• PKA: 2.13±0.10(Predicted)
• CAS DataBase Reference: Pyrimidine, 5-methoxy- (6CI,7CI,8CI,9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrimidine, 5-methoxy- (6CI,7CI,8CI,9CI)(31458-33-0)
• EPA Substance Registry System: Pyrimidine, 5-methoxy- (6CI,7CI,8CI,9CI)(31458-33-0)

Safety Data

• Hazardous Substances Data: 31458-33-0(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
Pyrimidine, 5-methoxy(6CI,7CI,8CI,9CI) is used as an intermediate in the synthesis of various organic compounds. Its unique structure and functional groups make it a versatile building block for the development of pharmaceuticals, agrochemicals, and other specialty chemicals. The presence of the methoxy group allows for further chemical modifications, enabling the creation of a wide range of derivatives with diverse applications.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, Pyrimidine, 5-methoxy(6CI,7CI,8CI,9CI) is used as a key component in the development of drugs targeting various diseases. Its ability to form hydrogen bonds and participate in π-π interactions makes it a promising candidate for the design of novel therapeutic agents. Researchers can exploit its chemical properties to create molecules with specific biological activities, such as antimicrobial, antiviral, or anticancer properties.
Used in Agrochemical Industry:
Pyrimidine, 5-methoxy(6CI,7CI,8CI,9CI) also finds applications in the agrochemical industry, where it is used in the synthesis of pesticides, herbicides, and other crop protection agents. Its unique structure allows for the development of compounds with improved selectivity, efficacy, and reduced environmental impact. By incorporating this compound into the design of new agrochemicals, researchers can create more effective and sustainable solutions for modern agriculture.

InChI:InChI=1/C5H6N2O/c1-8-5-2-6-4-7-3-5/h2-4H,1H3

Upstream product

• 4595-59-9 5-bromopyrimidine 
• 124-41-4 sodium methylate 
• 51793-91-0 5-methoxy-3H-pyrimidine-4-thione 
• 695-87-4 5-methoxy-4(3H)-pyrimidinone 
• 6939-11-3 5-methoxy-2-thiouracil 
• 67-56-1 methanol 

Downstream Products

• 126327-68-2 (5-Methoxy-pyrimidin-4-yl)-phenyl-methanol 
• 19175-07-6 5-methoxy-4-methypyrimidine 
• 695-87-4 5-methoxy-4(3H)-pyrimidinone 
• 17325-26-7 Methyl imidazole-4-carboxylate 
• 36529-70-1 5-methoxypyrimidine N-oxide 
• 695-86-3 amino-4 methoxy-5 pyrimidine 
• 1383429-44-4 5-methoxy-α-[4-(trifluoromethoxy)phenyl]-4-pyrimidinemethanol 

Relevant articles and documents

A highly stable all-in-one photocatalyst for aryl etherification: The NiIIembedded covalent organic framework

The efficient conversion of aryl bromides to the corresponding aryl alkyl ethers by dual nickel/photocatalysis has seen great progress, but difficulties of recycling the photosensitizer or nickel complexes cause problems of sustainability. Here, we report the design of a novel, highly stable vinyl bridge 2D covalent organic framework (COF) containing Ni, which combines the role of photosensitizer and reactive site. The as-prepared sp2c-COFdpy-Ni acts as an efficient heterogeneous photocatalyst for C-O cross coupling. The sp2c-COFdpy-Ni can be completely recovered and used repeatedly without loss of activity, overcoming the limitations of the prior methods. Preliminary studies reveal that strong interlayer electron transfer may facilitate the generation of the proposed intermediate sp2c-COFdpy-NiI in a bimolecular and self-sustained manner. This all-in-one heterogeneous photocatalyst exhibits good compatibility of substrates and tolerance of functional groups. The successful attempt to expand the 2D COFs with this new catalyst into photocatalytic organic transformation opens an avenue for photoredox/transition metal mediated coupling reactions.

Electron-deficient heteroarenium salts: An organocatalytic tool for activation of hydrogen peroxide in oxidations

A series of monosubstituted pyrimidinium and pyrazinium triflates and 3,5-disubstituted pyridinium triflates were prepared and tested as simple catalysts of oxidations with hydrogen peroxide, using sulfoxidation as a model reaction. Their catalytic efficiency strongly depends on the type of substituent and is remarkable for derivatives with an electron-withdrawing group, showing reactivity comparable to that of flavinium salts which are the prominent organocatalysts for oxygenations. Because of their high stability and good accessibility, 4-(trifluoromethyl)pyrimidinium and 3,5-dinitropyridinium triflates are the catalysts of choice and were shown to catalyze oxidation of aliphatic and aromatic sulfides to sulfoxides, giving quantitative conversions, high preparative yields and excellent chemoselectivity. The high efficiency of electron-poor heteroarenium salts is rationalized by their ability to readily form adducts with nucleophiles, as documented by low pKR+ values (pKR+ red > -0.5 V). Hydrogen peroxide adducts formed in situ during catalytic oxidation act as substrate oxidizing agents. The Gibbs free energies of oxygen transfer from these heterocyclic hydroperoxides to thioanisole, obtained by calculations at the B3LYP/6-311++g(d,p) level, showed that they are much stronger oxidizing agents than alkyl hydroperoxides and in some cases are almost comparable to derivatives of flavin hydroperoxide acting as oxidizing agents in monooxygenases.

Mild and general palladium-catalyzed synthesis of methyl aryl ethers enabled by the use of a palladacycle precatalyst

A general method for the Pd-catalyzed coupling of methanol with (hetero)aryl halides is described. The reactions proceed under mild conditions with a wide range of aryl and heteroaryl halides to give methyl aryl ethers in high yield.

New compounds, pharmaceutical compositions and uses thereof

The invention relates to new compounds of the formula I to their use as medicaments, to methods for their therapeutic use and to pharmaceutical compositions containing them.

NOVEL INDOL CARBOXYLIC ACID BISPYRIDYL CARBOXAMIDE DERIVATIVES, PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, PREPARATION METHOD AND COMPOSITION CONTAINING THE SAME AS AN ACTIVE INGREDIENT

Disclosed herein are a new indole carboxylic acid bispyridyl carboxamide derivative, a preparation method thereof, and a composition for prevention or treatment of obesity, urinary disorders, and CNS disorders, containing the same as an active ingredient. Because the indole carboxylic acid bispyridyl carboxamide derivatives according to the present invention have high affinity for 5-HT2c receptors, act selectively on the 5-HT2c receptors, the derivatives rarely have adverse effects caused by other receptors. Because the derivatives effectively inhibit serotonin activity, they may be useful for treatment or prevention of obesity; urinary disorders such as urinary incontinence, premature ejaculation, erectile dysfunction, and prostatic hyperplasia; CNS disorders such as depression, anxiety, concern, panic disorder, epilepsy, obsessive-compulsive disorder, migraine, sleep disorder, withdrawal from drug abuse, Alzheimer's disease, and schizophrenia, associated with 5-HT2c receptors.

Novel indol carboxylic acid bispyridyl carboxamide derivatives as 5-HT2c receptor antagonists

Disclosed herein are a new indole carboxylic acid bispyridyl carboxamide derivative, a preparation method thereof, and a composition for prevention or treatment of obesity, urinary disorders, and CNS disorders, containing the same as an active ingredient. Because the indole carboxylic acid bispyridyl carboxamide derivatives according to the present invention have high affinity for 5-HT2c receptors, act selectively on the 5-HT2c receptors, the derivatives rarely have adverse effects caused by other receptors. Because the derivatives effectively inhibit serotonin activity, they may be useful for treatment or prevention of obesity; urinary disorders such as urinary incontinence, premature ejaculation, erectile dysfunction, and prostatic hyperplasia; CNS disorders such as depression, anxiety, concern, panic disorder, epilepsy, obsessive-compulsive disorder, migraine, sleep disorder, withdrawal from drug abuse, Alzheimer's disease, and schizophrenia, associated with 5-HT2c receptors.

NOVEL INDOL CARBOXYLIC ACID BISPYRIDYL CARBOXAMIDE DERIVATIVES, PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, PREPARATION METHOD AND COMPOSITION CONTAINING THE SAME AS AN ACTIVE INGREDIENT

Disclosed herein are a new indole carboxylic acid bispyridyl carboxamide derivative, a preparation method thereof, and a composition for prevention or treatment of obesity, urinary disorders, and CNS disorders, containing the same as an active ingredient. Because the indole carboxylic acid bispyridyl carboxamide derivatives according to the present invention have high affinity for 5-HT2c receptors, act selectively on the 5-HT2c receptors, the derivatives rarely have adverse effects caused by other receptors. Because the derivatives effectively inhibit serotonin activity, they may be useful for treatment or prevention of obesity; urinary disorders such as urinary incontinence, premature ejaculation, erectile dysfunction, and prostatic hyperplasia; CNS disorders such as depression, anxiety, concern, panic disorder, epilepsy, obsessive-compulsive disorder, migraine, sleep disorder, withdrawal from drug abuse, Alzheimer's disease, and schizophrenia, associated with 5-HT2c receptors.

Amino-pyridines as inhibitors of beta-secretase

The present invention provides an amino-pyridine compound of formula I The present invention also provides methods for the use thereof to inhibit β-secretase (BACE) and treat β-amyloid deposits and neurofibrillary tangles.

The Effect of Ring Nitrogen Atoms on the Homolytic Reactivity of Phenolic Compounds: Understanding the Radical-Scavenging Ability of 5-Pyrimidinols

Six substituted 5-pyrimidinols were synthesized, and the thermochemistry and kinetics of their reactions with free radicals were studied and compared to those of equivalently substituted phenols. To assess their potential as hydrogen-atom donors to free r

Novel chain-breaking antioxidants

Compounds, preferably 5-pyrimidinol and 3-pyridinol derivatives, that act as effective chain breaking antioxidants of both the lipid and water-soluble variety (analogous to the natural Vitamins E and C), many of which are more reactive toward peroxyl radicals than the most potent form of Vitamin E. These compounds may exhibit many chemopreventive effects associated with conditions in which free radical-mediated cellular damage or disruption is implicated and Vitamins E and C are shown to have protective effects. Additionally, these compounds should be excellent oxidation inhibitors as additives to fuels, lubricants, rubber, polymers, chemicals, solvents and foodstuffs.