324-41-4

Basic information

• Product Name: 2-Bromo-6-fluoronaphthalene
• Synonyms: 2-Bromo-6-fluoronaphthalene;2-fluoro-6-bromonaphthalene;5.2-Bromo-6-fluoro-naphthalene;2-Bromo-6-fluorophthalene;EOS-60456
• CAS NO: 324-41-4
• Molecular Formula: C₁₀H₆BrF
• Molecular Weight: 225.06
• EINECS: 1533716-785-6
• Product Categories: Benzene series;Fused Ring Systems;Halides;Fluorine series
• Mol File: 324-41-4.mol

Chemical Properties

• Melting Point: 64.0 to 68.0 °C
• Boiling Point: 140°C/9mmHg(lit.)
• Flash Point: 130.8 ºC
• Appearance: /
• Density: 1.563
• Vapor Pressure: 0.00451mmHg at 25°C
• Refractive Index: 1.638
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2-Bromo-6-fluoronaphthalene(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Bromo-6-fluoronaphthalene(324-41-4)
• EPA Substance Registry System: 2-Bromo-6-fluoronaphthalene(324-41-4)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 324-41-4(Hazardous Substances Data)

Usage

Chemical Properties

white solid

InChI:InChI=1/C10H6BrF/c11-9-3-1-8-6-10(12)4-2-7(8)5-9/h1-6H

Upstream product

• 7499-66-3 6-Bromonaphthalen-2-amine 
• 15231-91-1 6-bromo-naphthalen-2-ol 
• 5043-01-6 6-fluoro-2-naphthoic acid 
• 87700-58-1 6-fluoro-2-naphthoyl chloride 

Downstream Products

• 3799-80-2 2-(6-Fluor-naphthoyl-⁽²⁾)-benzoesaeure 
• 302959-28-0 (2RS,3SR)-1,2-dimethyl-3-[2-(6-fluoronaphthyl)-3-hydroxy]pyrrolidine hydrochloride 
• 5043-01-6 6-fluoro-2-naphthoic acid 
• 5043-00-5 methyl 6-fluoro-4-methyl-2-naphthoate 
• 38659-77-7 (C₆H₅)3SnCH₂C₁₀H₆F 
• 1332333-14-8 5-{[(3S)-1-(cyclopropylcarbonyl)-3-pyrrolidinyl]methyl}-4-[2-fluoro-4-(6-fluoro-2-naphthalenyl)phenyl]-2,4-dihydro-3H-1,2,4-triazol-3-one 
• 1426083-09-1 (2-{4-[4-(6-fluoro-naphthalen-2-yl)-1-methoxymethyl-5-pyridin-4-yl-1H-imidazol-2-yl]-phenoxy}-ethyl)-dimethyl-amine 
• 944351-48-8 (6-fluoronaphthalen-2-yl)methanol 
• 721968-77-0 6-fluoro-2-naphthaldehyde 

Relevant articles and documents

ARYL-PYRIDINE DERIVATIVES AS ALDOSTERONE SYNTHASE INHIBITORS

The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5 and n are defined herein. The invention also relates to a method for manufacturing compounds of the invention, and their therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

NIACIN RECEPTOR AGONISTS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT

The present invention relates to niacin receptor agonists of formula: (I); as well as pharmaceutically acceptable salts and solvates. The compounds are useful for treating dyslipidemias, and in particular, reducing serum LDL, VLDL and triglycerides, and raising HDL levels. Pharmaceutical compositions and methods of treatment are also included.

Synthesis and antinociceptive activity of pyrrolidinylnaphthalenes

In this paper the synthesis of the racemates (2R,3S/2S,3R)-1,2-dimethyl-3-[2-(6-substituted naphthyl)]-3-hydroxypyrrolidine 1b-d [(2R,3S/2S,3R)-1b-d] are reported. Compounds 1b-d were prepared by reaction of the racemic 1,2-dimethyl-3-pyrrolidone 2 with the lithiation product obtained from 2-bromo-6-substituted naphthalene 3b-d. Pharmacological properties of (2R,3S/2S,3R)-1a-d are also described. Analgesic activity was investigated by the hot plate test and binding affinities towards μ, δ and κ opioid receptors were evaluated. A preliminary evaluation of the in vivo side-effects was also accomplished using the rota-rod test. Interesting antinociceptive activity was shown by all compounds and in particular by 1d, which is the most active compound, since it is six-fold more potent than morphine and has lower side effects on the locomotory activity. Copyright (C) 2000 Elsevier Science Ltd.