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7-Bromo-2,3,4,5-tetrahydro-1H-benzo[b]azepine hydrochloride is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 321435-99-8 Structure
  • Basic information

    1. Product Name: 7-Bromo-2,3,4,5-tetrahydro-1H-benzo[b]azepine hydrochloride
    2. Synonyms: 7-Bromo-2,3,4,5-tetrahydro-1H-benzo[b]azepine hydrochloride;7-Bromo-2,3,4,5-tetrahydro-1H-benzo[b]azepine
    3. CAS NO:321435-99-8
    4. Molecular Formula: C10H12BrN
    5. Molecular Weight: 262.57392
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 321435-99-8.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 318.8±31.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.360±0.06 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. PKA: 4.40±0.20(Predicted)
    10. CAS DataBase Reference: 7-Bromo-2,3,4,5-tetrahydro-1H-benzo[b]azepine hydrochloride(CAS DataBase Reference)
    11. NIST Chemistry Reference: 7-Bromo-2,3,4,5-tetrahydro-1H-benzo[b]azepine hydrochloride(321435-99-8)
    12. EPA Substance Registry System: 7-Bromo-2,3,4,5-tetrahydro-1H-benzo[b]azepine hydrochloride(321435-99-8)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 321435-99-8(Hazardous Substances Data)

321435-99-8 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 321435-99-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,2,1,4,3 and 5 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 321435-99:
(8*3)+(7*2)+(6*1)+(5*4)+(4*3)+(3*5)+(2*9)+(1*9)=118
118 % 10 = 8
So 321435-99-8 is a valid CAS Registry Number.

321435-99-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 7-bromo-2,3,4,5-tetrahydro-1H-1-benzazepine,hydrochloride

1.2 Other means of identification

Product number -
Other names 7-Bromo-2,3,4,5-tetrahydro-1H-benzo[b]azepine hydrochloride

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:321435-99-8 SDS

321435-99-8Downstream Products

321435-99-8Relevant articles and documents

Tetrahydroquinoline-Capped Histone Deacetylase 6 Inhibitor SW-101 Ameliorates Pathological Phenotypes in a Charcot-Marie-Tooth Type 2A Mouse Model

Shen, Sida,Picci, Cristina,Ustinova, Kseniya,Benoy, Veronick,Kutil, Zsófia,Zhang, Guiping,Tavares, Maurício T.,Pavlí?ek, Ji?í,Zimprich, Chad A.,Robers, Matthew B.,Van Den Bosch, Ludo,Ba?inka, Cyril,Langley, Brett,Kozikowski, Alan P.

, p. 4810 - 4840 (2021/05/07)

Histone deacetylase 6 (HDAC6) is a promising therapeutic target for the treatment of neurodegenerative disorders. SW-100 (1a), a phenylhydroxamate-based HDAC6 inhibitor (HDAC6i) bearing a tetrahydroquinoline (THQ) capping group, is a highly potent and sel

FUSED 1,4-DIHYDRODIOXIN DERIVATIVES AS INHIBITORS OF HEAT SHOCK TRANSCRIPTION FACTOR 1

-

, (2015/04/22)

The present invention relates to compounds of formula I wherein A1, A2 R4 and Q are as defined herein. The compounds of the present invention are inhibitors of heat shock factor 1 (HSF1). In particular, the present invention relates to the use of these compounds as therapeutic agents for the treatment and/or prevention of proliferative diseases, such as cancer. The present invention also relates to processes for the preparation of these compounds, and to pharmaceutical compositions comprising them.

BIARYL-CONTAINING COMPOUNDS AS INVERSE AGONISTS OF ROR-GAMMA RECEPTORS

-

, (2014/01/18)

The present invention relates to biaryl-containing inverse agonists of ROR-gamma receptors. The invention also provides pharmaceutical compositions comprising these biaryl- containing inverse agonists, and methods of modulating ROR-gamma receptors using these inverse agonists. Also provided are methods of using biaryl-containing inverse agonists to treat ROR-gamma mediated diseases.

Ionic diamine rhodium complex catalyzed hydroaminomethylation of 2-allylanilines

Okuro, Kazumi,Alper, Howard

scheme or table, p. 4959 - 4961 (2011/01/12)

Ionic diamine rhodium complexes catalyze the hydroaminomethylation of 2-allylanilines. The reaction involves initial hydroformylation followed by reductive amination, which provides direct access to 1,2,3,4- tetrahydroquinolines and 2,3,4,5-1H-1-benzazepi

LXR modulators

-

Page/Page column 63, (2010/11/26)

A compound of formula I wherein A, X, q, R1, R2a, R2b, R2c, R3a, and R3b are defined herein.

Design, structure-activity relationship, and pharmacokinetic profile of pyrazole-based indoline factor Xa inhibitors

Varnes, Jeffrey G.,Wacker, Dean A.,Jacobson, Irina C.,Quan, Mimi L.,Ellis, Christopher D.,Rossi, Karen A.,He, Ming Y.,Luettgen, Joseph M.,Knabb, Robert M.,Bai, Steven,He, Kan,Lam, Patrick Y.S.,Wexler, Ruth R.

, p. 6481 - 6488 (2008/03/18)

A new series of pyrazole-based factor Xa inhibitors have been identified as part of our ongoing efforts to optimize previously reported clinical candidate razaxaban. Concern over the possible formation of primary aniline metabolites via amide hydrolysis led to the replacement of the primary amide linker between the pyrazole and phenyl moieties with secondary amides. This was accomplished by replacing the aniline with a variety of heterobicycles, of which indolines were the most potent. The indoline series demonstrated subnanomolar factor Xa binding Kis, modest to high selectivity versus other serine proteases, and good in vitro clotting activity. A small number of indoline fXa inhibitors were profiled in a dog pharmacokinetic model, one of which demonstrated pharmacokinetic parameters similar to that of clinical candidate razaxaban.

Nitrogen containing heterobicycles as factor Xa inhibitors

-

, (2008/06/13)

This invention relates generally to nitrogen containing heterobicycles of formulas A and B: which are inhibitors of trypsin-like serine protease enzymes, especially factor Xa, pharmaceutical compositions containing the same, and methods of using the same as anticoagulant agents for treatment and prevention of thromboembolic disorders.

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