320580-88-9Relevant articles and documents
Design, synthesis, and biological evaluation of novel phenol ether derivatives as non-covalent proteasome inhibitors
Yu, Jianjun,Xu, Lei,Hong, Duidui,Zhang, Xiaotuan,Liu, Jieyu,Li, Daqiang,Li, Jia,Zhou, Yubo,Liu, Tao
, p. 543 - 558 (2018/11/10)
A series of novel phenol ether derivatives were designed, synthesized, and evaluated as non-covalent proteasome inhibitors. Most compounds exhibited moderate to excellent proteasome inhibitory activity. In particular, compound 18x proved to be the most po
PYRIDOPYRAZINE COMPOUNDS AND THEIR USE IN THE TREATMENT, AMELIORATION OR PREVENTION OF INFLUENZA
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Paragraph 0152, (2016/01/30)
The present invention relates to a compound having the general formula (V), optionally in the form of a pharmaceutically acceptable salt, solvate, polymorph, codrug, cocrystal, prodrug, tautomer, racemate, enantiomer, or diastereomer or mixture thereof, w
Highly enantioselective synthesis of 2,3-dihydro-1 H-imidazo[2,1-a isoindol-5(9b H)-ones via catalytic asymmetric intramolecular cascade imidization-nucleophilic addition-lactamization
He, Yuwei,Cheng, Chuyu,Chen, Bin,Duan, Kun,Zhuang, Yue,Yuan, Bo,Zhang, Meisan,Zhou, Yougui,Zhou, Zihong,Su, Yu-Jun,Cao, Rihui,Qiu, Liqin
supporting information, p. 6366 - 6369 (2015/01/16)
Highly enantioselective catalytic asymmetric intramolecular cascade imidization-nucleophilic addition-lactamization of N1-alkylethane-1,2-diamine with methyl 2-formylbenzoate catalyzed by a chiral phosphoric acid represents the first efficient method for the preparation of medicinally interesting chiral 2,3-dihydro-1H-imidazo[2,1-a]isoindol-5(9bH)-ones with high yields and excellent enantioselectivities. This strategy has been shown to be quite general toward various methyl 2-formylbenzoates.
PIPERAZINYL ANTIVIRAL AGENTS
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Page/Page column 161, (2011/04/25)
Provided are compounds of Formula (I) and pharmaceutically acceptable salts thereof, their pharmaceutical compositions, their methods of preparation, and their use for treating viral infections mediated by a member of the Flaviviridae family of viruses such as hepatitis C virus (HCV).
OXINDOLE DERIVATIVES
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Page/Page column 77, (2008/06/13)
There is provided compounds of the formula wherein R6, V, W, X, Y, Q and n are as described. The compounds exhibit activity as anticancer agents.
Selective mono-BOC protection of diamines
Lee, Dae Woo,Ha, Hyun-Joon,Lee, Won Koo
, p. 737 - 742 (2007/10/03)
A facile route for mono-BOC protection of symmetrical and unsymmetrical diamines was developed by sequential additions of 1 mol of HCl and 1 mol of (BOC)2O followed by neutralization. Copyright Taylor & Francis Group, LLC.
Microwave-assisted synthesis and biological evaluation of novel uracil derivatives inhibiting human thymidine phosphorylase
Corelli, Federico,Botta, Maurizio,Lossani, Andrea,Pasquini, Serena,Spadari, Silvio,Focher, Federico
, p. 987 - 992 (2007/10/03)
New 5-chloro-6-substituted-uracil derivatives have been prepared by microwave assisted-synthesis and tested in vitro as thymidine phosphorylase inhibitors. One of these compounds showed potent inhibitory activity, with an IC50 value in the subm